Hydrocortisone 21-acetate 醋酸氢化可的松

CAS 50-03-3 MFCD00037714

化学结构图

50-03-3
SMILES: CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12C |&1:7,11,12,21,23,24,27|

化学属性

Mol. FormulaC23H32O6
Mol. Weight404.50
Melting Point223°C
TSCANo
Density1.26
Flash Point223°C
Appearance 25 白色或类白色结晶性粉末,无气味。Mp218-221.5℃; 比旋光度[α] +166°(二噁烷);乙醇溶液在240nm波长处有最大吸收。不溶于水,微溶于乙醇(1:230)和氯仿(1:150),难溶于乙醚。 D
Boiling Point576.6°C at 760 mmHg

别名和识别编码

Chemical NameHydrocortisone 21-acetate
CAS Number50-03-3
Synonym Hydrocortisone acetate {LY} Hydrocortisone acetate {} {LY} Hydrocortisone acetate {} {} {LY} Hydrocortisone acetate {} {} {} {LY} Hydrocortisone acetate {} {} {} {} {LY} Hydrocortisone acetate {} {} {} {} {} {LY} Hydrocortisone acetate {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrocortisone acetate {} {} {} {} {} {} {} {LY} Hydrocortisone acetate {} {} {} {} {} {} {} {} {LY} Hydrocortisone acetate {} {} {} {} {} {} {} {} {} {LY} Hydrocortisone acetate {} {} {} {} {} {} {} {} {} {} {LY} Hydrocortisone acetate {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrocortisone acetate {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrocortisone acetate {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrocortisone acetate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrocortisone acetate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrocortisone acetate {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00037714
PubChem Substance ID5744
Beilstein Registry Number2066841
EC Number200-004-4
Reaxys-RN2633529
Merck Number4787
Chemical Name Translation醋酸氢化可的松
Wiswesser Line NotationL E5 B666 OV MUTJ A CQ E FV1OV1 FQ -B&ACEF
LabNetwork Molecule IDLN00337030
InChIInChI=1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1
Canonical SMILESC[C@@]12[C@](C(COC(C)=O)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
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分类

  • {Chemicalbo
  • Alphabetic, Analytical Standards, Analytical/Chromatography, Antibiotics, Antibiotics A to Z, Antibiotics G-M, Bioactive Small Molecules, Cell Biology,
  • {SNA} Antibiotics, Antibiotics A to Z, Antibiotics G-M, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Core Bioreagents, Enzyme Inhibitors, H, Research Essentials
  • {SA} Antibiotics, Antibiotics A to Z, Antibiotics G-M, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Corticosteroid, Cytokines, Gr

产品应用

  • Glucocorticoid.

相关文献及参考

  • Merck: 14,4787 Beilstein: 8,IV,3424
  • Middleton, B
  • Merck: 14,4787

安全信息

RTECSGM8960000
GHS Symbol
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P312
  • P302+P352
  • P304+P312
  • P304+P340
  • P308+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H332 Harmful if inhaled 吸入有害
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
Hazard Codes Xn
WGK Germany3
Signal word {} {} {} {TCI}
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
Risk Statements
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges dust mask type N95 (US), Eyeshields, Gloves
Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 45050 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 27,2102,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 60 mg/kg
REFERENCE :
   OFAJAE Okajimas Folia Anatomica Japonica.  (Keio Univ., School of Medicine,
   Dept. of Anatomy, 35 Shinano-machi, Shinjuku-ku, Tokyo 160, Japan)  V.14-
   1936-  Volume(issue)/page/year: 51,1,1974

TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 150 mg/kg
REFERENCE :
   BEXBAN Bulletin of Experimental Biology and Medicine (English Translation).
   Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
   10013)  V.41-    1956-  Volume(issue)/page/year: 77,437,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - pig
DOSE                    : 100 mg/kg
SEX/DURATION            : female 12 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 64,85,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - ra

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 50 mg/kg
SEX/DURATION            : female 14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 30(1),11A,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2 mg/kg
SEX/DURATION            : female 2-5 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   ENDOAO Endocrinology (Baltimore).  (Williams & Wilkins Co., 428 E. Preston
   St., Baltimore, MD 21203) V.1-    1917-  Volume(issue)/page/year:
   81,1091,1967

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OB

TYPE OF TEST            : TDLo -

其他信息

  • 上游原料:吡啶 --> 氢化可的松 --> 皂素
  • TCI Shanghai:乙酸氢化可的松 Hydrocortisone Acetate,>;96.0%(E)(50-03-3)
  • 用途三:糖皮质激素,具有抗炎、抗过敏、抗毒素、抗体克作用。
  • 用途一:糖皮质激素类药,具有抗炎、抗过敏、抗毒素、抗休克作用
  • 参考质量标准:含量97.0%-103.0%;mp216-224℃;比旋光度[α] 20 D +158°-+165°;检测其他甾体及干燥失重等杂质含量。
  • Alfa Aesar:氢化可的枪乙酸,97+% Hydrocortisone acetate, 97+%(50-03-3)
  • 方法一:氢化可的松和醋酐在吡啶中酯化制得。
  • 醋酸氢化可的松价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 H0184 乙酸氢化可的松 Hydrocortisone Acetate 5G 690元 2014/06/02 H0184 乙酸氢化可的松 Hydrocortisone Acetate 1G 190元 2010/05/25 A18089 氢化可的枪乙酸, 97+% Hydrocortisone acetate, 97+% 5g 1128元
  • 醋酸氢化可的松价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 H0184 乙酸氢化可的松 Hydrocortisone Acetate 5G 743元 2011/04/16 H0184 乙酸氢化可的松 Hydrocortisone Acetate 1G 332元 2010/05/25 A18089 氢化可的枪乙酸, 97+% Hydrocortisone acetate, 97+% 5g 1128元
  • Sigma Aldrich:50-03-3(sigmaaldrich)
  • 用途二:生化研究,肾上腺皮质激素类药物。
  • 图谱信息:醋酸氢化可的松(50-03-3)红外图谱(IR2) 醋酸氢化可的松(50-03-3)红外图谱(IR1) 醋酸氢化可的松(50-03-3)质谱(MS)
  • Decomposition:223 °C
  • MOL 文件:50-03-3.mol

系列性分类


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