TPEN N1,N1,N2,N2-四(吡啶-2-基甲基)乙烷-1,2-二胺

CAS 16858-02-9 MFCD00036918

化学结构图

16858-02-9
SMILES: C(C1C=CC=CN=1)N(CC1C=CC=CN=1)CCN(CC1C=CC=CN=1)CC1C=CC=CN=1

化学属性

Mol. FormulaC26H28N6
Mol. Weight425
Melting Point110-114
TSCANo

别名和识别编码

Chemical NameTPEN
CAS Number16858-02-9
Synonym N,N,N?,N?-Tetrakis-pyridin-2-ylmethyl-ethane-1,2-diamine
MDL NumberMFCD00036918
PubChem Substance ID87577249
Beilstein Registry Number4211982
Reaxys-RN4211982
Chemical Name TranslationN1,N1,N2,N2-四(吡啶-2-基甲基)乙烷-1,2-二胺
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分类

  • Inhibitors
  • {SNA} ATRP, ATRP Ligands, Apoptosis and Cell Cycle, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA Synthesis Inhibitors, DNA metabolism, Materials Science, Polymer Science, Reagents for Controlled Radical Polymerization, Reagents for Polymerization, T
  • Heterocycles
  • {SNA} ATRP, ATRP Ligands, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, DNA Synthesis Inhibitors, DNA metabolism, Polymer Science, Reagents for Controlled Radical Polymerization, Reagents for Polymerization, T, 材料科学,
  • Chelating Agents & Ligands
  • {SNA} ATRP,
  • Apop

产品应用

  • Membrane-permeable zinc chelator; decreased the intracellular level of zinc and induced apoptosis.

相关文献及参考

  • [2]. Rahal ON, et al. Chk1 and DNA-PK mediate TPEN-induced DNA damage in a ROS dependent manner in human colon cancer cells. Cancer Biol Ther. 2016 Nov;17(11):1139-1148.
  • [3]. E Aizenman, et al. Induction of neuronal apoptosis by thiol oxidation: putative role of intracellular zinc release. J Neurochem. 2000 Nov;75(5):1878-88.
  • Chang, H.-R., et al.: J. Am. Chem. Soc., 112, 6814 (1990),
  • Kolenko, V.M.: Apoptosis, 6, 419 (2001),
  • Treves, S., et al.: Exp. Cell Res., 21, 339 (1994),
  • [1]. Ohkubo M, et al. Heavy metal chelator TPEN attenuates fura-2 fluorescence changes induced by cadmium, mercury and methylmercury. J Vet Med Sci. 2016 Jun 1;78(5):761-7.
  • [1]. Ohkubo M, et al. Heavy metal chelator TPEN attenuates fura-2 fluorescence changes induced by cadmium, mercury and methylmercury. J Vet Med Sci. 2016 Jun 1;78(5):761-7.
  • [2]. Rahal ON, et al. Chk1 and DNA-PK mediate TPEN-induced DNA damage in a ROS dependent manner in human colon

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P302+P352+P332+P313+P362+P364
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P332+P313
  • P305+P351+P338+P337+P313
  • P302+P350
  • P337+P313
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Signal word
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
Hazard Codes Xi
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. T - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. DNA metabolism - Apoptosis and Cell Cycle
  6. DNA Synthesis Inhibitors - DNA metabolism
  1. C6 to C7 - Pyridines
  1. C16+ - Pyridines
  1. Medical Research Areas
  2. Metabolism
  3. Reactive Oxygen Species  (活性氧)

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