Daidzein 大豆素

CAS 486-66-8 MFCD00016954

化学结构图

486-66-8
SMILES: O=c1c(-c2ccc(O)cc2)coc2cc(O)ccc12

化学属性

Mol. FormulaC15H10O4
Mol. Weight254.24
Melting Point315-323°C
TSCANo
Density1.433
Solubility不溶
Appearance 苍黄色棱柱结晶或类白色结构性粉未；分解点315-323℃，溶于乙醇及乙醚。
Boiling Point512.8°C at 760 mmHg

别名和识别编码

Chemical NameDaidzein
CAS Number486-66-8
Alfabeta NameHYDROXYHYDROXYPHENYLCHROMENONE H73444()--------
MDL NumberMFCD00016954
Synonym Daidzein {LY} Daidzein {} {LY} Daidzein {} {} {LY} Daidzein {} {} {} {LY} Daidzein {} {} {} {} {LY} Daidzein {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {} {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Daidzein {} {} {} {} {} {} {} {} {} {} {} {} {
Beilstein Registry Number18(5)4,89
EC Number207-635-4
Reaxys-RN231523
PubChem Substance ID5281708
Merck Number2801
Chemical Name Translation大豆素
LabNetwork Molecule IDLN00165964
InChIInChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H
Canonical SMILESO=C1C(C2=CC=C(O)C=C2)=COC3=CC(O)=CC=C13
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信息真实价格透明    资金保障    专业采购外包团队在线服务   
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分类

  • {SNA} Apoptosis and Cell Cycle, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research, Cell Biology, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, Cell Signaling and Neuroscience, Chemopreventive Agents, D-DIF, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Flavonoids, Flavonols, and Flavanols, Nutrition Research, P to Q, Phytochemicals by Chemical Classification, Phytoestrogens, Protein kinase, tyrosine
  • {SNA} A - D, Alphabetical, Analytical Standards, Analytical/Chromatography, Chromatography,
  • {SNA} Apoptosis and Cell Cycle,
  • {SNA} Apoptosis and Cell Cycle,

产品应用

  • 一种植物雌激素，在阻碍荷尔蒙诱发的癌方面起主导作用，在 Swiss 3T3细胞在捕获细胞周期，可使Swiss 3T3细胞停在G1期。

相关文献及参考

  • [2]. Kim E, et al. Daidzein Augments Cholesterol Homeostasis via ApoE to Promote Functional Recovery in Chronic Stroke. J Neurosci. 2015 Nov 11;35(45):15113-26.
  • Am. J. Respir. Cell Mol. Biol., 7, 637 (1992),
  • Biochim. Biophys. Acta 1221, 29 (1994),
  • Merck: 14,2801
  • Merck: 14,2801 Beilstein:18(5)4,89
  • [1]. Sakamoto Y1, et al. The Dietary Isoflavone Daidzein Reduces Expression of Pro-Inflammatory Genes through PPARα/γ and JNK Pathways in Adipocyte and Macrophage Co-Cultures. PLoS One. 2016 Feb 22;11(2):e0149676.
  • [1]. Sakamoto Y1, et al. The Dietary Isoflavone Daidzein Reduces Expression of Pro-Inflammatory Genes through PPARα/γ and JNK Pathways in Adipocyte and Macrophage Co-Cultures. PLoS One. 2016 Feb 22;11(2):e0149676.
  • [2]. Kim E, et al. Daidzein Augments Cholesterol Homeostasis via ApoE to Promote Functional Recovery in Chronic Stroke. J Neurosci. 2015 Nov 11;35(45):15113-26.

安全信息

Warnings IRRITANT
GHS Symbol
RTECSDJ3100040
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
WGK Germany3
Signal word Warning {} {} {} {} {TCI}
Safety Statements
  • S24 Avoid contact with skin 避免皮肤接触；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S37 Wear suitable gloves 戴适当手套；
Risk Statements
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi
Storage condition 2-8°C, stored under nitrogen {LY} 2-8°C, stored under nitrogen {} {LY} 2-8°C, stored under nitrogen {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitro 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 13,51,1979

其他信息

  • 不溶于水，溶于DMSO：10 mg/mL。
  • Acros Organics:大豆苷元/大豆黄素 Daidzein, 98%(486-66-8)
  • 上游原料:乙醇 --> 盐酸 --> 乙醚
  • 用途三:一种植物雌激素，在阻碍荷尔蒙诱发的癌方面起主导作用，在 Swiss 3T3细胞在捕获细胞周期，可使Swiss 3T3细胞停在G1期。
  • 用途一:能促进畜禽和鱼虾等动物的生长，对冠心病有辅助治疗作用
  • Alfa Aesar:4',7-二羟基-异磺酮,97% 4',7-Dihydroxyisoflavone, 97%(486-66-8)
  • TCI Shanghai:4'，7-二羟基异黄酮 Daidzein,>;95.0%(LC)(T)(486-66-8)
  • MSDS 信息:4',7-Dihydroxyisoflavone(486-66-8).msds
  • 用途二:血管扩张药。
  • MOL 文件:486-66-8.mol
  • 大豆素价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw020081 大豆黄酮 5g 360元 2011/04/16 D2668 大豆甙元 Daidzein 1G 520元 2010/06/21 328231000 大豆素 Daidzein 98% 100 MG 2709元
  • Sigma Aldrich:486-66-8(sigmaaldrich)
  • 检测方法:HPLC,NMR

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. D-DIF - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Chemical Classification - Nutrition Research
  4. Flavonoids, Flavonols, and Flavanols - Phytochemicals by Chemical Classification
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Phenols - Chemical Class
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Titration - Analytical Reagents
  4. Indicators - Titration
  5. Indicator Solutions - Indicators
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Food & Beverage Standards - Chromatography
  5. Food Residue Analysis - Food & Beverage Standards
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Life Sciences Standards - Chromatography
  5. Phytopharma Standards - Life Sciences Standards
  6. Standards by Plant Genus - Phytopharma Standards
  7. Glycine - Standards by Plant Genus
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. Cell Cycle Proteins and Antibodies - Apoptosis and Cell Cycle
  6. Cell Cycle Regulators - Cell Cycle Proteins and Antibodies
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Flavonoids
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Protein Kinases and Phosphatases
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Biochemicals Found in Plants
  4. Aromatic Compounds
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Apoptosis and Cell Cycle
  5. Cell Cycle
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Kinases and Phosphatases
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Nutrition Research
  4. Biochemicals Found in Plants
  5. Aromatic Compounds
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Proteins and Derivatives
  4. Proteins for Cell Biology
  5. Kinases and Phosphatases
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Apoptosis and Cell Cycle Proteins
  6. Apoptosis Inhibitors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Proteins for Cell Biology
  6. Immune System Proteins
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Protein kinase, DNA dependent
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Proteins and Derivatives
  4. Proteins for Cell Biology
  5. Apoptosis and Cell Cycle Proteins
  6. Apoptosis Inhibitors
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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