Daidzein 大豆素

CAS 486-66-8 MFCD00016954

化学结构图

486-66-8
SMILES: O=c1c(-c2ccc(O)cc2)coc2cc(O)ccc12

化学属性

Mol. FormulaC15H10O4
Mol. Weight254.24
Melting Point315-323°C
TSCANo
Density1.433
Solubility不溶
Appearance 苍黄色棱柱结晶或类白色结构性粉未;分解点315-323℃,溶于乙醇及乙醚。
Boiling Point512.8°C at 760 mmHg

别名和识别编码

Chemical NameDaidzein
CAS Number486-66-8
Alfabeta NameHYDROXYHYDROXYPHENYLCHROMENONE H73444()--------
MDL NumberMFCD00016954
Synonym Daidzein {LY} Daidzein {} {LY} Daidzein {} {} {LY} Daidzein {} {} {} {LY} Daidzein {} {} {} {} {LY} Daidzein {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {} {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {} {} {} {} {} {} {
Beilstein Registry Number18(5)4,89
EC Number207-635-4
Reaxys-RN231523
PubChem Substance ID5281708
Merck Number2801
Chemical Name Translation大豆素
LabNetwork Molecule IDLN00165964
InChIInChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H
Canonical SMILESO=C1C(C2=CC=C(O)C=C2)=COC3=CC(O)=CC=C13
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分类

  • {SNA} Apoptosis and Cell Cycle, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research, Cell Biology, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, Cell Signaling and Neuroscience, Chemopreventive Agents, D-DIF, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Flavonoids, Flavonols, and Flavanols, Nutrition Research, P to Q, Phytochemicals by Chemical Classification, Phytoestrogens, Protein kinase, tyrosine
  • {SNA} A - D, Alphabetical, Analytical Standards, Analytical/Chromatography, Chromatography,
  • {SNA} Apoptosis and Cell Cycle,
  • {SNA} Apoptosis and Cell Cycle,

产品应用

  • 一种植物雌激素,在阻碍荷尔蒙诱发的癌方面起主导作用,在 Swiss 3T3细胞在捕获细胞周期,可使Swiss 3T3细胞停在G1期。

相关文献及参考

  • [2]. Kim E, et al. Daidzein Augments Cholesterol Homeostasis via ApoE to Promote Functional Recovery in Chronic Stroke. J Neurosci. 2015 Nov 11;35(45):15113-26.
  • Am. J. Respir. Cell Mol. Biol., 7, 637 (1992),
  • Biochim. Biophys. Acta 1221, 29 (1994),
  • Merck: 14,2801
  • Merck: 14,2801 Beilstein:18(5)4,89
  • [1]. Sakamoto Y1, et al. The Dietary Isoflavone Daidzein Reduces Expression of Pro-Inflammatory Genes through PPARα/γ and JNK Pathways in Adipocyte and Macrophage Co-Cultures. PLoS One. 2016 Feb 22;11(2):e0149676.
  • [1]. Sakamoto Y1, et al. The Dietary Isoflavone Daidzein Reduces Expression of Pro-Inflammatory Genes through PPARα/γ and JNK Pathways in Adipocyte and Macrophage Co-Cultures. PLoS One. 2016 Feb 22;11(2):e0149676.
  • [2]. Kim E, et al. Daidzein Augments Cholesterol Homeostasis via ApoE to Promote Functional Recovery in Chronic Stroke. J Neurosci. 2015 Nov 11;35(45):15113-26.

安全信息

Warnings IRRITANT
GHS Symbol
RTECSDJ3100040
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
WGK Germany3
Signal word Warning {} {} {} {} {TCI}
Safety Statements
  • S24 Avoid contact with skin 避免皮肤接触;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S37 Wear suitable gloves 戴适当手套;
Risk Statements
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi
Storage condition 2-8°C, stored under nitrogen {LY} 2-8°C, stored under nitrogen {} {LY} 2-8°C, stored under nitrogen {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitro
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 13,51,1979

其他信息

  • 不溶于水,溶于DMSO:10 mg/mL。
  • Acros Organics:大豆苷元/大豆黄素 Daidzein, 98%(486-66-8)
  • 上游原料:乙醇 --> 盐酸 --> 乙醚
  • 用途三:一种植物雌激素,在阻碍荷尔蒙诱发的癌方面起主导作用,在 Swiss 3T3细胞在捕获细胞周期,可使Swiss 3T3细胞停在G1期。
  • 用途一:能促进畜禽和鱼虾等动物的生长,对冠心病有辅助治疗作用
  • Alfa Aesar:4',7-二羟基-异磺酮,97% 4',7-Dihydroxyisoflavone, 97%(486-66-8)
  • TCI Shanghai:4',7-二羟基异黄酮 Daidzein,>;95.0%(LC)(T)(486-66-8)
  • MSDS 信息:4',7-Dihydroxyisoflavone(486-66-8).msds
  • 用途二:血管扩张药。
  • MOL 文件:486-66-8.mol
  • 大豆素价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw020081 大豆黄酮 5g 360元 2011/04/16 D2668 大豆甙元 Daidzein 1G 520元 2010/06/21 328231000 大豆素 Daidzein 98% 100 MG 2709元
  • Sigma Aldrich:486-66-8(sigmaaldrich)
  • 检测方法:HPLC,NMR

系列性分类


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