Ethoxyquin 乙氧基喹啉

CAS 91-53-2 MFCD00023883

化学结构图

91-53-2
SMILES: CCOc1ccc2c(c1)C(C)=CC(C)(C)N2

化学属性

Mol. FormulaC14H19NO
Mol. Weight217.31
Density1.03
Refractive index1.5720 to 1.5750
Melting Point<0 °C
Boiling Point333.1°C at 760 mmHg
Solubility<0.1 G/100 ML AT 20 ºC
Flash Point137.8°C
Appearance 纯品为浅褐色粘稠液体。 溶于苯、汽油、乙醚、乙醇、四氯化碳、丙酮、二氯乙烷,不溶于水。
Stability对光敏感

别名和识别编码

Chemical NameEthoxyquin
CAS Number91-53-2
Synonym Ethoxyquin {LY} Ethoxyquin {} {LY} Ethoxyquin {} {} {LY} Ethoxyquin {} {} {} {LY} Ethoxyquin {} {} {} {} {LY} Ethoxyquin {} {} {} {} {} {LY} Ethoxyquin {} {} {} {} {} {} {LY} Ethoxyquin {} {} {} {} {} {} {} {LY} Ethoxyquin {} {} {} {} {} {} {} {} {LY} Ethoxyquin {} {} {} {} {} {} {} {} {} {LY} Ethoxyquin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ethoxyquin {} {} {} {} {} {} {} {} {} {} {} {LY} Ethoxyquin {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ethoxyquin {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ethoxyquin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ethoxyquin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ethoxyquin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ethoxyquin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ethoxyquin {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00023883
PubChem Substance ID87569516
Beilstein Registry Number158223
EC Number202-075-7
Reaxys-RN158223
Merck Number3753
Chemical Name Translation乙氧基喹啉
Wiswesser Line NotationT66 BM CHJ C1 C1 E1 HO2
InChIInChI=1S/C14H19NO/c1-5-16-11-6-7-13-12(8-11)10(2)9-14(3,4)15-13/h6-9,15H,5H2,1-4H3
Canonical SMILESCC1=CC(C)(C)NC2=C1C=C(OCC)C=C2
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Alphabetic, Analytical Standards, Analytical/Chromatography, Chromatography, E, EQ - EZ, Environmental Standards, Fungicides, Pesticides, Pesticides & Metabolites, Quinolines
  • {SNA} Analytical Standards, E numbers (Food Additives), E300&#x2013;E399 (antioxidants, acidity regulators),
  • {SNA} Analytical Standards,
  • {SNA} Analytical Standards, E numbers (Food Additives), E300&#x2013;E399 (antioxidants, acidity regulators), E324, Food & Beverage Standards, Food and Cosmetic Component Standards, 分析/色谱
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, E numbers (Food Additives), E3

产品应用

  • 该品作为饲料、食品抗氧化剂应用较广,将该品喷雾在脱水饲料或收获前的饲料作物上,可防止脂肪、蛋白质饲料在贮存过程中变质。可用于维生素A和维生素E等药品的保存。该品也可用于苹果、梨子等水果的保鲜。也是污染性橡胶防老剂(抗氧剂AW),主要用于天然橡胶和合成橡胶,特别是丁苯橡胶。抗氧性和抗臭氧性优越,耐候性、耐热性和耐屈挠龟裂性亦佳。用于苹果和梨,能防治苹果虎皮病。

相关文献及参考

  • [2]. Zhu J, et al. Ethoxyquin prevents chemotherapy-induced neurotoxicity via Hsp90 modulation. Ann Neurol. 2013 Dec;74(6):893-904.
  • [3]. Zhu J, et al. Ethoxyquin provides neuroprotection against cisplatin-induced neurotoxicity. Sci Rep. 2016 Jun 28;6:28861.
  • ########
  • Merck: 14,3753
  • Merck: 14,3753 Beilstein: 21,V,3,95
  • [1]. Sadikot T, et al. Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors. Assay Drug Dev Technol. 2013 Oct;11(8):478-88.
  • [1]. Sadikot T, et al. Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors. Assay Drug Dev Technol. 2013 Oct;11(8):478-88.
  • [2]. Zhu J, et al. Ethoxyquin prevents chemotherapy-induced neurotoxicity via Hsp90 modulation. Ann Neurol. 2013 Dec;74(6):893-904.
  • [3]. Zhu J, et al. Ethoxyquin provides neuroprotection against cisplatin-induced neurotoxici

安全信息

Hazard statements
  • H302 Harmful if swallowed 吞食有害
RTECSVB8225000
Hazard Codes Xn
WGK Germany1
GHS Symbol
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Signal word Warning
UN Number 3082
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P301+P312+P330
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Safety Statements
  • S24 Avoid contact with skin 避免皮肤接触;
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
Packing GroupIII
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Hazard Class9
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 178 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - coma
REFERENCE :
   JAFCAU Journal of Agricultural and Food Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1953-  Volume(issue)/page/year: 7,203,1959

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1730 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CHABA8 Chemical Abstracts.  (Chemical Abstracts Service, Box 3012, Columbus,
   OH  43210) V.1-    1907-  Volume(issue)/page/year: 90,4601c,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RCTEA4 Rubber Chemistry and Technology.  (American Chemical Soc., Rubber
   Division, c/o Mrs. M.E. Bauer, Univ. of Akron, Akron, OH 44325)  V.1- 1928- 
   Volume(issue)/page/year: 45,627,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: A

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 200 ug/plate
REFERENCE :
   PCBRD2 Progress in Clinical and Biological Research.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1975- Volume(issue)/page/year:
   141,407,1984

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 13 gm-kg/4W (Continuous)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   99,37,1989

其他信息

  • 含量分析:精确称取试样约200mg,移人盛有50ml冰醋酸的-150ml烧杯中,立即用0.1mol/L高氯酸的冰醋酸溶
  • 参考质量标准三:GB 8849-1988 含量(以C14H19NO计)/% ≥95.0 对氨基苯乙醚,% ≤1.0 重金属(以Pb计)/% ≤0.001 砷(以As计)/% ≤0.0003
  • 毒性分级:中毒
  • 乙氧基喹啉价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 E0237 6-乙氧基-2,2,4-三甲基-1,2-二氢喹啉[橡胶抗氧化剂] 6-Ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline [Antioxidant for rubber] 500G 1320元 2014/06/02 E0237 6-乙氧基-2,2,4-三
  • 用途八:该品作为饲料、食品抗氧化剂应用较广,将该品喷雾在脱水饲料或收获前的饲料作物上,可防止脂肪、
  • 图谱信息:乙氧基喹啉(91-53-2)质谱(MS) 乙氧基喹啉(91-53-2)红外图谱(IR1) 乙氧基喹啉(91-53-2)核磁图( 13 CNMR) 乙氧基喹啉(91-53-2)核磁图( 1 HNMR)
  • 使用限量:GB 2760-96:苹果保鲜,以GMP为限,残留量@≤lmg/k
  • 溶于苯、汽油、醚、醇、四氯化碳、丙酮、二氯乙烷,不溶于水。性质较稳定。
  • 方法二:一般由对氨基苯乙醚与丙酮在催化剂作用下缩合而得。将对氨基苯乙醚、催化剂(对甲苯磺酸或碘),在155~165℃和搅拌下通入丙酮蒸气进行缩合。反应生成的水和未反应的丙酮,经冷凝后入丙酮回收器以回收丙酮。反应结束后,蒸馏得到成品。每吨产品消耗对氨基苯乙醚1000kg、丙酮800kg、苯磺酸100kg。 也可用1%I2作催化剂,在120~130℃下缩合
  • 急性毒性:口服- 大鼠 LD50 800 毫克/ 公斤; 口服- 小鼠 LD50: 1584 毫克/公斤
  • {Chemicalb
  • Sigma A
  • 所属类别三:饲料添加剂: 饲料贮存添加剂
  • 用途七:该品作为饲料、食品抗氧化剂应用较广,将该品喷雾在脱水饲料或收获前的饲料作物上,可防止脂肪、蛋白质饲料在贮存过程中变质。可用于维生素A和维生素E等药品的保存。防止罐装肉食品、动物性饲料中有机过氧化物的形杨。改善维生素E在雏鸡体内的摄取情况,使用其维持在正常水平。改善胴体质量及增加动物体重。该品也可用于苹果、梨子等水果的保鲜;据报道,乙氧喹是预防绵羊采食橡胶草中毒的有
  • 方法三:一般由对氨基苯乙醚与丙酮在催化剂作用下缩合而得: 可用苯磺酸为催化剂,将丙酮蒸汽通入对氨基苯乙醚,于155-165℃下进行缩合。反应生成的水和未反应的丙酮经冷凝后进入丙酮回收器以回收丙酮。反应结束后,蒸馏得成品。每吨产品消耗对氨基苯乙醚1000kg、丙酮800kg、苯磺酸100kg。 也可用1%I2作催化剂,在120-130℃下缩合。
  • 用途三:用作饲料添加剂
  • 鉴别试验:试样lmg在乙腈10ml中的溶液,在短波长的紫外线下观察时,应呈强荧光。
  • 用途四:乙氧基喹啉一般以喷雾法喷布于饲料表面,可有效防止饲料中油脂酸败和蛋白质氧化,且能防止维生素变质,具有抗氧化作用。饲料中用量100-150g/kg。
  • 毒性:GRAS(FDA,§172.140,2000)。 LD 50 800mg/kg(大鼠,经口)。
  • 方法
  • 所属类别一:食品添加剂: 抗氧化剂
  • MOL 文件:91-53-2.mol
  • 类别:有毒物质
  • 用途六:乙氧基喹啉具有
  • TCI Shanghai:6-乙氧基-2,2,4-三甲基-1,2-二氢喹啉[橡胶抗氧化剂] 6-Ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline [Antioxidant for rubber],>;90.0%(GC)(91-53-2)

系列性分类


相关产品推荐