Dimethyl Phosphite 亚磷酸二甲酯

CAS 868-85-9 MFCD00044633

化学结构图

868-85-9
SMILES: CO[PH](=O)OC

化学属性

Mol. FormulaC2H7O3P
Mol. Weight110.06
Refractive indexn20/D 1.402(lit.)
Boiling Point170-171 °C(lit.)
Density1.2 g/mL at 25 °C(lit.)
Flash Point85 ºF
TSCAYes
Appearance 1.4009，相对密度1.2004，易溶于醇、醚等有机溶剂。 本品为无色油状液体，b.p.265℃，n D 20

别名和识别编码

Chemical NameDimethyl Phosphite
CAS Number868-85-9
PubChem Substance ID6327114
EC Number212-783-8
Beilstein Registry Number1697490
MDL NumberMFCD00044633
Synonym Dimethyl hydrogenphosphonate Phosphonic acid, dimethyl ester Dimethyl phosphonate Dimethylfosfit Dimethylfosfonat Dimethyl hydrogen phosphite Methyl phosphite, (MeO)2(HO)P 亚磷酸二甲酯 Dimethyl phosphite (DMP) dimethylphosphorousacid phosphonic acid dimethyl ester PHOSPHONIC ACID DIMETHYL ESTER (CH3O)2PHO Dimethylhydrogenphosphit NCI-C54773 dimethylphosphite DIMETHYL PHOSPHONATE bis(hydroxymethyl)phosphineoxide 亚磷酸二甲酯, 98+% DIMETHYL HYDROGEN PHOSPHITE Bis(hydroxymethyl)phosphine oxide Hydrogen dimethyl phosphite dimethylacidphosphite Dimethylester kyseliny fosforite dimethylesterkyselinyfosforite Dimethylhydrogenphosphite Dimethyl hydrogen phosphonate {uni_ha Phosphorous acid dimethyl ester dimethylhydrogenphosphonate Dimethyl ester of phosphonic acid Phosphorous acid, dimethyl ester Dimethyl phosphorous acid DMP Dimethyl hydrogen phosphite; Dimethyl phosphite Dimethylphosp Dimethoxyphosphine oxide dimethylesterkyselinifosforite(czech) Dimethylphosphorous acid Dimethyl acid phosphite Dimethylphosphit DIMETHYL PHOSPHITE Phosphonsäuredimethylester Dimethyl phosphate 磷酸二甲酯 dimethoxyphosphineoxide Phosphorigsäuredimethylester PHOSPHOROUS ACID DIMETHYL ESTER Methyl phosphonate ((MeO)2HPO)
Chemical Name Translation亚磷酸二甲酯
Wiswesser Line Notation1OPHO&O1
InChIInChI=1S/C2H6O3P/c1-4-6(3)5-2/h1-2H3/q+1
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分类

  • Building Blocks, Chemical Synthesis, Organic Building Blocks, Organic Phosphates/Phosphites, Phosphorus Compounds
  • {uni_hamburg} no charge; 1fragment
  • {SNA} Building Blocks, Chemical Synthesis, Organic Building Blocks, Organic Phosphates/Phosphites, Phosphorus Compounds
  • {Chemicalbook} 农药中间体: 杀虫剂中间体: 有机磷类杀虫剂

相关文献及参考

  • Beil. 1 ,IV,1255
  • Fieser 1 ,293 / Fieser 4 ,188 / Fieser 5 ,258
  • Aldrich MSDS 1 , 795:A / Corp MSDS 1 (1), 1408:B / FT-NMR 1 (1), 1471:A / IR-Spectra (3), 549:D / IR-Spectra (2), 487:A / NMR-Reference 2 (2), 864:C / RegBook 1 (1), 1097:E / Sax 6 , 1167 / Structure Index 1 , 169:B:8
  • Short: III/35A Title: Nuclear Magnetic Resonance (NMR) Data: Chemical Shifts and Coupling Constants for Boron-11 and Phosphorus-31 Author: Gupta, R.R.; Jain, M.; Pardasani, P.; Pardasani, R.T.; Pelter, A. Editor: Gupta, R.R.; Lechner, M.D. Source: Landolt-Börnstein, New Series Volume: III/35A Year: 1997 ISBN: 3-540-60366-2 ISBN: 978-3-540-60366-5 Internet Resource: DOI:10.1007/b53033 RefComment: VIII, 242 pages. With CD-ROM. Hardcover Abstract: This volume provides a comprehensive and evaluated compilation of nuclear magnetic resonance data. Chemical shifts and coupling constants of boron-11 and phosphorus-31 (subvol. A), fluorine-19 and nitrogen-15 (subvol. B), hydrogen-1 (subvol. C), and carbon-13 (subvol. D) compounds are tabulated together with the gross- and structure formulas and the most readily available solvents. Due to the large amount of the data merely chemical shifts are presented in the printed versions, and all the data, chemical shifts and coupling constants are provided on CO-ROM's.
  • Short: III/35C4 Title: Nuclear Magnetic Resonance (NMR) Data: Chemical Shifts and Coupling Constants for Hydrogen-1, Part 4: Inorganic and Organometallic Compounds Author: Gupta, R.R.; Platzer, N. Editor: Gupta, R.R.; Lechner, M.D. Source: Landolt-Börnstein, New Series Volume: III/35C4 Year: 2001 Keyword: Hydrogen 1; Nuclear Magnetic Resonance ISBN: 3-540-41059-7 ISBN: 978-3-540-41059-1 Internet Resource: DOI:10.1007/b76570 RefComment: VII, 299 pages. With CD-ROM. Hardcover Abstract: This volume provides a comprehensive and evaluated compilation of nuclear magnetic resonanc

安全信息

GHS Symbol
WGK Germany1
Hazard statements
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes Xn
RTECSSZ7710000
Precautionary statements
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
Signal word Danger
Risk Statements
  • R21 Harmful in contact with skin 与皮肤接触有害
  • R36 Irritating to eyes 刺激眼睛
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R10 Flammable 易燃
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Storage condition Moisture Sensitive
UN Number UN 3278 6.1/PG 3 1992
Packing GroupIII
Hazard Class3.2
Restrict 监控化学品 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 103 gm/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Gastrointestinal - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-287,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2970 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPEC

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 900 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - other (direct) parasympathomimetic
   Lungs, Thorax, or Respiration - respiratory stimulation
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 36(4),22,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ALBRW* Albright & Wilson Inc.  (P.O. Box 26229, Richmond, VA 23260-6229)
   Volume(issue)/page/year: #OPB-3,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3040 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTPTR* Nat

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1500 mg/kg/3D (Continuous)
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   21,160,1993

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1700 mg/L
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   236,933,1987

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 7500 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 8(Suppl
   7),1,1986

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 250 mg/L
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   236,933,1987

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 1600 mg/L
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   236,933,1987

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 2100 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th

其他信息

  • 方法二:由甲醇与三氯化磷反应而得。
  • 上游原料:二氯乙烷 --> 保护剂
  • MOL 文件:868-85-9.mol
  • Sigma Aldrich:868-85-9(sigmaaldrich)
  • 方法一:其制备方法是由甲醇与三氯化磷直接反应制得。3CH 3 OH+PCl 3 →(CH 3 O) 2 POH+2HCl+CH 3 Cl 国内传统工艺是分锅滴加，间歇操作。由于该反应是剧烈的放热反应，反应速度快，瞬间完成，所以操作频繁，劳动强度大，且生产周期长，设备利用率低，生产能力受到限制。在此基础上通过工艺改造实现的连续化生产工艺，总收率达到80%以上(以三氯化磷计)，含量为95％以上。 连续化工艺中的关键是要使三氯化磷与甲醇充分接触，可应用喷射反应器来满足这一要求。连续化工艺合成脱酸所得的亚磷酸二甲酯粗品含量在70％、酸度在10％左右，需进一步用氨中和，在中和过程中需加入保护剂二氯乙烷。中和的副产物氯化铵可经过再处理作肥料用，二氯乙烷可用减压蒸馏的方式加以回收利用。
  • 亚磷酸二甲酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/05/25 L02670 亚磷酸二甲酯, 98+% Dimethyl phosphite, 98+% 500ml 417元 2010/05/25 L02670 亚磷酸二甲酯, 98+% Dimethyl phosphite, 98+% 100ml 283元
  • 下游产品:草甘膦 --> O,O-二甲基-S-(N-甲基氨基甲酰甲基)硫代磷酸酯 --> 亚磷酸酯 --> O,O-二甲基-(2,2,2-三氯-1-羟基乙基)磷酸酯 --> 2-膦酸丁烷-1,2,4-三羧酸 --> 唑啶磷 --> O,O-二甲基磷酰氯 --> O,O-二甲基硫(醇)代磷酸铵
  • Alfa Aesar:亚磷酸二甲酯,98+% Dimethyl phosphite, 98+%(868-85-9)
  • 图谱信息:亚磷酸二甲酯(868-85-9)核磁图( 13 CNMR) 亚磷酸二甲酯(868-85-9)Raman光谱 亚磷酸二甲酯(868-85-9)核磁图( 1 HNMR) 亚磷酸二甲酯(868-85-9)质谱(MS) 亚磷酸二甲酯(868-85-9)红外图谱(IR1)
  • 用途一:亚磷酸二甲酯在农药上可直接用于合成有机磷杀虫剂敌百虫、除草剂草甘膦等，也可用于合成其他含磷中间体，如O，O-二甲基磷酰氯、O，O-二甲基硫(醇)代磷酸铵等。此外，它也是一种重要的有机合成原料，用于有机磷酸型缓蚀剂、塑料助剂、染料添加剂以及纺织品阻燃剂的生产。
  • 敏感性:Moisture Sensitive
  • 用途二:用作润滑油添加剂、胶粘剂和某些有机合成中间体。用于合成杀虫剂氧化乐果、甲基硫环磷和除草剂草甘磷等。
  • MSDS 信息:Dimethyl phosphite(868-85-9).msds

系列性分类

  1. Chemical Synthesis 化学合成
  2. Catalysis and Inorganic Chemistry 催化剂和无机化学
  3. Phosphorus Compounds Catalysis 磷化合物催化剂
  1. Chemical Synthesis 化学合成
  2. Catalysis and Inorganic Chemistry 催化剂和无机化学
  3. Phosphorus Compounds Catalysis 磷化合物催化剂
  4. Phosphine Ligands 膦配体
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Phosphorus Compounds 磷化合物
  5. Organic Phosphates/Phosphites - Phosphorus Compounds

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