Ketoprofen 酮洛芬

CAS 22071-15-4 MFCD00055790

化学结构图

22071-15-4
SMILES: CC(C(O)=O)C1C=CC=C(C=1)C(=O)C1C=CC=CC=1

化学属性

Mol. FormulaC16H14O3
Mol. Weight254
Melting Point94.0 to 97.0 deg-C

别名和识别编码

Chemical NameKetoprofen
CAS Number22071-15-4
Alfabeta NameKETOPROFEN
MDL NumberMFCD00055790
Synonym 2-(3-Benzoylphenyl)propionic acid Oruvail 2-(3-苯甲酰苯基)丙酸 2-(3-苯甲酰苯基)丙酸 酮洛芬 2-(m-Benzoylphenyl)propionic acid Orudis Ketoprofen Ketoprofene Benzeneacetic acid, 3-benzoyl-alpha-methyl- Profenid RP 19583 Capisten Ketoprophene 3-Benzoyl-alpha-methylbenzeneacetic acid Epatec RU 4733 酮洛芬 m-Benzoylhydratropic acid Acide (benzoyl-3-phenyl)-2-propionique 19583 RP Aneol Alrheumun 3-Benzoylhydratropic acid
PubChem Substance ID87571970
EC Number244-759-8
Reaxys-RN2216071
Merck Number5305
Chemical Name Translation酮洛芬
Beilstein Registry Number2216071
Wiswesser Line NotationQVY1&R CVR
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分类

  • A to C, Anti-inflam
  • {SNA} Analytical Standards, Pharmacopeia & Metrological Institutes Standards, USP Standards, USP Standards I - K, 分析/色谱
  • {SNA} Application Index, Cell Signaling Enzymes, Core Bioreagents, Cyclooxygenase (COX) Enzymes, Cyclooxygenase Inhibitors, Enzyme Inhibitors, Pharmacopoeia,

相关文献及参考

  • Merck 14 ,5305

安全信息

Warnings IRRITANT
WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P310+P330
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes T
RTECSUE7570000
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Safety Statements
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Hazard Class6.1
UN Number 2811
Packing GroupIII
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Rectal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 84 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - ulceration or bleeding from small intestine
   Gastrointestinal - peritonitis
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 6,209,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 360 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PJPPAA Polish Journal of Pharmacology and Pharmacy.  (ARS Polona, POB 1001,
   00-068 Warsaw 1, Poland) V.25-    1973-  Volume(issue)/page/year:
   38,107,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JNPHAG Journal de Pharmacologie.  (SPPIF, B.P.22, F-41353 Vineuil, France)
   V.1-    1970-  Volume(issue)/page/year: 2,259,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 714 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
REFERENCE :
   JCPCBR Journal of Clinical Pharmacology.  (Hall Assoc., PO Box 482,
   Stamford, CT 06904) V.13-    1973-  Volume(issue)/page/year: 24,486,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 393,123,1997

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 mg/kg
SEX/DURATION            : female 21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 27,117,1984

系列性分类


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