HT-2 Toxin HT-2 毒素
CAS 26934-87-2 MFCD00056784
化学结构图
SMILES: CC12[C@H](O)[C@@H](O)C(O[C@@H]3C=C(C)[C@H](C[C@]13COC(C)=O)OC(=O)CC(C)C)C12CO1
化学属性
| Mol. Formula | C22 |
|---|---|
| Mol. Weight | 424 |
别名和识别编码
| Chemical Name | HT-2 Toxin |
|---|---|
| CAS Number | 26934-87-2 |
| Synonym | 15-Acetoxy-3α,4β-dihydroxy-8α-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene 12,13-Epoxytrichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol 15-acetate ######## |
| MDL Number | MFCD00056784 |
| PubChem Substance ID | 24900196 |
| Chemical Name Translation | HT-2 毒素 |
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分类
- Heterocycles
- Mutagenesis Research Chemicals
- Pharmaceuticals
- Intermediates & Fine Chemicals
- {SNA} Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Mold, Nitric Oxide and Cell Stress, Oxidative Stress Proteins and Reagents, Toxins and Venoms
产品应用
- HT-2 Toxin is a trichothecene group mycotoxin. HT-2 Toxin is the 4-hydroxy analogue of T-2 Toxin (T002980) which has been shown to induce DNA damage and cell death on prolonged administration.
相关文献及参考
- Weidner, M. et al.: J. Agric. Food Chem., 60, 5676 (2012); Choi, H. et al.: Toxicol. Appl. Pharmacol., 240, 46 (2009); Amuzie, C. et al.: Toxicol. Sci., 113, 412 (2010);
安全信息
GHS Symbol
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P302+P350
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H330 Fatal if inhaled 吸入致命
- H310 Fatal in contact with skin 皮肤接触致命
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H300 Fatal if swallowed 吞食致命
- H319 Causes serious eye irritation 严重刺激眼睛
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 6,191,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6700 ug/kg TOXIC EFFECTS : Details of toxi
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 26,923,1988
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intracerebral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 52 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - fluid intake Behavioral - ataxia REFERENCE : TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 26,923,1988
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 500 ug/kg TOXIC EFFECTS : Blood - hemorrhage REFERENCE : DFSCDX Developments in Food Science. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year: 4,135,1983
- S22 Do not breathe dust 不要吸入粉尘；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
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