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• {SNA} Additional Standards, All alphabetical sorted,
• {SNA} Additional Standards,
• {SNA} Additional Standards,

产品应用

• Oral suntanning agent

相关文献及参考

• [2]. Huang DS, et al. Inhibitory effects of canthaxanthin on in vitro growth of murine tumor cells. Cancer Lett. 1992 Aug 31;65(3):209-13.
• [3]. Palozza P, et al. Canthaxanthin supplementation alters antioxidant enzymes and iron concentration in liver of Balb/c mice. J Nutr. 2000 May;130(5):1303-8.
• [4]. Chew BP, et al. A comparison of the anticancer activities of dietary beta-carotene, canthaxanthin and astaxanthin in mice in vivo. Anticancer Res. 1999 May-Jun;19(3A):1849-53.
• [5]. Grubbs CJ, et al. Effect of canthaxanthin on chemically induced mammary carcinogenesis. Oncology. 1991;48(3):239-45.
• Beil. 7 ,IV,2680
• Butler, M., et al.: Arch. Biochem. Biophys., 504, 154 (2010),
• Merck 14 ,1753
• Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.e

安全信息

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SCPHA4 Scientia Pharmaceutica.  (Oesterreichische
   Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria)
   V.1-    1930-  Volume(issue)/page/year: 47,39,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 86 mg/kg/15W-I
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - retinal changes (pigmentary
   depositions, retinitis, other)
REFERENCE :
   MJAUAJ Medical Journal of Australia.  (Australasian Medical Pub. Co. Ltd.,
   71-79 Arundel St., Glebe, N.S.W., Australia)  V.1-    1914-
   Volume(issue)/page/year: 143,622,1985

其他信息

• 上游原料:beta-胡萝卜素
• MOL 文件:514-78-3.mol
• 用途一:食用橙色色素，用作饮料、冰激凌、华夫等无辅料饼干k调味酱、番茄加工品、肉类加工品等。适量添加于白色蛋糕预制粉，可带杏子色调，烘烤后色素残留率可达96%。猪肉制的香肠中添加11mg/kg可得与牛肉制品相同的色调。
• 鉴别试验:溶解性不溶于水；不溶于乙醇；几不溶于植物油；溶于氯仿。按OT-42方法测定。 在环己烷溶液中，于468nm和472nm波长处有最大吸收峰。 类胡萝卜素阳性试验在丙酮溶液中的颜色，在相继添加5%亚硝酸钠溶液和1mol/L硫酸后消失。
• 使用限量:FAO/WHO(1984，mg/kg)：食用油脂按GMP；小虾、龙虾罐头及速冻品，肉汤、羹，30；果酱和果冻200；冷饮100。 FDA，§73.75(2000)：30mg/456g各类食品。 日本规定：在橙汁饮料中的添加量为1～5g/1000L；冰激凌中为10～30mg/kg；番茄汤料≥6mg/kg；番茄酱1mg/1.5g番茄固形物。
• 毒性:ADl 0～0.03(FAOWHO，2001)。 LD 50 ≥10g/kg(小鼠，经口)。
• 方法一:由β-胡萝卜素氧化而得。
• Sigma Aldrich:514-78-3(sigmaaldrich)
• 参考质量标准:FAO/WHO，1998 总色素含量(以斑蝥黄计) ≥96% 硫酸盐灰分(GT-5，试样2g) ≤0.1% 副色素 ≤5% 铅(GT-18-3) ≤2mg/kg
• 含量分析:精确称取试样约0.1g，然后按OT-15中方法一测定。 吸光系数E 1cm 1% =2200；最大吸收峰的波长约为470nm。W=9.1g；V 1 =V 2 =V 3 =100ml；v 4 = v 4 =5ml