N-Ethyl-3-Hydroxy-N,N-Dimethylbenzenaminium Chloride N-乙基-3-羟基-N,N-二甲基苯胺氯化物

CAS 116-38-1 MFCD00055064

化学结构图

116-38-1
SMILES: CC[N+](C)(C)c1cccc(O)c1.[Cl-]

化学属性

Mol. FormulaC10H16NO.Cl
Mol. Weight201.72

别名和识别编码

Chemical NameN-Ethyl-3-Hydroxy-N,N-Dimethylbenzenaminium Chloride
CAS Number116-38-1
Synonym Ammonium, dimethylethyl(m-hydroxyphenyl)-, chloride Antirex Benzenaminium, N-ethyl-3-hydroxy-N,N-dimethyl-, chloride Bromide, Edrophonium Chloride, Edrophonium Dimethylethyl(m-hydroxyphenyl)ammonium chloride EDROPHONIUM CHLORIDE ETHYL[M-HYDROXYPHENYL]-DIMETHYLAMMONIUM CHLORIDE Edrophonium Edrophonium Bromide Edrophonium Chloride Edrophonium chloride Edroponium Enlon Ethyl(m-hydroxyphenyl)dimethylammonium Chloride Ethyl(m-hydroxyphenyl)dimethylammonium chloride N-Ethyl-3-hydroxy-N,N-dimethyl-benzenaminium Chloride N-Ethyl-3-hydroxy-N,N-dimethylanilinium chloride N-ethyl-3-hydroxy-N,N-dimethylanilinium chloride N-乙基-3-羟基-N,N-二甲基苯胺氯化物 Reversol Tensilon Tensilon Chloride Tensilon chloride antirex {Che
MDL NumberMFCD00055064
PubChem Substance ID8307
EC Number204-138-4
Chemical Name TranslationN-乙基-3-羟基-N,N-二甲基苯胺氯化物
Wiswesser Line NotationQR CK2&1&1 &G
LabNetwork Molecule IDLN00188969
InChIInChI=1S/C10H15NO.ClH/c1-4-11(2,3)9-6-5-7-10(12)8-9;/h5-8H,4H2,1-3H3;1H
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分类

  • Inhibitors
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {SNA} A to C, Acetylcholinesterase, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cholinesterase, acetyl, E, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Neuroscience, Neurotransmission, Neurotransmitter Metabolism, Valeant

产品应用

  • A reversible Acetylcholinesterase inhibitor.

相关文献及参考

  • Lyon, R., et al.: J. Pharm. Sci., 95, 1549 (2006),
  • Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009),
  • Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),

安全信息

WGK Germany3
RTECSBQ5870000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 10,327,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 52 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - muscle weakness
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 123,121,1958

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 115,185,1955

其他信息

  • MOL 文件:116-38-1.mol
  • Sigma Aldrich:116-38-1(sigmaaldrich)

系列性分类


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