Megestrol Acetate 醋酸孕甾酮
CAS 595-33-5 MFCD00056470
化学结构图
SMILES: CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C
化学属性
| Mol. Formula | C24H32O4 |
|---|---|
| Mol. Weight | 385 |
| Appearance | White to off-white solid powder 白色或微黄色结晶性粉末（甲醇），无嗅无味。熔点214-216℃ 。溶于丙酮，微溶于乙醇、乙醚，不溶于水。 |
| Melting Point | 214 |
| Refractive index | 11 ° (C=2, CHCl3) |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | Megestrol Acetate |
|---|---|
| Synonym | 17α-羟基-6-甲基-6-去氢孕酮 17-乙酸酯 17-alpha-Acetoxy-6-dehydro-6-methylprogesterone 17-alpha-Acetoxy-6-methyl-4,6-pregnadiene-3,20-dione 17-hydroxy-6-methylpregna-4,6-diene-3,20-dione acet 17ALPHA-HYDROXY-6-METHYL-4,6-PRE 17alpha-acetoxy-6-methylpregna-4,6-diene-3,20-d 17α-Acetoxy-6-methyl-4,6-pregnadiene-3,20-dione 17α-乙酰氧基-6-甲基孕甾-4,6-二烯-3,20-二酮 17α-羟基-6-甲基-6-去氢孕酮 17-乙酸酯 17α-羟基-6-甲基孕甾-4,6-二烯-3,20-二酮 17-乙酸酯 甲地孕酮 17-乙酸酯 4,6-PREGNADIEN-6-METHYL-17-OL-3,20-DIONE ACETATE 6-Dehydro-6-methyl-17alpha-acetoxyprogesterone 6-dehydro-6-methyl-17-alpha-acetoxyprogesterone 6-dien 6-methyl-17-alpha-hydroxy-delta(sup6)-progesteroneacetate 6-甲基孕甾-4,6-二烯-17α-醇-3,20-二酮-17-醋酸酯 BDH 1298; BDH1298; BDH-1298; Megace; Ovaban; Pallace. Maygace; Megestil; Niagestin. DMAP MEGESTROL |
| MDL Number | MFCD00056470 |
| PubChem Substance ID | 87560201 |
| Beilstein Registry Number | 1917291 |
| CAS Number | 595-33-5 |
| EC Number | 209-864-5 |
| Chemical Name Translation | 醋酸孕甾酮 |
| Reaxys-RN | 1917291 |
| Merck Number | 5805 |
| Wiswesser Line Notation | L E5 B666 OV KU MUTJ A1 E1 FV1 FOV1 L1 |
| LabNetwork Molecule ID | LN01299023 |
| Formula | C24H32O4 |
| IUPAC Name | (8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate |
| InChIKey | RQZAXGRLVPAYTJ-GQFGMJRRSA-N |
| InChI | InChI=1S/C24H32O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h12-13,18-20H,6-11H2,1-5H3/t18-,19+,20+,22-,23+,24+/m1/s1 |
| Canonical SMILES | CC(O[C@]1(C(C)=O)CC[C@@]2([H])[C@]3([H])C=C(C)C4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O)=O |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} Analytical Standards, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards L - M, 分析/色谱
- {SNA} Additional Standards, Analytical Standards, Chemical Structure, Chromatography, Drugs & Metabolites, Drugs of Abuse, Forensic and Veterinary Standards, Neat Compounds, Steroid, 分析/色谱
- {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Chemical Structure, Chromatography, Drugs & Metabolites, Drugs of Abuse,
- {SNA} Analytical Standards, Pharmacopeia Metrological Institutes Standards, USP Standards,
产品应用
- Megestrol acetate is the acetate ester of megestrol, a synthetic derivative of the naturally occurring female sex hormone progesterone, with progestogenic, antiestrogenic, and antineoplastic activities. Mimicking the action of progesterone, megestrol binds to and activates nuclear progesterone receptors (PRs) in the reproductive system and pituitary; ligand-receptor complexes are translocated to the nucleus where they bind to progesterone response elements (PREs) located on target genes.
相关文献及参考
- Merck 14 ,5805
安全信息
GHS Symbol
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P308+P313
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H351 Suspected of causing cancer 怀疑致癌
- H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
- S22 Do not breathe dust 不要吸入粉尘；
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
- R48 Danger of serious damage to health by prolonged exposure 长期接触有严重损害健康的危险
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 256 mg/kg/7Y-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Endocrine - diabetes mellitus REFERENCE : JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 3,167,1977
TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 182 mg/kg/2Y-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors REFERENCE : JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 219,1601,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 56 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00931
TYPE OF TEST : DNA adduct TEST SYSTEM : Rodent - rat Liver DOSE/DURATION : 30 umol/L REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 16,1483,1995
TYPE OF TEST : Unscheduled DNA synthesis ROUTE OF EXPOSURE : Subcutaneous TEST SYSTEM : Rodent - mouse DOSE/DURATION : 200 mg/kg REFERENCE : JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939- Volume(issue)/page/year: 60,167,1974
TYPE OF TEST : DNA adduct TEST SYSTEM : Human Liver DOSE/DURATION : 20 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 395,179,1997
TYPE OF TEST : DNA inhibition ROUTE OF EXPOSURE : Subcutaneous TEST SYSTEM : Rodent - mouse DOSE/DURATION : 200 mg/kg REFERENCE : JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939- Volume(issue)/page/year: 60,167,1974
TYPE OF TEST : DNA adduct ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - rat DOSE/DURATION : 100 mg/kg REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 16,1483,1995
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE : 16800 ug/kg SEX/DURATION : female 21 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 5,331,1963
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE : 625 ug/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles) REFERENCE : ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 73,17,1963
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Primate - monkey DOSE : 100 ug/kg SEX/DURATION : female 5 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 25,99,1971
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE : 15 mg/kg SEX/DURATION : female 30 day(s) pre-mating TOXIC EFFECTS : Re
其他信息
- MOL 文件:595-33-5.mol
- Sigma Aldrich:595-33-5(sigmaaldrich)
- TCI Shanghai:甲地孕酮乙酸酯 Megestrol Acetate,>;96.0%(LC)(595-33-5)
- 用途一:安宫黄体酮（甲孕酮）的中间体。
- 下游产品:6Β-甲基孕甾-4-烯-17Α-醇-3,20-二酮-17-醋酸酯
- 醋酸甲地孕酮价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 M1949 醋酸甲地孕酮 Megestrol Acetate 5G 1700元 2011/04/16 M1949 醋酸甲地孕酮 Megestrol Acetate 1G 560元
- 方法一:可用16,17α-环氧黄体酮经溴化氢开环及镍催化还原脱溴，生成17α-羟基黄体酮，再经乙酰化及酸水解生成17α-乙酰氧基黄体酮，然后以原甲酸三乙酯醚化及Vilsmeier反应得3-乙氧基-6-甲酰基-17α-乙酰氧基孕甾-2,5-二烯-20-酮，最后以硼氢化钾还原，酸水解、脱水并转位制得该品。
- 上游原料:硼氢化钾 --> 16,17-环氧黄体酮 --> 羟孕酮
- 醋酸甲地孕酮价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M1949 醋酸甲地孕酮 Megestrol Acetate 5G 989元 2014/06/02 M1949 醋酸甲地孕酮 Megestrol Acetate 1G 332元
京ICP备2020036287号