Fluspirilene 氟斯必灵
CAS 1841-19-6 MFCD00055137
化学结构图
SMILES: O=C1NCN(c2ccccc2)C12CCN(CCCC(c1ccc(F)cc1)c1ccc(F)cc1)CC2
化学属性
| Mol. Formula | C29H31F2N3O |
|---|---|
| Mol. Weight | 475.57 |
别名和识别编码
| Chemical Name | Fluspirilene |
|---|---|
| CAS Number | 1841-19-6 |
| Synonym | 1-Phenyl-4-oxo-8-(4,4-bis(4-fluorophenyl)butyl)-1,3,8-triazaspiro(4,5)decane 8-(4,4-Bis(p-fluorophenyl)butyl)-1-phenyl-1,3,8-triazaspiro(4,5)decan-4-one 8-[4,4-Bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one 8-[4,4-bis(p-Fluorophenyl)butyl]-1-phenyl-1,3,8-triazino[4.5]decan-4-one 8-[4,4-bis(p-Fluorophenyl)butyl]-1-phenyl-1,3,8-triazino[4.5]decan-4-one R 6218 Fluspirilen Fluspirilene Fluspiriline IMAP Imap McN-JR 6218 McN-JR-6218 R 6218 Redeptin |
| MDL Number | MFCD00055137 |
| PubChem Substance ID | 3396 |
| EC Number | 217-418-6 |
| Chemical Name Translation | 氟斯必灵 |
| Wiswesser Line Notation | T6N DXTJ A3YR DF&R DF& D-& CT5MVXN EHJ DR |
| Beilstein Registry Number | 0633853 |
| LabNetwork Molecule ID | LN01343719 |
| InChI | InChI=1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,8-15,27H,4,7,16-21H2,(H,32,35) |
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分类
- {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Calcium Channel Modulators, Dopaminargics - Antagonists, Dopaminergics, F, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Inhibitors and Activators, Ion Channels, Johnson & Johnson, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Voltage-gated Ion Channels, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 蛋白质及衍生物
- Heterocycles
- {SNA} Antagonists, Approved Therapeutics/Drug Candidates,
产品应用
- Fluspirilene is a diphenylbutylpiperidine antipsychotic drug, used for the treatment of schizophrenia.
相关文献及参考
- Janssen, P.A.J., et al.: Arzneim.-Forsch., 20, 1689 (1970),
- Cox, D., et al.: J. Cardiovasc. Pharmacol., 21, 595 (1993),
- Toenjes, K., et al.: Antimicrob. Agents Chemother., 49, 963 (2005),
安全信息
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - man DOSE/DURATION : 183 ug/kg TOXIC EFFECTS : Skin and Appendages - corrosive (after topical exposure) REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 1,523,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >146 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1689,1970
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >37 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1689,1970
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : >80 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1689,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intr
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