Ethyl Chlorodifluoroacetate 二氟氯乙酸乙酯

CAS 383-62-0 MFCD00013662

化学结构图

383-62-0
SMILES: CCOC(=O)C(F)(F)Cl

化学属性

Mol. FormulaC4H5ClF2O2
Mol. Weight158.53
Boiling Point96-97.5 °C at 760 mmHg
Refractive index1.3550 to 1.3590
Density1.252
Flash Point28.9±15.1 °C
TSCAYes
Stability对湿度敏感
Appearance 无色有刺激性气味的发烟液体,相对密度1.675,熔点2℃,沸点105.3℃,溶有氯气或五氯化磷时呈红黄色。露于潮湿空气中即水解生成磷酸和氯化氢发生白烟,遇水和醇发生分解并放出大量热和盐酸气,对眼睛有刺激性、有腐蚀性。

别名和识别编码

Chemical NameEthyl Chlorodifluoroacetate
CAS Number383-62-0
Alfabeta NameETHYLCHLORODIFLUOROACETATE
MDL NumberMFCD00013662
PubChem Substance ID67843
EC Number206-850-0
Reaxys-RN1761413
Beilstein Registry Number1761413
Synonym Ethyl 2-chloro-2,2-difluoroacetate {LY} Ethyl 2-chloro-2,2-difluoroacetate {} {LY} Ethyl 2-chloro-2,2-difluoroacetate {} {} {LY} Ethyl 2-chloro-2,2-difluoroacetate {} {} {} {LY} Ethyl 2-chloro-2,2-difluoroacetate {} {} {} {} {LY} Ethyl 2-chloro-2,2-difluoroacetate {} {} {} {} {} {LY} Ethyl 2-chloro-2,2-difluoroacetate {} {} {} {} {} {} {LY} Ethyl 2-chloro-2,2-difluoroacetate {} {} {} {} {} {} {} {LY} Ethyl 2-chloro-2,2-difluoroacetate {} {} {} {} {} {} {} {} {LY} Ethyl 2-chloro-2,2-difluoroacetate {} {} {} {} {} {} {} {} {} {LY} Ethyl 2-chloro-2,2-difluoroacetate {} {} {} {} {} {} {} {} {} {} {LY} Ethyl 2-chloro-2,2-difluoroacetate {} {} {} {} {} {} {} {} {} {} {} {LY} Ethyl 2-chloro-2,2-difluoroacetate {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ethyl 2-chloro-2,2-difluoroacetate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ethyl 2-chloro-2,2-difluoroacetate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ethyl 2-chloro-2,2-difl
Chemical Name Translation二氟氯乙酸乙酯
LabNetwork Molecule IDLN00008650
InChIKeyGVCAWQUJCHZRCB-UHFFFAOYSA-N
InChIInChI=1S/C4H5ClF2O2/c1-2-9-3(8)4(5,6)7/h2H2,1H3
Canonical SMILESO=C(OCC)C(F)(Cl)F
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分类

  • {SNA} Alkyl Fluorinated Building Blocks, Building Blocks, C2 to C5, Carbonyl Compounds, Chemical Synthesis, Esters, Fluorinated Building Blocks, Organic Building Blocks, Organic Fluorinated Building Blocks, Other Fluorinated Organic Building Blocks
  • Alkyl Fluorinated Building Blocks, Building Blocks, C2 to C5, Carbonyl Compounds, Chemical Synthesis, Esters, Fluorinated Building Blocks, Organic Building Blocks, Organic Fluorinated Building Blocks, Other Fluorinated Organic Building Blocks

相关文献及参考

  • Wittig reactions with phosphorus ylides give enol ethers, which are useful precursors of various fluorinated derivatives: J. Org. Chem., 57, 3807 (1992); Org. Synth., 75, 153 (1997). See Ethyl­ trifluoroacetate, A11520, for reaction scheme.
  • Beilstein:2(4)497
  • For conversion to difluoromalonaldehyde derivatives, see: J. Chem. Soc., Chem. Commun., 540 (1992). These may be used in the synthesis of ɑ, ɑ -difluoro functionalized esters and amides.

安全信息

Warnings IRRITANT, FLAMMABLE
GHS Symbol
WGK Germany3
Hazard Codes 3 F,C
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P304+P340
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
UN Number 2924 UN2924
Risk Statements
  • R11 Highly flammable 非常易燃
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R34 Causes burns 会导致灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Storage condition 2-8°C {LY} 2-8°C Moisture Sensitive {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Packing GroupII
Hazard Class3/8

其他信息

  • Alfa Aesar:二氟氯乙酸乙酯,98% Ethyl chlorodifluoroacetate, 98%(383-62-0)
  • Sigma Aldrich:383-62-0(sigmaaldrich)
  • MOL 文件:383-62-0.mol
  • 用途一:广泛用于农药、医药、染料、磷酸酯及阻燃剂的生产
  • 下游产品:6-三氟甲基吡啶-3-醛
  • 图谱信息:二氟氯乙酸乙酯(383-62-0)红外图谱(IR1) 二氟氯乙酸乙酯(383-62-0)核磁图( 13 CNMR) 二氟氯乙酸乙酯(383-62-0)质谱(MS) 二氟氯乙酸乙酯(383-62-0)核磁图( 1 HNMR)
  • MSDS 信息:Chlorodifluoroacetic acid ethyl ester(383-62-0).msds
  • 敏感性:Moisture Sensitive
  • TCI Shanghai:二氟氯乙酸乙酯 Ethyl Chlorodifluoroacetate,>;97.0%(GC)(383-62-0)
  • 二氟氯乙酸乙酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C1458 二氟氯乙酸乙酯 Ethyl Chlorodifluoroacetate 500G 4430元 2014/06/02 C1458 二氟氯乙酸乙酯 Ethyl Chlorodifluoroacetate 25G 516元 2010/05/25 A14232 二氟氯乙酸乙酯, 98% Ethyl chlorodifluoroacetate, 98% 25g 976元
  • Hazard Note:Flammable

系列性分类


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