(-)-Epinephrine (+)-bitartrate salt 酒石酸肾上腺素
CAS 51-42-3 MFCD00035077
化学结构图
SMILES: CNCC(O)c1ccc(O)c(O)c1.O=C(O)C(O)C(O)C(=O)O
化学属性
| Mol. Formula | C9H13NO3· C4H6O6 |
|---|---|
| Mol. Weight | 333.29 |
| Melting Point | ~155 °C (dec.) |
| Solubility | DMSO 67 mg/mL Water 67 mg/mL Ethanol <1 mg/mL |
| Appearance | solid |
| Refractive index | -16.5 ° (C=2, H2O) |
别名和识别编码
| Chemical Name | (-)-Epinephrine (+)-bitartrate salt |
|---|---|
| Synonym | L-1-(3,4-DIHYDROXYPHENYL)-2-METHYLAMINOETHANOL BITARTRATE
Adrenaline bitartrate
L-Adrenaline (+)-bitartrate salt, L-3,4-Dihydroxy-alpha-(methylaminomethyl)benzyl alcohol D-hydrogen bitartrate salt
(-)-Adrenaline bitartrate
(-)-EPINEPHRINE (+)BITARTRATE SALT
酒石酸肾上腺素
(-)-EPINEPHRINE-(+)-HYDROGEN TARTRATE
L-(-)-EPINEPHRI
|
| MDL Number | MFCD00035077 |
| CAS Number | 51-42-3 |
| PubChem Substance ID | 5815 |
| EC Number | 200-097-1 |
| Chemical Name Translation | 酒石酸肾上腺素 |
| Merck Number | 13,3650 |
| Wiswesser Line Notation | QR BQ DYQ1M1 &QVYQYQVQ -L -D |
| LabNetwork Molecule ID | LN00239162 |
| InChI | InChI=1S/C9H13NO3.C4H6O6/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;5-1(3(7)8)2(6)4(9)10/h2-4,9-13H,5H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t9-;1-,2-/m01/s1 |
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分类
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards A - B, Pharmaceutical Standards,
- {SNA} Adrenergics, Adrenergics - Agonists, Agonists, Bioactive Small Molecule Alphabetical Index, Biochemicals and Reagents, E, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Proteins and Derivatives, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards,
- {SNA}
产品应用
- An α,β-adrenergic receptor agonist.
安全信息
GHS Symbol
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P301+P310
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H319 Causes serious eye irritation 严重刺激眼睛
- H300 Fatal if swallowed 吞食致命
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R28 Very toxic if swallowed 吞咽极毒
{hazard_TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURAT
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1780 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,269,1944
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 7800 ug/kg TOXIC EFFECTS : Cardiac - cardiomyopathy including infarction REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 31,43,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 8300 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,122,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 31,49,1972
TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Cells - not otherwise specified DOSE/DURATION : 1 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,3514,1983
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE : 2400 ug/kg SEX/DURATION : male 2 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 22,375,1970
其他信息
- 毒性分级:剧毒
- Epinephrine Bitartrate 是一种α和β-肾上腺素能受体激动剂。
- Sigma Aldrich:51-42-3(sigmaaldrich)
- (-)-肾上腺素 (+)-酒石酸氢盐
- MOL 文件:51-42-3.mol
- color:white
- 储运特性:库房通风低温干燥; 与食品原料分开存放
- 用途一:主要用于过敏性休克、支气管哮喘及心搏骤停的抢救
- 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
- 急性毒性:口服-小鼠 LD50: 4 毫克/公斤；腹腔-小鼠 LD50：0.78 毫克/公斤
- TCI Shanghai:酒石酸-L-肾上腺素 L-Adrenaline Bitartrate,>;98.0%(LC)(T)(51-42-3)
- 可燃性危险特性:可燃; 燃烧释放有毒氮氧化物烟雾
- F:8-10-23
- 图谱信息:酒石酸肾上腺素(51-42-3)红外图谱(IR1) 酒石酸肾上腺素(51-42-3)质谱(MS) 酒石酸肾上腺素(51-42-3)核磁图( 1 HNMR) 酒石酸肾上腺素(51-42-3)红外图谱(IR2)
- 类别:有毒物品
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