6-Chloro-3,4-Dihydro-(2H)-1,2,4-Benzothiadiazine-7-Sulfonamide 1,1-Dioxide 6-氯-7-磺酰胺-3,4-二氢-1,2,4-苯并噻二嗪-1,1-二氧化物

CAS 58-93-5 MFCD00051765

化学结构图

58-93-5
SMILES: NS(=O)(=O)c1cc2c(cc1Cl)NCNS2(=O)=O

化学属性

Mol. FormulaC7H8ClN3O4S2
Mol. Weight297.74
Density1.422
Melting Point266-272°
TSCAYes
Appearance 白色结晶性粉末。溶点273-275℃，溶于丙酮，微溶于醇，不溶于水、氯仿、乙醚，溶于氢氧化钠溶液，但易水解。味微苦。

别名和识别编码

Chemical Name6-Chloro-3,4-Dihydro-(2H)-1,2,4-Benzothiadiazine-7-Sulfonamide 1,1-Dioxide
CAS Number58-93-5
Synonym Hydrodiuretic 6-ch 6-Chlor 6-氯-3, Disalunil Esidrix Maschitt Servithiazid 3,4-dihydro Hypothiazid 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonami Hyp 双氢氯噻嗪 6-氯-7-磺酰胺-3,4-二氢-1,2,4-苯并噻二嗪-1,1-二氧化物 {Chemica 6-Chloro-3,4-dihydro-7-sulphamoyl-1,2,4-ben-zoth-iadi-azine1,1-dioxcide Dichlot Hydrothide Thiaretic 6-Chloro-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benz Su 5879 氢氯噻嗪 Hydril 6-氯-3,4-二氢-2H-1,2,4-苯并噻二嗪-7-磺酰胺-1,1-二氧化物 Direma {uni_ha 氢氯噻嗪, 98% Hidril Fluvin 6-CHLORO-7-SULFAMYL-3,4-DIHYDRO-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE 双氢克尿塞/二氢氯噻 Idrotiazide {h 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide 二氢氯噻 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1,1-dioxide 6-Chloro-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide Hydro-Diuril Ivaugan {C 3,4-Dihydrochlorothiazide 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide Bremil Dihydrochloruri {uni_hambur Acuretic Nefrix Chlorosulthiadil Dyazide {un Aquarius Hypothiazide {haz HCZ Dihydrochlorothiazide Oretic Drenol 6-chloro-3,4-dih Hydro-Aquil Dihydrochlorothiazidum Dihydroxychlorothiazi
MDL NumberMFCD00051765
PubChem Substance ID3639
EC Number200-403-3
Beilstein Registry Number0625101
Merck Number14,4781
Chemical Name Translation6-氯-7-磺酰胺-3,4-二氢-1,2,4-苯并噻二嗪-1,1-二氧化物
Wiswesser Line NotationT66 BSWM EM DHJ HG ISZW
LabNetwork Molecule IDLN00221313
InChIInChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)
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分类

  • Analytical Standards, Analytical/Chromatography, Chromatography, Diuretic, Doping Substances, Forensic and Veterinary Standards, Pharmaceutical Secondary Standards, Pharmaceutical Standards
  • {SNA} Core Bioreagents, Enzyme Inhibitors, Pharmacopoeia, Pharmacopoeia A-Z, Research Essentials, 分析/色谱
  • {uni_hamburg} no charge; sulfur heterocycle; nitrogen heterocycle; carbocycle; aromatic; alicycle; large ring; fused rings; 6ring; 10ring; 1fragment
  • {SNA} Bioactive Small Molecules, Cell Biology, Core Bioreagents, Enzyme Inhibitors, H, Pharmacopoeia, Pharmacopoeia A-Z, Research Essentials

产品应用

  • A carbonic anhydrase inhibitor. Diuretic.

相关文献及参考

  • Piala, J.J., et al.: J. Pharmacol. Exp. Ther., 134, 273 (1961),
  • Deppeler, H.P., et al.: Anal. Profiles Drug Subs., 10, 405 (1981),
  • Merck 14 ,4781
  • Short: III/10a Title: Structure Data of Organic Crystals: C ... C 15 Author: Schudt-Weitz, G.; Strell, I. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: III/10a Year: 1985 ISBN: 3-540-07834-7 ISBN: 978-3-540-07834-0 Internet Resource: DOI:10.1007/b19984 RefComment: XXII, 634 pages. Hardcover Abstract: The volume includes an alphabetical index of all substances and a separate "ring index" with all cyclic compounds.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

WGK Germany2
GHS Symbol
Signal word Warning
Hazard statements
  • H302 Harmful if swallowed 吞食有害
RTECSDK9100000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements
  • S7 Keep container tightly closed 保存在严格密闭容器中；
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S33 Take precautionary measures against static discharges 对静电采取预防措施；
  • S22 Do not breathe dust 不要吸入粉尘；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S24 Avoid contact with skin 避免皮肤接触；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R42/43
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
  • R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard Codes Xn Xi,T,F
Storage condition 2-8°C
UN Number UN 1230 3/PG 2 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 309 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-357,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 590 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 134,273,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes,
   C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
   Volume(issue)/page/year: -,124,1973

{h

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRZKAP Farmatsevtichnii Zhurnal (Kiev).  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR) V.3-    1930-  Volume(issue)/page/year: (5),26,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1470 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes,
   C.D., and L.G. Eltherington, Berkeley, Univ. of California Pre

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 1 gm/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 26,159,1974

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 5 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 500 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-357,1989

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 500 mg/L/48H
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   27,95,1981

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 43 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   10(Suppl 10),1,1987

其他信息

  • 储运特性:库房低温, 通风, 干燥
  • 图谱信息:双氢氯噻嗪(58-93-5)红外图谱(IR1) 双氢氯噻嗪(58-93-5)红外图谱(IR2)
  • Acros Organics:6-Chloro-1,1-dioxo-1,2,3,4-tetrahydro-1lambda~6~,2,4-benzothiadiazine-7-sulfonamide, 97%(58-93-5)
  • 急性毒性:口服- 大鼠 LD50: 2750 毫克/ 公斤; 口服-小鼠 LD50: 1175 毫克/公斤
  • MSDS 信息:Hydrochlorothiazide(58-93-5).msds
  • 毒性分级:中毒
  • 上游原料:3-氯苯胺 --> 4,4'-二氨基苯酰替苯胺
  • Alfa Aesar:氢氯噻嗪,98% Hydrochlorothiazide, 98%(58-93-5)
  • 方法一:由间氯苯胺经氯磺化得到5-氯-2，4-氯磺酰苯胺，再氨反应生成5-氯-2，4-氨磺苯胺，最后用甲醛歪合制得。
  • 双氢氯噻嗪价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 JFD00715EA 双氢氯噻嗪 6-chloro-1,1-dioxo-1,2,3,4-tetrahydro-1lambda~6~,2,4-benzothiadiazine-7-sulfonamide 10 GR 480元 2010/06/21 JFD00715EB 双氢氯噻嗪 6-chloro-1,1-dioxo-1,2,3,4-tetrahydro-1lambda~6~,2,4-benzothiadiazine-7-sulfonamide 25 GR 900元 2010/05/25 B22093 氢氯噻嗪, 98% Hydrochlorothiazide, 98% 25g 955元
  • Hazard Note:Irritant
  • Sigma Aldrich:58-93-5(sigmaaldrich)
  • 可燃性危险特性:可燃; 火场分解有毒氯化氢， 硫氧化物, 氮氧化物气体
  • 灭火剂:水, 二氧化碳, 干粉, 砂土
  • 类别:有毒物质
  • 用途一:该品为噻嗪类中效利尿药的典型代表，在美国1985年药物销售额排第一位。因服用方便，作用中等，且适用于各种水肿，因此是临床上最常因有排钾性不良反应，应用时需补充钾盐。小鼠静永注射LD50为590mg/kg，口服LD50为大于8000mg/kg。
  • MOL 文件:58-93-5.mol

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. H - Bioactive Small Molecules
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. H - Alphabetic
  5. HU - HZ - H
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Pharmaceutical Standards - Chromatography
  5. Pharmaceutical Secondary Standards - Pharmaceutical Standards
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Forensic and Veterinary Standards - Chromatography
  5. Doping Substances - Forensic and Veterinary Standards
  6. Diuretic - Doping Substances

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