Colfosceril palmitate 1,2-二棕榈酰-sn-甘油-3-磷酰胆碱
CAS 63-89-8 MFCD00036903
化学结构图
SMILES: CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC
化学属性
| Mol. Formula | C40H80NO8P |
|---|---|
| Mol. Weight | 734.04 |
| Melting Point | 229-229.5 °C |
别名和识别编码
| Chemical Name | Colfosceril palmitate |
|---|---|
| CAS Number | 63-89-8 |
| Synonym | DPPC {LY} DPPC {} {LY} DPPC {} {} {LY} DPPC {} {} {} {LY} DPPC {} {} {} {} {LY} DPPC {} {} {} {} {} {LY} DPPC {} {} {} {} {} {} {LY} DPPC {} {} {} {} {} {} {} {LY} DPPC {} {} {} {} {} {} {} {} {LY} DPPC {} {} {} {} {} {} {} {} {} {LY} DPPC {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} DPPC {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} DPPC {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} DPPC {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} DPPC {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} DPPC {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} DPPC {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} DPPC {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} DPPC {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { |
| MDL Number | MFCD00036903 |
| PubChem Substance ID | 452110 |
| EC Number | 200-567-6 |
| Reaxys-RN | 1917966 |
| Beilstein Registry Number | 1917966 |
| Merck Number | 2477 |
| Chemical Name Translation | 1,2-二棕榈酰-sn-甘油-3-磷酰胆碱 |
| LabNetwork Molecule ID | LN01314890 |
| InChI | InChI=1S/C40H80NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-39(42)46-36-38(37-48-50(44,45)47-35-34-41(3,4)5)49-40(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h38H,6-37H2,1-5H3/t38-/m1/s1 |
| Canonical SMILES | CCCCCCCCCCCCCCCC(O[C@H](COC(CCCCCCCCCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O)=O |
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分类
- {SNA} Bioactive Small Molecule Alphabetical Index, Biochemicals and Reagents, DIG-DY, Glycerophospholipid Metabolism, Glycerophospholipids, Glycerophosphonocholines, Lipids, L
- {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Signaling and Neuroscience, DIG-DY, Glycerophospholipid Metabolism, Glycerophospholipids, Glycerophosphonocholines, Lipids, Lipids in Cell Signaling, Metabolic Pathways,
- {Che
- {SNA} Glycerophospholipids, Glycerophosphonocholines, 代谢组学, 代谢通路, 生化试剂, 磷酸甘油酯代谢, 细胞生物学,
产品应用
- Colfosceril Palmitate is a major phospholipid constituent and primary surface tension lowering component of natural lung surfactant. Colfosceril Palmitate is used as pulmonary surfactant and diagnosti
相关文献及参考
- [2]. Akiko Uemura, et al. Induction of immune responses against glycosphingolipid antigens: comparison of antibody responses in mice immunized with antigen associated with liposomes prepared from various phospholipids. J Vet Med Sci. 2005 Dec;67(12):1197-201.
- Cha, S., et al.: J. Biol. Chem., 273, 2153 (1998),
- Pantusa, M., et al.: Biophys Chem., 114, 121 (2005),
- Pantusa, M., et al.: Eur. Biophys. J., 37, 961 (2008),
- [1]. Miller AD. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov;10(6):781-811.
- [1]. Miller AD. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov;10(6):781-811.
- [2]. Akiko Uemura, et al. Induction of immune responses against glycosphingolipid antigens: comparison of antibody responses in mice immunized with antigen associated with liposomes prepared from various phospholipids. J Vet Med Sci. 2005 Dec;67(12):1197-201.
安全信息
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
GHS Symbol
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
其他信息
- 上游原料:四丁酚醇
- Acros Organics:L-alpha-二棕榈酰磷脂酰胆碱 L-alpha-Dipalmitoyl phosphatidylcholine, 98%(63-89-8)
- MOL 文件:63-89-8.mol
- 方法一:合成表面活性剂，由棕榈胆磷加十六烷基醇和泰洛沙泊(Tyloxapo1)组成。
- 图谱信息:二棕榈酸磷脂酰胆碱(63-89-8)核磁图( 13 CNMR) 二棕榈酸磷脂酰胆碱(63-89-8)核磁图( 1 HNMR)
- Sigma Aldrich:63-89-8(sigmaaldrich)
- F:10-21
- 二棕榈酸磷脂酰胆碱价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 240571000 二棕榈酸磷脂酰胆碱 L-alpha-Dipalmitoyl phosphatidylcholine 98% 100 MG 879元 2010/06/21 240575000 二棕榈酸磷脂酰胆碱 L-alpha-Dipalmitoyl phosphatidylcholine 98% 500 MG 2587元 2010/06/21 240570025 二棕榈酸磷脂酰胆碱 L-alpha-Dipalmitoyl phosphatidylcholine 98% 2.5 GR 11016元
- 用途一:为天然表面活性物质，是外源性表面活性物质制剂的主要组分。用于抢救因RDS进行机械通气的出生体重700g以上的新生儿。
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