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分类

• {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards C - D, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
• {SA} Alphabetic, Analytical Standards, Analytical/Chromatography, Antibiotics, Chemical Structure, Chromatography, Clinical Standards, D, DA - DH, Others
• {SNA} Analytical Standards,
• {SNA} Analytical Standa
• {SNA} Bioactive Small Molecules,
• {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Antibiotics, Chemical Structure, Chromatography, Clinical Standards, D,

产品应用

• Protected Dexamethasone, a glucocorticoid anti-inflammatory agent.

相关文献及参考

• [2]. Adcock IM, et al. Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement. Br J Pharmacol. 1999 Jun;127(4):1003-11
• [3]. Rocksén D, et al. Differential anti-inflammatory and anti-oxidative effects of Dexamethasone and N-acetylcysteine in endotoxin-induced lung inflammation. Clin Exp Immunol. 2000 Nov;122(2):249-56
• [4]. Roussel D, et al. Dexamethasone treatment specifically increases the basal proton conductance of rat liver mitochondria. FEBS Lett. 2003 Apr 24;541(1-3):75-9.
• [5]. Li X, et al. Mucoadhesive dexamethasone acetate-polymyxin B sulfate cationic ocular nanoemulsion--novel combinatorial formulation concept. Pharmazie. 2016 Jun;71(6):327-33.
• Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),
• Liu, Y., et al.: Anal. Bioanal. Chem., 395, 591 (2009),
• Merck: 14,2943
• Merck: 14,2943 Beilstein: 8,IV,

安全信息

{h

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1200 ug/kg
SEX/DURATION            : female 12-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 23,15,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 mg/kg
SEX/DURATION            : female 15-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - abortion
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 22,735,1971

TYPE OF TEST            : TDLo - Lowest p

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Ocular
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 6 mg/kg
SEX/DURATION            : female 10-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 16,175,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED

其他信息

• 下游产品:9Α-氟-16Α-甲基孕甾-1,4-二烯-11Β,17Α,21-三醇-3,20-二酮-21-磷酸酯哌嗪盐
• 醋酸地塞米松价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 D3628 21-乙酸地塞米松 Dexamethasone 21-Acetate 5G 1420元 2014/06/02 D3628 21-乙酸地塞米松 Dexamethasone 21-Acetate 1G 370元
• 上游原料:氢氟酸 --> 乙二醇 --> 溴甲烷 --> 孕酮
• TCI Shanghai:乙酸地塞米松 Dexamethasone 21-Acetate,>;98.0%(LC)(1177-87-3)
• 方法一:可用16α,17α-环氧孕甾-4-烯-3,11,20-三酮（即16α,17α-环氧-11-酮基黄体酮）经（3-位、20-位酮基）缩酮化、（11-位酮基）还原、消除[9（11）-位脱水形成双键]、（环氧基与甲基溴化镁）加成并水解（形成17α-羟基，16β-甲基）、水解（脱除乙二醇）得17α-羟基-16β-甲基孕甾-4,9（11）-二烯-3,20-二酮，然后经（4、5-位）脱氢（形成双键）、（21-位）碘化、（21-位碘经乙酰氧基）置换，[9（11）-位双键与次溴酸]加成、[9（11）-位]环氧化、9（11）位氟化氢加成后制得该品。
• 用途一:倍他米松、地塞米松磷酸钠的中间体。用于抗炎和抗过敏，适用于类风湿性关节炎和其他胶原性疾病等。
• MOL 文件:1177-87-3.mol
• Sigma Aldrich:1177-87-3(sigmaaldrich)
• 图谱信息:16alpha-甲基-11beta,17alpha,21-三羟基-9alpha-氟孕甾-1,4-二烯-3,20-二酮-21-醋酸酯(1177-87-3)核磁图( 13 CNMR) 16alpha-甲基-11beta,17alpha,21-三羟基-9alpha-氟孕甾-1,4-二烯-3,20-二酮-21-醋酸酯(1177-87-3)质谱(MS) 16alpha-甲基-11beta,17alpha,21-三羟基-9alpha-氟孕甾-1,4-二烯-3,20-二酮-21-醋酸酯(1177-87-3)核磁图( 1 HNMR) 16alpha-甲基-11beta,17alpha,21-三羟基-9alpha-氟孕甾-1,4-二烯-3,20-二酮-21-醋酸酯(1177-87-3)红外图谱(IR1) 16alpha-甲基-11beta,17alpha,21-三羟基-9alpha-氟孕甾-1,4-二烯-3,20-二酮-21-醋酸酯(1177-87-3)红外图谱(IR2)