2-Methyl-5-Nitrobenzenesulfonyl Chloride 2-甲基-5-硝基苯磺酰氯

CAS 121-02-8 MFCD00051695

化学结构图

121-02-8
SMILES: Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)Cl

化学属性

Mol. FormulaC7H6ClNO4S
Mol. Weight236
Melting Point45-47
Flash Point>110°(230°F)
TSCANo
Boiling Point135-137
Stability对水分敏感

别名和识别编码

Chemical Name2-Methyl-5-Nitrobenzenesulfonyl Chloride
CAS Number121-02-8
Alfabeta NameMETHYLNITROBENZENESULFONYLCHLORIDE 25---
MDL NumberMFCD00051695
Synonym 5-NITRO-O-TOLUENESULFONYL CHLORIDE 4-Nitrotoluen-2-sulfonylchlorid 5-硝基邻甲基苯磺酰氯 Benzenesulfonyl chloride, 2-methyl-5-nitro- 5-Nitro-o-toluenesulfonyl Chloride 5-Nitro-o-toluenesulphonyl chloride 5-nitro-o-toluenesulfonylchlorid 2-METHYL-5-NITROBENZENESULFONYL CHLORIDE 4-Nitrotoluen-2-sulfochlorid 2-methyl-5-nitrobenzene-1-sulphonyl chloride NSC 49752 4-nitrotoluen-2-sulfonylchlorid 2-METHYL-5-NITROPHENYLSULFONYL CHLORIDE 2-Methyl-5-nitrobenzenesulfonic acid chloride 4-nitrotoluen-2-sulfochlorid 5-Nitro-o-toluenesulfonyl chloride 2-Methyl-5-nitrobenzenesulfonyl chloride
EC Number204-444-8
Beilstein Registry Number2697079
Reaxys-RN2697079
Chemical Name Translation2-甲基-5-硝基苯磺酰氯
PubChem Substance ID8457
InChIKeyWPGVQDHXOUAJBW-UHFFFAOYSA-N
Wiswesser Line NotationWSGR B1 ENW
LabNetwork Molecule IDLN00123882
InChIInChI=1S/C7H6ClNO4S/c1-5-2-3-6(9(10)11)4-7(5)14(8,12)13/h2-4H,1H3
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分类

  • Sulfur & Selenium Compounds
  • Intermediates
  • Aromatics
  • {SNA} Building Blocks, Chemical Synthesis, Organic Building Blocks, Sulfonyl Halides, Sulfur Compounds

产品应用

  • Intermediate in the preparation of PDE7 inhibitors and kinase inhibitors.

相关文献及参考

  • Sellitto, I., et al.: Bioorg. Med. Chem. Lett., 20, 387 (2010),
  • Goodman, A., et al.: Bioorg. Med. Chem. Lett., 19, 309 (2009),

安全信息

Warnings MOISTURE SENSITIVE, CORROSIVE
RTECSXT8000000
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Packing GroupII
UN Number
Risk Statements
Storage condition Moisture Sensitive
Hazard Codes C
GHS Symbol
WGK Germany3
Hazard statements
  • H290 May be corrosive to metals 可能腐蚀金属。
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P304+P340
  • P303+P361+P353
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P305+P351+P338
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P304+
  • P305+P351+P338+P310
  • P301+P330+P331+P310
Signal word
Hazard Class8
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7470 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,1072,1986

其他信息

  • MOL 文件:121-02-8.mol
  • Sigma Aldrich:121-02-8(sigmaaldrich)
  • 2-甲基-5-硝基苯磺酰氯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 BTB05516DA 2-甲基-5-硝基苯磺酰氯 2-methyl-5-nitrobenzene-1-sulfonyl chloride 1 GR 405元 2010/05/25 A14760 2-甲基-5-硝基苯磺酰氯, 97% 2-Methyl-5-nitrobenzenesulfonyl chloride, 97% 5g 542元 2010/05/25 A14760 2-甲基-5-硝基苯磺酰氯, 97% 2-Methyl-5-nitrobenzenesulfonyl chloride, 97% 25g 2450元
  • 检测方法:GC
  • MSDS 信息:2-Methyl-5-nitrobenzenesulfonyl chloride(121-02-8).msds
  • Alfa Aesar:2-甲基-5-硝基苯磺酰氯,97% 2-Methyl-5-nitrobenzenesulfonyl chloride, 97%(121-02-8)
  • 敏感性:Moisture Sensitive
  • Acros Organics:2-甲基-5-硝基苯磺酰氯 2-methyl-5-nitrobenzene-1-sulfonyl chloride(121-02-8)

系列性分类


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