Obidoxime chloride 双复磷

CAS 114-90-9 MFCD00038864

化学结构图

114-90-9
SMILES: ON=Cc1cc[n+](COC[n+]2ccc(C=NO)cc2)cc1.[Cl-].[Cl-]

化学属性

Mol. FormulaC14 H16 N4 O3 . 2 Cl
Mol. Weight359.21
Boiling Point
Melting Point>208°C (dec.)
Flash Point-

别名和识别编码

Chemical NameObidoxime chloride
CAS Number114-90-9
Synonym 1,1′-(Oxydimethylene)bis(pyridinium-4-carbaldoxime) dichloride 1,1'-(Oxybis(methylene))bis(4-(hydroxyimino)methyl)pyridinium dichloride 1,1'-(Oxydimethylene)bis(4-formylpyridinium) dioxime dichloride 1,1'-(Oxydimethylene)bis(4-formylpyridinium)dichloride dioxime 1,1'-(Oxydimethylene)bis(pyridinium-4-carbaldoxime) dichloride Bis(4-formylpyridiniomethyl) ether dioxime Toxogonin 1,1?[Oxybis(methylene)]-bis[4-(hydroxyimino)methyl]pyridinium Dichloride 1,3-Bis(4-aldoximinopyridinium) dimethyl ether bichloride 1,3-Bis(4-hydroxyiminomethyl-1-pyridinio)-2-oxapropane dichloride BH 6 BU-6 Bis(4-formylpyridiniomethyl) ether dioxime Bis(4-hydroxyiminomethylpyridinium-1-methyl)ether dichloride Bis(isonicotinaldoxime 1-methyl) ether dichloride Chloride, Obidoxime Ether bis-14-hydroxy-iminomethylopyridine-(1)-mety
MDL Number-
PubChem Substance ID135566074
Beilstein Registry Number4117377
EC Number204-059-5
Chemical Name Translation双复磷
Wiswesser Line NotationT6KJ D1UNQ A1O1- AT6KJ D1UNQ &G 2
LabNetwork Molecule IDLN02124500
InChIInChI=1S/C14H14N4O3.2ClH/c19-15-9-13-1-5-17(6-2-13)11-21-12-18-7-3-14(4-8-18)10-16-20;;/h1-10H,11-12H2;2*1H
Canonical SMILES-
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分类

  • {SNA} Analytical Standards, Analytical and Industrial Enzymes, Analytical/Chromatography, Biochemicals and Reagents, Cholinesterase and Organophosphate Detection Reagents, Chromatography, Life Sciences Standards, Oxime-Based Reactivators of Cholinesterase, Pharmacology Standards, 酶、抑制剂和底物
  • {SNA} Analytical an
  • {SNA} Analytical and Industrial Enzymes, Biochemicals and Reagents, Cholinesterase and Organophosphate Detection Reagents, Enzyme Inhibitors,
  • {SNA} Analytical Standards, Analytical
  • {SNA}
  • {SNA} Analytical and Industrial Enzymes, Cholinesterase and Organophosphate Detection Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Type, Organic Covalent Modifiers, Oxime-Based Reactivators of Cholinesterase, 生化试剂, 酶、抑制剂和底物

产品应用

  • Cholinesterase reactivator.

相关文献及参考

  • 1. R.M. Dawson J. Appl. Toxicol. 14 , 317, (1994) 摘要
  • 2. Worek, F., et al., Reactivation of organophosphate-inhibited human AChE by combinations of obidoxime and HI 6 in vitro J. Appl. Toxicol. 27 , 582-588, (2007) 摘要
  • Merck 14 ,6738

安全信息

WGK Germany2
RTECSUU6825000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 111 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   3,533,1983

{

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 14,5,1964

{hazar

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 183 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 38,168,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 79 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   16,40,1970

TYPE

Storage condition -20 -20°C -20℃

系列性分类


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