BTB1 4-氯-2-硝基-1-(苯基磺酰基)苯
CAS 86030-08-2 MFCD00052250
化学结构图
SMILES: O=[N+]([O-])c1cc(Cl)ccc1S(=O)(=O)c1ccccc1
化学属性
| Mol. Formula | C12H8ClNO4S |
|---|---|
| Mol. Weight | 297.71 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | BTB1 |
|---|---|
| CAS Number | 86030-08-2 |
| Alfabeta Name | BENZENESULFONYLCHLORONITROBENZENE 142------ |
| MDL Number | MFCD00052250 |
| Chemical Name Translation | 4-氯-2-硝基-1-(苯基磺酰基)苯 |
| Formula | C12H8ClNO4S |
| Synonym | BTB1; BTB 1 ; BTB-1. |
| IUPAC Name | 4-chloro-2-nitro-1-(phenylsulfonyl)benzene |
| InChIKey | VZDUQPHKUBZMLW-UHFFFAOYSA-N |
| InChI | InChI=1S/C12H8ClNO4S/c13-9-6-7-12(11(8-9)14(15)16)19(17,18)10-4-2-1-3-5-10/h1-8H |
| Canonical SMILES | O=S(C1=CC=C(Cl)C=C1[N+]([O-])=O)(C2=CC=CC=C2)=O |
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产品应用
- BTB-1 is a novel small molecule inhibitor of the mitotic motor protein Kif18A, which was identified by Catarinella et al. during a highthroughput screen against Kif18A’s MT-stimulated ATPase activity, with an IC50 of 1.7–1.9 M . It is selective within the kinesin subgroup of Kif4, Eg5, MKLP-1, MKLP-2, MPP1, CENP-E and MCAK, and during in vitro motility assays Kif18A’s MT gliding ability was blocked by the addition of BTB-1 in a reversible manner. BTB-1 was found to be ATP competitive and MT uncompetitive, only inhibiting the ATPase activity of the MT-bound motor protein. BTB-1 could serve as a valuable tool in disentangling the nature of Kif18A’s double functionality within mitosis and assessing for potential therapeutic utilities.
相关文献及参考
- [2]. Braun J, et al. Synthesis and biological evaluation of optimized inhibitors of the mitotic kinesin Kif18A. ACS Chem Biol. 2015 Feb 20;10(2):554-60.
- [1]. Catarinella M, et al. BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A. Angew Chem Int Ed Engl. 2009;48(48):9072-6.
- [1]. Catarinella M, et al. BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A. Angew Chem Int Ed Engl. 2009;48(48):9072-6.
- [2]. Braun J, et al. Synthesis and biological evaluation of optimized inhibitors of the mitotic kinesin Kif18A. ACS Chem Biol. 2015 Feb 20;10(2):554-60.
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