Albuterol sulfate [USAN:USP] 硫酸沙丁胺醇

CAS 51022-70-9 MFCD00055200

化学结构图

51022-70-9
SMILES: CC(C)(C)NCC(O)C1C=CC(O)=C(CO)C=1.OS(O)(=O)=O

化学属性

Mol. FormulaC13H21NO3.1/2H2O4S
Mol. Weight288.35
TSCANo
Density1.436
Melting Point180°C

别名和识别编码

Chemical NameAlbuterol sulfate [USAN:USP]
Synonym 疑甲叔丁肾上腺素 硫酸舒喘灵 Salbutamol sulfate Albuterol sulfate α1-[(叔丁基氨基)甲基]-4-羟基-1,3-苯二甲醇 半硫酸盐 沙丁胺醇 半硫酸盐 硫酸舒喘灵 Salbutamol hemisulfate salt Salbutamol hemisulfate 阿布叔醇 硫酸沙丁胺醇 alpha-[(tert-Butylamino)methyl]-4-hydroxy-m-xylene-alpha,alpha-diol; Albuterol 沙丁胺醇硫酸盐 1-(4-Hydroxy-3-hydroxymethylphenyl)-2-(tert-butylamino)ethanol sulfate
MDL NumberMFCD00055200
CAS Number51022-70-9
EC Number256-916-8
PubChem Substance ID24870399
Chemical Name Translation硫酸沙丁胺醇
InChIKeyBNPSSFBOAGDEEL-UHFFFAOYSA-N
Wiswesser Line NotationQ1R BQ EYQ1MX1&1&1 2 &..H2.S-O4
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分类

  • {SNA} Adrenergics, Adrenergics - Agonists, Agonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies,
  • Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Secondary Standards, Pharmaceutical Standards
  • {SA} Alphabetic, Analytical Standards, Analytical/Chromatography, Antibiotics, Chemical Structure, Chromatography, Clinical Standards, Others, S, SA - SM

产品应用

  • β2-肾上腺素能受体激动剂。 其机制为激活腺苷环化酶，促进环磷腺苷生成。

相关文献及参考

  • Merck: 14,216

安全信息

WGK Germany2
RTECSCZ6430100
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
Hazard Codes Xn 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 13300 mg/kg/95W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Reproductive - Tumorigenic effects - ovarian tumors
   Tumorigenic - tumor types after systemic administration not seen
   spontaneously
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 12,13,1993

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 48700 ug/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 2,128,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 295 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 2,128,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 2,128,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1950 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(is

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 gm/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 22,191,1981

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Approved Therapeutics/Drug Candidates - Cell Signaling and Neuroscience
  5. GlaxoSmithKline - Approved Therapeutics/Drug Candidates
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Pharmaceutical Standards - Chromatography
  5. Pharmaceutical Secondary Standards - Pharmaceutical Standards
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. S - Alphabetic
  5. SA - SM - S
  1. Functional Group 官能团索引
  2. sulfuric acid

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