Nitarsone 4-硝基苯胂酸

CAS 98-72-6 MFCD00024575

化学结构图

98-72-6
SMILES: O=[N+]([O-])c1ccc([As](=O)(O)O)cc1

化学属性

Mol. FormulaC6H6AsNO5
Mol. Weight247
Solubility微溶于水、乙醇，溶于热水、热乙醇。

别名和识别编码

Chemical NameNitarsone
CAS Number98-72-6
Synonym histostat50 {uni_hamburg} Arsonic acid, 4-nitrophenyl p-nitro-benzenearsonicaci 4-nitrobenzenearsonicacid 硝苯胂酸 histostat ######## 4-硝基苯胂酸 Hep-A-stat 4-Nitrobenzenearsonic acid arsonicacid,4-nitrophenyl (4-Nitrophenyl)arsonic acid p-Nitrobenzenearsonic acid Nitarsone P-NITROBENZENEARSONIC ACID 4-nitrophenylarsonic acid nitarson Nitarson 4-Nitrophenyl arsonic acid Histostat 50 hep-a-stat Arsonic acid, (4-nitrophenyl)- nitarsone (INN) 4-NBA RAS-26 Hep-a-Stat Histostat-50 ep-a-stat NITARSONE 4-Nitrophenylarsonic acid NSC-5085 (p-Nitrophenyl)arsonic acid BENZENEARSONICACID,PARA-NITRO- ras-26 p-Nitrophenylarsonic acid 4-Nitrophenylarsonsäure 对硝基苯胂酸 P-NITROPHENYLARSONIC ACID Benzenearsonic acid, p-nitro- p-Nitrophenylarsonic acid Histostat
MDL NumberMFCD00024575
EC Number202-695-8
Chemical Name Translation4-硝基苯胂酸
Merck Number13,6594
Wiswesser Line NotationWNR D-AS-QQO
Beilstein Registry Number2939908
LabNetwork Molecule IDLN00240746
PubChem Substance ID66826
InChIInChI=1S/C6H6AsNO5/c9-7(10,11)5-1-3-6(4-2-5)8(12)13/h1-4H,(H2,9,10,11)
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分类

  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 1fragment
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Life Sciences Standards, N, NA - NI, Pharmacology Standards

产品应用

  • Nitarsone is used as an antihistomonad.

相关文献及参考

  • Jackson, B., et al.: Environ. Sci. Technol., 2001, 35, 4868 (2001),
  • Garbarino, J., et al.: Environ. Sci. Technol., 37, 1509 (2003),
  • Liu, J., et al.: J. Environ. Monit., 10, 975 (2008),
  • Short: III/20b Title: Nuclear Quadrupole Resonance Spectroscopy Data: Nuclei Cl ... Rb Author: Chihara, H.; Nakamura, N. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: III/20b Year: 1988 Keyword: NQR ISBN: 3-540-18483-X ISBN: 978-3-540-18483-6 Internet Resource: DOI:10.1007/b86664 RefComment: IX,717 pages. Hardcover Abstract: Nuclear Quadrupole Resonance Spectroscopy has become a standard method for structural research in molecular and solid state physics as well as for different branches of chemistry. The volumes cover data for more than 8,000 substances in the solid state. Data for free molecules have been published in volumes II/14 and II/15 of the New Series. The tables are arranged according to the atomic number of the elements.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

RTECSCY6125000
GHS Symbol
Precautionary statements
  • P301+P310
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
Hazard statements
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H301+H331
WGK Germany3
Signal word Danger
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S20/21 When using do not eat, drink or smoke 使用时，不得进食，饮水或吸烟；
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Hazard Codes T,N
Risk Statements
  • R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
  • R50/53
UN Number UN3465 6.1/PG 3
Warnings 危化品目录(2015) 危险化学品 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCNSA6 National Academy of Sciences, National Research Council,
   Chemical-Biological Coordination Center, Review.  (Washington, DC)
   Volume(issue)/page/year: 5,13,1953

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#01192

其他信息

  • 方法一:由对硝基苯胺重氮化、胂化而得。将对硝基苯胺加入盐酸中，搅拌2h，投入冰块降温至-5℃，在15min内加入亚硝酸钠溶液，搅拌约1h，得重氮盐溶液。将三氧化二砷和碳酸钠溶解于水，冷至25℃以下，加入硫酸铜溶液，再将上述重氮盐溶液加入，反应温度控制在25℃以下，即得生成对硝基苯胂酸。
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • 毒性分级:高毒
  • 可燃性危险特性:受热分解有毒的氧化氮和砷化物气体
  • MOL 文件:98-72-6.mol
  • Sigma Aldrich:98-72-6(sigmaaldrich)
  • MSDS 信息:4-硝基苯胂酸(98-72-6).msds
  • 下游产品:4-氨基苯胂酸 --> 卡巴胂
  • 职业标准:TWA 0.5 毫克 (砷)/立方米; STEL 0.6 毫克 (砷)/立方米
  • 上游原料:N-甲基对硝基苯胺 --> 砷烷
  • 外观性质:淡黄色结晶。
  • 用途一:用作医药中间体，也是一种分析试剂。
  • 灭火剂:二氧化碳、砂土、水
  • 急性毒性:口服-大鼠 LDL0: 100 毫克/公斤
  • 类别:有毒物品

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Life Sciences Standards - Chromatography
  5. Pharmacology Standards - Life Sciences Standards

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