((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate ((2R,3S,4R,5R)-5-(3-氨甲酰吡啶-1-鎓-1-基)-3,4-二羟基四氢呋喃-2-基)甲基磷酸氢酯
CAS 1094-61-7 MFCD00038748
化学结构图
SMILES: NC(=O)c1ccc[n+]([C@@H]2O[C@H](COP(=O)([O-])O)[C@@H](O)[C@H]2O)c1
化学属性
| Mol. Formula | C11H15N2O8P |
|---|---|
| Mol. Weight | 334 |
| Melting Point | 166 |
别名和识别编码
| Chemical Name | ((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate |
|---|---|
| CAS Number | 1094-61-7 |
| Synonym | ######## β-Nicotinamide mononucleotide Mononucleotide, Nicotinamide Nicotinamide Mononucleotide β-NMN β-Nicotinamide ribose monophosphate NMN Nicotinamide ribotide Nicotinamide-1-ium-1-β-D-ribofuranoside 5'-phosphate β-Nicotinamide ribose monophosphate |
| MDL Number | MFCD00038748 |
| Beilstein Registry Number | 3570187 |
| EC Number | 214-136-5 |
| PubChem Substance ID | 14180 |
| Chemical Name Translation | ((2R,3S,4R,5R)-5-(3-氨甲酰吡啶-1-鎓-1-基)-3,4-二羟基四氢呋喃-2-基)甲基磷酸氢酯 |
| Reaxys-RN | 3570187 |
| Merck Number | 6663 |
| LabNetwork Molecule ID | LN01326306 |
| InChI | InChI=1S/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8-,9-,11-/m1/s1 |
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分类
- Bases & Related Reagents
- {SNA} Cofactors, Oxidation-Reduction, 生化试剂, 酶、抑制剂和底物
- Nucleotides
- Nicotine Derivatives
- Pharmaceuticals
- Amines
- Aromatics
- Intermediates & Fine Chemicals,
- {SNA} Biochemicals and Reagents, Cofactors, Enzymes, Inhibitors, and Substrates, Oxidation-Reduction
产品应用
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相关文献及参考
- [2]. Lv H, et al. NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion [published online ahead of print, 2020 Nov 3]. Cell Metab. 2020;S1550-4131(20)30554-4.
- [3]. Li J, et al. p53 prevents doxorubicin cardiotoxicity independently of its prototypical tumor suppressor activities. Proc Natl Acad Sci U S A. 2019;116(39):19626-19634.
- [4]. Yoshino J, et al Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011;14(4):528-536.
- Yoshino, J. et al.: Cell Metab., 14, 528 (2011); Caton, P.W. et al.: Diabetologia, 54, 3083 (2011); Formentini, L. et al.: BIochem. Pharmacol., 77, 1612 (2009);
- [1]. Poddar SK, et al. Nicotinamide Mononucleotide: Exploration of Dive
- [1]. Poddar SK, et al. Nicotinamide Mononucleotide: Exploration of Diverse Therapeutic Applications of a Potential Molecule. Biomolecules. 2019;9(1):34. Published 2019 Jan 21.
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