3,4',5,7-Tetrahydroxyflavone 3,4',5,7-四羟基黄酮

CAS 520-18-3 MFCD00016938

化学结构图

520-18-3
SMILES: O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12

化学属性

Mol. FormulaC15H10O6
Mol. Weight286
Density1.688
Melting Point277
Solubilityethanol: 20 mg/mL
Appearance powder

别名和识别编码

Chemical Name3,4',5,7-Tetrahydroxyflavone
CAS Number520-18-3
Synonym 莰菲醇 5,7-四羟基黄酮 Trifolitin 4' 4,5,7三羟黄酮醇 {hazar 莰菲醇，3 猫眼草素I 山柰酚 山茶酚 KAEMPFEROL 3,5,7,4'-TETRAHYDROXYFLAVONE kaempherol Kampherol 崁非醇 山柰酚-3 Kaempherol kempferol pelargidenolon 山柰素 Kaempferol c.i.75640 Rhamnolutein 3,4',5,7-四羟基黄酮 3,4',5,7-TETRAHYDROXYFLAVONE 3,5,7-TRIHYDROXY-2-[4-HYDROXY-PHENYL]-4H-1-BENZOPYRAN-4-ONE {C { 3,4',5,7-Tetrahydroxyflavone; 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 3,4′,5,7-Tetrahydroxyflavone, 3,5,7-Trihydroxy-2-(4-hydroxypheny 山奈酚(素) C.I. 75640 3,4′,5,7-Tetrahydroxyflavone, 3
MDL NumberMFCD00016938
Beilstein Registry Number304401
EC Number208-287-6
Reaxys-RN304401
PubChem Substance ID5280863
Merck Number5274
Chemical Name Translation3,4',5,7-四羟基黄酮
Wiswesser Line NotationT66 BO EVJ CR DQ& DQ GQ IQ
InChIInChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
LabNetwork Molecule IDLN00008740
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分类

  • {SNA} Antioxidant and Free Radical Scavengers, Bioactive Small Molecules, Biochemicals and Reagents, Bioflavonoids, Cancer Metabolism, Cell Biology, Chemopreventive Agents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Fatty Acid Metabolism in Oncogenesis, Fatty Acid Synthase (FAS) Inhibitors, Flavonoids, Flavonols, and Flavanols, Inhibitors and Activators of Fatty Acid Metabolism, K, Nutrition Research, Phytochemicals by Chemical Classification, Phytoestrogens, R to Z, Topoisomerase I, 癌症研究
  • {SNA} Aesculus, Allium, Alphabetical, Ana

产品应用

  • 一种黄酮醇。能使佛波醇酯处理的小鼠成纤维细胞或v-H-ras-转化的 NIH 3T3细胞变形后的恢复。能显著诱导核DNA退化，同时伴随脂类的过氧化反应。抑制拓扑异构酶I催化的DNA再连接。

相关文献及参考

  • [2]. Luo H, et al. Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway. Food Chem. 2011 September 15; 128(2): 513-519.
  • [3]. An M, et al. Protective effects of Kaempferol against cardiac sinus node dysfunction via CaMKII deoxidization. Anat Cell Biol. 2015 Dec;48(4):235-43.
  • [4]. Shin D, et al. Dietary Compound Kaempferol Inhibits Airway Thickening Induced by Allergic Reaction in a Bovine Serum Albumin-Induced Model of Asthma. Int J Mol Sci. 2015 Dec 16;16(12):29980-95.
  • 2. Garg, B.S., et al., Spectrophotometric determination of antimony with 3,5,7,4′-tetrahydroxyflavone (kaempferol) Talanta 16 , 462-464, (1969)
  • Briggs, W., et al.: Plant Physiol., 125, 85 (2001),
  • Hertog, M., et al.: Nutr. Cancer, 20, 21 (1993),
  • Merck: 14,5274
  • Merck: 14,5274 Beilstein:18(3/4)3283
  • Peluso, M., et al.: Carcinogenesis, 21, 183 (2000),
  • [1]. Luo H, et al. Kaempferol nanoparticles

安全信息

GHS Symbol
Precautionary statements
  • P301+P310
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
Hazard statements
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
  • H301 Toxic if swallowed 吞食有毒
WGK Germany3
Signal word
RTECSLK9275200
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes T
Packing GroupIII
UN Number
Storage condition -20°C 储存温度 -20°C 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 25 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 113,45,1983

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 50 mg/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   33,3823,1984

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 100 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacter

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 20 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 246,205,1991

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 10 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 246,205,1991

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 20 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 246,205,1991

其他信息

  • 色指数:75640
  • Sigma Aldrich:520-18-3(sigmaaldrich)
  • MSDS 信息:3,4',5,7-Tetrahydroxyflavone(520-18-3).msds
  • 图谱信息:山奈酚(520-18-3)红外图谱(IR2) 山奈酚(520-18-3)核磁图( 1 HNMR) 山奈酚(520-18-3)质谱(MS) 山奈酚(520-18-3)红外图谱(IR1)
  • color:yellow
  • 存储注意事项:光敏感;空气敏感
  • F:8-10-23
  • MOL 文件:520-18-3.mol
  • TCI Shanghai:山奈酚 Kaempferol,>;97.0%(LC)(520-18-3)
  • 检测方法:HPLC,NMR
  • 山奈酚价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 K0018 山奈酚水合物 Kaempferol Hydrate 1G 8930元 2014/06/02 K0018 山奈酚水合物 Kaempferol Hydrate 100MG 1580元
  • 用途一:一种黄酮醇。能使佛波醇酯处理的小鼠成纤维细胞或v-H-ras-转化的 NIH 3T3细胞变形后的恢复。能显著诱导核DNA退化，同时伴随脂类的过氧化反应。抑制拓扑异构酶I催化的DNA再连接。

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. K - Bioactive Small Molecules
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Food & Beverage Standards - Chromatography
  5. Food Residue Analysis - Food & Beverage Standards
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Life Sciences Standards - Chromatography
  5. Phytopharma Standards - Life Sciences Standards
  6. Standards by Plant Genus - Phytopharma Standards
  7. Azadirachta - Standards by Plant Genus
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. R to Z - Enzyme Inhibitors by Enzyme
  7. Topoisomerase I - R to Z
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Flavonoids
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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