Alverine Citrate N-乙基-3-苯基-N-(3-苯基丙基)丙烷-1-胺柠檬酸盐
CAS 5560-59-8 MFCD00035086
化学结构图
SMILES: CCN(CCCc1ccccc1)CCCc1ccccc1.O=C(O)CC(O)(CC(=O)O)C(=O)O
化学属性
| Mol. Formula | C26H35NO7 |
|---|---|
| Mol. Weight | 474 |
| Solubility | DMSO mg/mL Water mg/mL Ethanol mg/mL |
别名和识别编码
| Chemical Name | Alverine Citrate |
|---|---|
| CAS Number | 5560-59-8 |
| Synonym | Alverine base or citrate BIS-GAMMA-PHENYLPROPYLETHYLAMINE DIHYDROGEN CITRATE Benzenepropanamine, N-ethyl-N-(3-phenylpropyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) N-ETHYL-3,3-DIPHENYLDIPROPYLAMINE CITRATE SALT N-Ethyl-3,3'-diphenyldipropylamine citrate N-Ethyl-3,3-diphenyldipropylamine N-Ethyl-3,3′-diphenyldipropylamine N-Ethyl-N-(3-phenylpropyl)benzenepropanamine 2-Hydroxy-1,2,3- N-乙基-3,3'-二苯二丙胺柠檬酸盐 N-乙基-3,3′-二苯二丙胺 N-乙基-3,3′-二苯二丙胺 NSC 35459 NSC 35459 Profenil citrate alverine dihydrogen citrate 枸橼酸阿尔维林 阿尔维林 柠檬酸盐 阿尔维林 柠檬酸盐;N-乙基-3,3′-二苯二丙胺; NSC 35459;枸橼酸阿尔维林; N-乙基-3,3'-二苯二丙胺柠檬酸盐 |
| MDL Number | MFCD00035086 |
| PubChem Substance ID | 57653816 |
| EC Number | 226-929-3 |
| Chemical Name Translation | N-乙基-3-苯基-N-(3-苯基丙基)丙烷-1-胺柠檬酸盐 |
| LabNetwork Molecule ID | LN00201459 |
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分类
- {SNA} Analytical Standards, EP Standards, EP Standards A - B, Pharmacopeia Metrological Institutes Standards, 分析/色谱
- {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards A - B, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
- {SNA} Analytical Standards, Analytical/C
产品应用
- Used for studies of pharmacological activity including:
- Synergism with fluconazole against Saccharomyces cerevisiae and Candida albicans1;
- Efficacy of combination with simeticone on abdominal pain associated with irritable bowel syndrome;
- Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis;
- Drug effects viewed from a signal transduction network perspective;
- Enhanced cytotoxic effect of proteasome inhibitor MG132; Mechanism of action on phasic smooth muscles.
相关文献及参考
- [2]. Hayase, M., et al., Evolving mechanisms of action of alverine citrate on phasic smooth muscles. Br J Pharmacol, 2007. 152(8): p. 1228-38.
- Salim, E.F., et al.: J. Pharm. Sci., et al.: 56, 1162 (1967),
- Stuhner, et al.: Arch. Pharm., 287, 139 (1954),
- Tudor, G.J., et al.: Br. J. Clin. Pract., 40, 276 (1985),
- [1]. Coelho, A.M., et al., Rectal antinociceptive properties of alverine citrate are linked to antagonism at the 5-HT1A receptor subtype. J Pharm Pharmacol, 2001. 53(10): p. 1419-26.
- [1]. Coelho, A.M., et al., Rectal antinociceptive properties of alverine citrate are linked to antagonism at the 5-HT1A receptor subtype. J Pharm Pharmacol, 2001. 53(10): p. 1419-26.
- [2]. Hayase, M., et al., Evolving mechanisms of action of alverine citrate on phasic smooth muscles. Br J Pharmacol, 2007. 152(8): p. 1228-38.
安全信息
GHS Symbol
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
其他信息
- Alverine citrate是一种治疗功能性肠胃病的药物。
- MOL 文件:5560-59-8.mol
- 阿尔维林 柠檬酸盐
- Sigma Aldrich:5560-59-8(sigmaaldrich)
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