Tetrac 3,3',5,5'-四碘甲腺-乙酸

CAS 67-30-1 MFCD00055932

化学结构图

67-30-1
SMILES: O=C(O)Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1

化学属性

Mol. FormulaC14H8I4O4
Mol. Weight747.83
Melting Point219-220 °C
Boiling Point544.8±50.0 °C at 760 mmHg

别名和识别编码

Chemical NameTetrac
CAS Number67-30-1
Synonym Tetrac {LY} Tetrac {} {LY} Tetrac {} {} {LY} Tetrac {} {} {} {LY} Tetrac {} {} {} {} {LY} Tetrac {} {} {} {} {} {LY} Tetrac {} {} {} {} {} {} {LY} Tetrac {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {LY} Tetrac {} {} {} {} {} {} {} {} {LY} Tetrac {} {} {} {} {} {} {} {} {} {LY} Tetrac {} {} {} {} {} {} {} {} {} {} {LY} Tetrac {} {} {} {} {} {} {} {} {} {} {} {LY} Tetrac {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Tetrac {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Tetrac {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Tetrac {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Tetrac {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Tetrac {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Tetrac {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00055932
PubChem Substance ID24900169
EC Number200-649-1
Chemical Name Translation3,3',5,5'-四碘甲腺-乙酸
Reaxys-RN2173215
LabNetwork Molecule IDLN01300112
Canonical SMILESO=C(O)CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1
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分类

  • Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones,
  • {SNA} Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Pituitary Hormones, Thyroid Stimulating Hormone, 细胞生物学
  • {SNA} Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Pituitary Hormones, Thyroid Stimulating Hormone
  • {SNA} Bioactive Small Molecule Alphabetical Index, Cytokines, Growth Factors and Hormones, Hormones, Pituitary Hormones, T, Thyroid Stimulating Hormone, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

产品应用

  • Thyroid hormone analogue

相关文献及参考

  • [2]. Davis PJ, et, al. Nongenomic Actions of Thyroid Hormone: the Integrin Component. Physiol Rev. 2020 Jun 25.
  • [3]. Chin YT, et, al. Tetrac and NDAT Induce Anti-proliferation via Integrin αvβ3 in Colorectal Cancers With Different K-RAS Status. Front Endocrinol (Lausanne). 2019 Mar 12; 10:130.
  • [4]. Ashur-Fabian O, et, al. Tetrac Delayed the Onset of Ocular Melanoma in an Orthotopic Mouse Model. Front Endocrinol (Lausanne). 2019 Jan 8; 9:775.
  • [5]. Rajabi M, et, al. Synthesis of new analogs of tetraiodothyroacetic acid (tetrac) as novel angiogenesis inhibitors for treatment of cancer. Bioorg Med Chem Lett. 2018 Apr 15;28(7):1223-1227.
  • Horst, C., et al.: Biochem. J., 261, 945
  • [1]. Schmohl KA, et, al. Tetrac as an anti-angiogenic agent in cancer. Endocr Relat Cancer. 2019 Jun 1; 26(6):R287-R304.
  • [1]. Schmohl KA, et, al. Tetrac as an anti-angiogenic agent in cancer. Endocr Relat Cancer. 2019 Jun 1; 26(6):R287-R304.
  • [2]. D

安全信息

RTECSCY1585800
WGK Germany3
GHS Symbol
Precautionary statements
  • P301+P310+P330
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P405 Store locked up. 上锁保管。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P301+P310
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
Hazard statements
  • H300 Fatal if swallowed 吞食致命
Hazard Codes T+
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Signal word Danger
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R28 Very toxic if swallowed 吞咽极毒
Storage condition -20°C, protect from light {LY} -20°C, protect from light <0°C {} {LY} -20°C, protect from light {} {} {LY} -20°C, protect from light {} {} {} {LY} -20°C, protect from light {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Hazard Class6.1
UN Number 2811
Packing GroupI

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Pituitary Hormones - Hormones
  7. Thyroid Stimulating Hormone - Pituitary Hormones
  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. Integrin  (整合素)
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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