Dimenhydrinate 茶苯海明

CAS 523-87-5 MFCD00054265

化学结构图

523-87-5
SMILES: CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O

化学属性

Mol. FormulaC17H21NO · C7H7ClN4O2
Mol. Weight469.96
Melting Point102-107°
Solubility略溶于水 (0.1-1 G/100 ML AT 22 ºC)
TSCAYes

别名和识别编码

Chemical NameDimenhydrinate
CAS Number523-87-5
MDL NumberMFCD00054265
Synonym N-(2-Diphenylmethoxyethyl)-N,N-dimethylammonium 8-chlorotheophyllinate; 2-(Benzhydryloxy)-N,N-dimethylethylamine 8-chlorotheophyllinate; 8-Chloro-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione compound with 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1) benzhydryl-beta-dimethylaminoethylether8-chlorotheophylline diamarin 6-dione,8-chloro-3,7-dihydro-1,3-dimethyl-1h-pyrine-compdwith2-(diphenyl 捉迷明 2-(benzhydryloxy)-n,n-dimethylethylamine 8-chlorotheophyllinate 8-chloro-3,7-dihydro-1,3-dimethyl-1h-purine-2,6-dione compound with 2-(diphenylmethoxy)-n,n-dimethylethanamine (1:1) andramine 乘晕宁 antemin O-Benzhydryldimethylaminoethanol 8-chlorotheophyllinate {Chemicalb 2-(benzhydryloxy)-n,n-dimethylethylaminecompd.with8-chlorotheophylline Amosyt N-[2-DIPHENYLMETHOXYETHYL]-N,N-DIMETHYLAMMONIUM 8-CHLORO-THEOPHYLLINATE anautine beta-dimethylaminoethylbenzhydrylether1,3-dimethyl-8-chloroxanthine Dimenhydrinate 茶苯海明 N-(2-Diphenylmethoxyethyl)-N,N-dimethylammonium 8-chlorotheophyllinate Andramine aviomarin 8-chlorotheophylline,compd.with2-(diphenylmethoxy)-n,n-dimethylethylamine 茶苯海明(晕车药) 8-Chlorotheophylline, compd. with Benzhydryl-beta-dimethylaminoethylether 8-chlorotheophylline amosyt 晕海宁 DIMENHYDRINATE 二甲基氢 曲拉明 2-(Benzhydryloxy)-N,N-dimethylethylamine compd. with 8-chlorotheophylline chloranautine 6-dione,8-chloro-3,7-dihydro-1,3-dimethyl-1h-purine-compd.with2-(dipheny Chloranautine 1,3- 2-(diphenylmethoxy)-n,n-dimethylethylamine8-chlorotheoph
EC Number208-350-8
Merck Number14,3207
Chemical Name Translation茶苯海明
Wiswesser Line NotationT56 BM DN FNVNVJ CG F H &622
LabNetwork Molecule IDLN00222677
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分类

  • {SNA} Antagonists, Bioactive Small Molecule Alphabetical Index, DIG-DY, Histaminergics, Neuroscience, Neurotransmission, Neurotransm
  • {SNA} Antagonists, Histaminergics, Neuroscience, Neurotransmission, Neurotransmitters, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Antagonists, Bioactive Small Molecule Alphabetical Index, DIG-DY, Histaminergics, Neuroscience, Ne
  • {SNA} Antagonists, Cell Signaling and Neuroscience, Histaminergics, Neuroscience, Neurotransmission, Neurotransmitters, 细胞生物学

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H302 Harmful if swallowed 吞食有害
RTECSXH5082000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DU

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1320 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,346,1982

TYPE OF TEST

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 11400 ug/kg
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
REFERENCE :
   AJPSAO American Journal of Psychiatry.  (American Psychiatric Assoc.,
   Circulation Dept., 1400 K St., NW, Washington, DC 20005)  V.78-    1921-
   Volume(issue)/page/year: 128,1012,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 203 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,346,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - infant
DOSE/DURATION           : 114 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - coma
   Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
   JTCTDW Journal of Toxicology, Clinical Toxicology.  (Marcel Dekker, 270
   Madison Ave., New York, NY 10016)  V.19-    1982-  Volume(issue)/page/year:
   29,527,1991

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 333 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 9(Suppl
   9),1,1987

其他信息

  • 用途二:适用于晕动症、妊娠、放射治疗、手术后等引起的恶心、呕吐、眩晕等。
  • 用途一:晕车药
  • Sigma Aldrich:523-87-5(sigmaaldrich)
  • MSDS 信息:N-(2-Diphenylmethoxyethyl)-N,N-dimethylammonium 8-chlorotheophyllinate(523-87-5).msds
  • MOL 文件:523-87-5.mol

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurotransmission - Neuroscience
  6. Neurotransmitters - Neurotransmission
  7. Histaminergics - Neurotransmitters
  8. Antagonists - Histaminergics
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Histamine Receptor  (组胺受体)

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