Corticosterone 皮质甾酮

CAS 50-22-6 MFCD00037715

化学结构图

50-22-6
SMILES: C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)CO

化学属性

Mol. FormulaC21H30O4
Mol. Weight346
Melting Point180-183
Density1.21
SolubilitySoluble in acetone, methanol, ethanol (10 mM), chloroform, and DMSO (100 mM). Insoluble in water.

别名和识别编码

Chemical NameCorticosterone
CAS Number50-22-6
Synonym Corticosteron 皮质酮 11ß,21-dihydroxypregn-4-ene-3,20-dione 11ß,21-dihydroxy-pregn-4-ene-3,20-d 11β 11ß, 21-Dihydroxyprogesterone Reichstein's substance H 肾上腺酮,可的松,皮质酮,11β,21-二羟基-孕烯-3,20-酮, 11β,21-二羟基孕酮 11β,21-二羟基-孕烯-3 4-PREGNEN-11B,21 11BETA,21-DIHYDROXY-PROGESTERONE (11?)-11,21-Dihydroxy-pregn-4-ene-3,20-dione 11ß,21-Dihydroxypregn-3,20-dione 11β, 21-Dihydroxyprogesterone KENDALL'S COMPOUND ''B'' NS (11-beta)-11,21-Dihydroxypregn-4-ene-3,20-dione Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11-beta)- 17-Deoxycortisol CORTICOSTERONE {uni_ha 可的松 11-Hydroxycorticoaldosterone 11β,2 肾上腺酮,可的松,11β,21-二羟基-孕烯-3,20-酮, 11β,21-二羟基孕酮, 皮质酮 Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11ß)- 4-PREGNENE-11BETA,21-DIOL-3,20-DIONE 11BETA,21-DIHYDROXY-4-PRENENE-3,20-DIONE 11-beta,21-Dihydroxypregn-3,20-dione 4-Pregnene-11ß,21-diol-3,20-dione DELTA4-PREGNEN-11BETA, 21-DI 11,21-Dihydroxyprogesterone Kendall's compound B Kendall's compound B 11β,21-二羟基-孕烯-3,20-酮 肾上腺酮 NSC-9705 Pregn-4-ene-3,20-dione, 11β, 21-dihydroxy- Preg RE 11ß,21-Dihydroxyprogesterone 11β,21-dihydroxy-pregn-4-ene-3,20-dione {Chemicalbook 皮质酮;肾上腺酮; NSC 9705 4-Pregnene-11-beta,21-diol-3,20-dione 11BETA,21-DIHYDROXYPREGN-4-ENE-3,20-DIONE 4-PREGNEN-11-BETA, 21-DIOL-3,20-DIONE 11,12-dihydroxyprogesterone 11-beta,21-Dihydroxyprogesterone 11β,21-Dihydroxypregn- 皮质
MDL NumberMFCD00037715
PubChem Substance ID87565517
Beilstein Registry Number2339601
EC Number200-019-6
Reaxys-RN2339601
Merck Number2538
Chemical Name Translation皮质甾酮
Wiswesser Line NotationL E5 B666 OV MUTJ A1 CQ E1 FV1Q
LabNetwork Molecule IDLN00195818
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分类

  • {SNA} Additional Standards, Analytical Standards, Application Areas and Market Segments, Biomarkers and Metabolomics Standards, Hormone Standards,
  • {SNA} Bioactive Small Molecules, Biochemicals and Reagents, CI-CY, Cell Signaling and Neuroscience, Corticosteroid, Cytokines, Growth Factors and Hormones, Hormones, Lipids, Metabolic Pathways, Steroid Hormones, Steroid Metabolism, Steroids (C21) and Derivatives,
  • {SNA} Bioactive Small Molecule Alphabetical Index, CI-CZ, Corticosteroid, Cytokines, Growth Factors and Hormones, Hormones, Steroid Hormones, Steroids (C21) and Derivatives, Sterol Lipids,

产品应用

  • Corticosteroid is an activator of MCR.

相关文献及参考

  • Afadlal, S., et al., Prenatal Stress Alters Presynaptic Marker Proteins In The Hippocampus Of Rat Pups. Neurosci. Lett. 470 , 24-7, (2010) 摘要
  • Bailey, M., et al.: J. Immunol., 182, 7888 (2009),
  • Brunton, P., et al.: J. Neurosci., 29, 6449 (2009),
  • Campbell, J.E., et al., Adipogenic And Lipolytic Effects Of Chronic Gluco
  • Graham, C.E., and Vetter, D.E., The Mouse Cochlea Expresses A Local Hypothalamic-pituitary-adrenal Equivalent Signaling System And Requires Corticotropin-releasing Factor Receptor 1 To Establish Normal Hair Cell Innervation And Cochlear Sensitivity. J. Neurosci. 31 , 1267-78, (2011) 摘要
  • Jankowski, M.D., et al., Testing Independent And Interactive Effects Of Corticosterone And Synergized Resmethrin On The Immune Response To West Nile Virus In Chickens. Toxicology 269 , 81-8, (2010) 摘要
  • Merck: 14,2538
  • Merck: 14,2538 Beilstein:8(3)3574
  • Newman, A.E., et al., Corticosterone And Dehydroepiandrosterone Have Oppos

安全信息

RTECSGM7650000
GHS Symbol
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Hazard statements
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
Hazard Codes Xi
WGK Germany3
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Signal word Warning
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
Storage condition 储存温度2-8℃ 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Cells - not otherwise specified
DOSE/DURATION           : 100 nmol/L
REFERENCE :
   ECREAL Experimental Cell Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.10-    1950-  Volume(issue)/page/year: 161,29,1985

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Bird - chicken Embryo
DOSE/DURATION           : 1500 pmol/L
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 257,804,1975

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Human Liver
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 370,49,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 500 mg/kg
SEX/DURATION            : female 8-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   AGDJAI Journal of the Academy of General Dentistry.  (Academy of General
   Dentistry, 211 E. Chicago Ave., Suite 1200, Chicago, IL 60611)  V.1-
   1952(?)-  Volume(issue)/page/year: 18,34,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1472 mg/kg
SEX/DURATION            : female 11-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 176,14,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 84 mg/kg
SEX/DURATION            : female 16-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   NRSCDN Neuroscience.  (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3
   OBW, UK)  V.1-    1976-  Volume(issue)/page/year: 66,467,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 40 mg/kg
SEX/DURATION

其他信息

  • MOL 文件:50-22-6.mol
  • TCI Shanghai:皮质甾酮 Corticosterone,>;97.0%(LC)(50-22-6)
  • Sigma Aldrich:50-22-6(sigmaaldrich)
  • 肾上腺酮价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C0388 皮质甾酮 Corticosterone 5G 4930元 2014/06/02 C0388 皮质甾酮 Corticosterone 1G 1360元 2014/06/02 C0388 皮质甾酮 Corticosterone 100MG 273元
  • 肾上腺酮价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 C0388 皮质甾酮 Corticosterone 5G 4750元 2011/04/16 C0388 皮质甾酮 Corticosterone 1G 1310元 2011/04/16 C0388 皮质甾酮 Corticosterone 100MG 263元
  • 图谱信息:肾上腺酮(50-22-6)红外图谱(IR1) 肾上腺酮(50-22-6)红外图谱(IR2) 肾上腺酮(50-22-6)质谱(MS)

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. CI-CY - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Lipids - Biochemicals and Reagents
  4. Sterol Lipids - Lipids
  5. Steroids (C21) and Derivatives - Sterol Lipids
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Market Segments - Analytical Standards
  4. Standards for Pharma Clinical Forensic & Veterinary Analysis - Market Segments
  5. Neats and Solutions - Standards for Pharma Clinical Forensic & Veterinary Analysis
  6. Hormones - Neats and Solutions
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Corticosteroid - Steroid Hormones
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Corticosterone
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Steroids
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Glucocorticoid Receptor  (糖皮质激素受体)
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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