Diethylcarbamazine Citrate 枸橼酸二乙碳酰嗪

CAS 1642-54-2 MFCD00039124

化学结构图

1642-54-2
SMILES: CCN(CC)C(=O)N1CCN(C)CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O

化学属性

Mol. FormulaC10H21N3O
Mol. Weight391
Melting Point140 °C

别名和识别编码

Chemical NameDiethylcarbamazine Citrate
CAS Number1642-54-2
Synonym ######## 1-(N,N-DIETHYLCARBAMOYL)-4-METHYLPIPERAZINE CITRATE 1-Diethylcarbamoyl-4-methylpiperazine dihydrogen citrate 1-Methyl-4-diethylcarbamoylpiperazine citrate 1-diethylcarbamoyl-4-methylpiperazi 1-diethylcarbamoyl-4-methylpiperazinedihydrogencitrate[qr] 1-methyl-4-diethylcarbamoylpiperazinecitrate 1-methyl-4-diethylcarbamoylpiperazinecitrate[qr] 1-piperazinecarboxamide,n,n-diethyl-4-methyl-,2-hydroxy-1,2,3-p 1-piperazinecarboxamide,n,n-diethyl-4-methyl-,2-hydroxy-1,2,3-propanetricarbo 1-二乙胺基甲酰基-4-甲基哌嗪 柠檬酸盐 Banocide Carbamazine Caritrol Carricide citrate Citrate, Diethylcarbamazine DIETHYLCARBAMAZINE CITRATE DIETHYLCARBAMAZINE CITRATE SALT Diethylcarbamazane citrate Diethylcarbamazine Diethylcarbamazine Citrate
MDL NumberMFCD00039124
PubChem Substance ID15432
Beilstein Registry Number3836352
EC Number216-696-6
Reaxys-RN3836352
Chemical Name Translation枸橼酸二乙碳酰嗪
Wiswesser Line NotationT6N DNTJ AVN2&2 D1 &OV1XQVO&1VO
LabNetwork Molecule IDLN00241169
InChIInChI=1S/C10H21N3O.C6H8O7/c1-4-12(5-2)10(14)13-8-6-11(3)7-9-13;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-9H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
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分类

  • {SNA} Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antiparasitic / Antiprotozoal / Anthelminthic, Biochemicals and Reagents, Building Blocks, C16 to C29, Chemical Synthesis, Heterocyclic Building Blocks, Piperazines, Spectrum of Activity
  • {SNA} Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antiparasitic / Antiprotozoal / Anthelminthic, Biochemicals and Reagents, Spectrum of Activity
  • {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards C - D, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
  • {SNA} Analytical Standards,
  • {SNA} Antibiotics A to Z,

产品应用

  • Diethylcarbamazine Citrate can be used as an anthelmintic. The LD50 in rats is 1.38 g/kg.

相关文献及参考

  • MacKenzie, C.D. and Kron, M.A.: Trop. Dis. Bull., 82(10), R1-R37 (1985); Harned et al.: Ann. N. Y. Acad. Sci., 50, 141 (1948)

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P312
  • P301+P312+P330
  • P301+P317
  • P304+P340
  • P304+P340+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P316
  • P320 Specific treatment is urgent (see … on this label). 紧急具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H330 Fatal if inhaled 吸入致命
RTECSTL1225000
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Signal word Danger
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S22 Do not breathe dust 不要吸入粉尘;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
Hazard Codes T T+
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R23 Toxic by inhalation 吸入有毒
  • R26 Very toxic by inhalation 吸入极毒
Packing GroupII
UN Number UN 2811 6.1/PG 2 2811
Hazard Class6.1
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 660 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland,
   OH, Chemical Rubber Co., 1969  Volume(issue)/page/year: -,41,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAZMAE Fortschritte der Arzneimittelforschung.  Progress in Drug Research.
   (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way,
   Secaucus, NJ 07094)  V.1-    1959-  Volume(issue)/page/year: 17,108,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 608 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,306,1982

TYPE OF TEST

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1136 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,306,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1800 mg/kg
SEX/DURATION            : female 8-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   IJMRAQ Indian Journal of Medical Research.  (Indian Council of Medical
   Research, Ansari Nagar, New Delhi 110 029, India)  V.1-    1913-
   Volume(issue)/page/year: 60,1529,1972

其他信息

  • MOL 文件:1642-54-2.mol
  • Sigma Aldrich:1642-54-2(sigmaaldrich)
  • 图谱信息:枸橼酸乙胺嗪(1642-54-2)红外图谱(IR1) 枸橼酸乙胺嗪(1642-54-2)质谱(MS) 枸橼酸乙胺嗪(1642-54-2)红外图谱(IR2)
  • TCI Shanghai:N,N-二乙基-4-甲基-1-哌嗪甲酰胺柠檬酸盐 Diethylcarbamazine Citrate,>;98.0%(T)(1642-54-2)
  • 枸橼酸乙胺嗪价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 D1898 枸橼酸二乙碳酰嗪 Diethylcarbamazine Citrate 10G 565元

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