Tri-O-Tolyl Phosphate 邻磷酸三甲酚酯

CAS 78-30-8 MFCD00041906

化学结构图

78-30-8
SMILES: Cc1ccccc1OP(=O)(Oc1ccccc1C)Oc1ccccc1C

化学属性

Mol. FormulaC21H21O4P
Mol. Weight368.36
Refractive index1.5590 to 1.5620
Melting Point-25 °C
Density1.2
Boiling Point410 °C at 760 mmHg
Flash Point225°C(lit.)
Appearance 无色或淡黄色透明油状液体。沸点410℃(部分分解),相对密度1.183(25/4℃)。易溶于醇、醚和苯,几乎不溶于水。工来上以混合甲酚为原料得到的磷酸三甲酚酯(异构体混合物),CA登录号为[1330-78-5]。凝固点-35℃;沸点265℃(1.33kPa)。
pH:A

别名和识别编码

Chemical NameTri-O-Tolyl Phosphate
Synonym Tri-O-tolyl phosphate {LY} Tri-O-tolyl phosphate {} {LY} Tri-O-tolyl phosphate {} {} {LY} Tri-O-tolyl phosphate {} {} {} {LY} Tri-O-tolyl phosphate {} {} {} {} {} {} {} {} {LY} Tri-O-tolyl phosphate {} {} {} {} {} {LY} Tri-O-tolyl phosphate {} {} {} {} {} {} {LY} Tri-O-tolyl phosphate {} {} {} {} {} {} {} {LY} Tri-O-tolyl phosphate {} {} {} {} {} {} {} {} {LY} Tri-O-tolyl phosphate {} {} {} {} {} {} {} {} {} {LY} Tri-O-tolyl phosphate {} {} {} {} {} {} {} {} {} {} {LY} Tri-O-tolyl phosphate {} {} {} {} {} {} {} {} {} {} {} {LY} Tri-O-tolyl phosphate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Tri-O-tolyl phosphate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Tri-O-tolyl phosphate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Tri-O-tolyl phosphate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Tri-O-
MDL NumberMFCD00041906
CAS Number78-30-8
EC Number201-103-5
Reaxys-RN1892885
PubChem Substance ID87575419
Merck Number9764
Chemical Name Translation邻磷酸三甲酚酯
Wiswesser Line Notation1R BOPO&OR B1&OR B1
Beilstein Registry Number1892885
LabNetwork Molecule IDLN01305315
Canonical SMILESCC1=CC=CC=C1OP(OC2=CC=CC=C2C)(OC3=C(C)C=CC=C3)=O
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分类

  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 1fragment

相关文献及参考

  • Short: III/38A Title: Refractive Indices of Inorganic, Organometallic, and Organononmetallic Liquids and Binary Liquid Mixtures Author: Wohlfarth, Ch.; Wohlfarth, B. Editor: Lechner, M.D. Source: Landolt-Börnstein, New Series Volume: III/38A Year: 1996 Keyword: organicmetallic compounds; inorganic compounds; refractive index; liquids; mixtures ISBN: 3-540-60539-8 ISBN: 978-3-540-60539-3 Internet Resource: DOI:10.1007/b55612 RefComment: VII, 400 pages, Hardcover Abstract: Volume III/38 Optical Constants provides critically evaluated data on refractive indices of inorganic and organic liquids and their wavelength dependence (dispension). Part A contains the inorganic, organometallic, and organononmetallic liquids, and the binary liquid mixtures (about 900 pure substances and their mixtures). Part B contains data of more than 7600 organic liquids.
  • Short: IV/18A Title: Viscosity of Pure Organic Liquids and Binary Liquid Mixtures: Pure Organometallic and Organononmetallic Liquids, Binary Liquid Mixtures Author: Wohlfarth, Ch.; Wohlfarth, B. Editor: Lechner, M.D. Source: Landolt-Börnstein, New Series Volume: IV/18A Year: 2001 Keyword: organic compounds; viscosity; liquids; mixtures ISBN: 3-540-64584-5 ISBN: 978-3-540-64584-9 Internet Resource: DOI:10.1007/b68239 RefComment: VII, 409 pages.
  • Short: IV/20B Title: Vapor Pressure and Antoine Coefficients for Oxygen Containing Organic Compounds Author: Dykyj, J.; Svoboda, J.; Wilhoit, R.C.; Frenkel, M.; Hall, K.R. Editor: Hall, K.R. Source: Landolt-Börnstein, New Series Volume: IV/20B Year: 2000 Keyword: organic compounds; vapor pressure ISBN: 3-540-64968-9 ISBN: 978-3-540-64968-7 Internet Resource: DOI:10.1007/b71424 RefComment: VII, 320 pages.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc

安全信息

RTECSTD0350000
Packing GroupII
UN Number 2574
Signal word
Hazard statements
  • H370 Causes damage to organs 导致器官损伤
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P308+P311
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P405 Store locked up. 上锁保管。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P307+P311
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
Hazard Codes
Hazard Class6.1
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S20/21 When using do not eat, drink or smoke 使用时,不得进食,饮水或吸烟;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
Risk Statements
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >3700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   41,291,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EQSFAP Environmental Quality and Safety.  (Stuttgart, Fed. Rep. Ger.) V.1-5,
   1972-76.  Discontinued.  Volume(issue)/page/year: 3,173,1974

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Lungs, Thorax, or Respiration - structural or functional change in trachea
   or bronchi
   Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 168,473,1932

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EQSFAP Environmental Quality and Safety.  (Stuttgart, Fed. Rep. Ger.) V.1-5,
   1972-76.  Disc

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 500 mg/kg/10D (Continuous)
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 14,2039,1993

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3150 mg/kg
SEX/DURATION            : male 21 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   89,64,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 450 mg/kg
SEX/DURATION            : male 3 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - other effects on male
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   89,64,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2100 mg/kg
SEX/DURATION            : female 14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   107,35,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1500 mg/kg
SEX/DURATION            : male 10 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Acad

Storage condition 2-8°C, protect from light, stored under nitrogen {LY} 2-8°C, protect from light, stored under nitrogen {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitr

其他信息

  • Acros Organics:邻磷酸三甲酚酯/三邻甲苯磷酸酯 Tri-o-tolyl phosphate, 96%(78-30-8)
  • MOL 文件:78-30-8.mol
  • 邻磷酸三甲酚酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 P1331 磷酸三邻甲苯酯 Tri-o-cresyl Phosphate 25G 1440元 2014/06/02 P1331 磷酸三邻甲苯酯 Tri-o-cresyl Phosphate 5G 480元 2010/06/21 366465000 邻磷酸三甲酚酯 Tri-o-tolyl phosphate 96% 500 GR 5406元
  • Sigma Aldrich:78-30-8(sigmaaldrich)
  • 上游原料:邻甲酚 --> 甲酚 --> 磷酸三甲苯酯
  • 方法一:以邻甲酚(或混合甲酚)为原料,与三氯化磷混合,于40℃左右反应半小时,反应放出氯化氢而得到亚酯。通氯氧化,将亚酯转化为酰氯酯,然后于50℃左右滴水水解成为磷酸三甲酚酯,经中和洗涤、蒸发脱水、减压蒸馏,即获得成品。
  • TCI Shanghai:磷酸三(邻甲苯)酯 Tri-o-cresyl Phosphate,>;96.0%(GC)(78-30-8)
  • 用途一:该品为主增塑剂,有很好的阻燃性、防霉性、耐磨性,挥发性低、电气性能好。主要用于聚氯乙烯电缆料、人造革、动输带、薄板、地板料等,也可用于氯丁橡胶。在粘胶纤维中作增塑剂和防腐剂。该品有毒,对中枢神经有毒害作用,不可用于食品和医药包装材料、奶嘴、儿童玩具等。

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