4-Amino-N-(1-Phenyl-1H-Pyrazol-5-Yl)Benzenesulfonamide 4-氨基-N-(1-苯基-1H-吡唑-5-基)苯磺酰胺

CAS 526-08-9 MFCD00057226

化学结构图

526-08-9
SMILES: Nc1ccc(S(=O)(=O)Nc2ccnn2-c2ccccc2)cc1

化学属性

Mol. FormulaC15H14N4O2S
Mol. Weight314
Density1.422
Melting Point156-158

别名和识别编码

Chemical Name4-Amino-N-(1-Phenyl-1H-Pyrazol-5-Yl)Benzenesulfonamide
Synonym 1-Phenyl-5-sulfanilamidopyrazole 3-(p-Aminobenzenesulfonamido)-2-phenylpyrazole 4-Amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide 5-Sulfanilamido-1-phenylpyrazole Depocid Depotsulfonamide Eftolon Firmazolo Inamil Isarol Merian Microtan pirazolo N'-(1-Phenylpyrazol-5-yl)sulfanilamide N(sup 1)-(1-Phenylpyrazol-5-yl)sulfanilamide Orisul Orisulf Paidazolo Plisulfan Raziosulfa SP SPP Sulfabid Sulfafenazolo Sulfanilamide, N(sup 1)-(1-phenylpyrazol-5-yl)- Sulfaphenazole Sulfaphenazon Sulfaphenylpipazol Sulfaphenylpyrazole Sulphenazole
MDL NumberMFCD00057226
PubChem Substance ID5335
CAS Number526-08-9
EC Number208-384-3
Beilstein Registry Number0308518
Alfabeta NameSULFAPHENAZOLE
Chemical Name Translation4-氨基-N-(1-苯基-1H-吡唑-5-基)苯磺酰胺
Wiswesser Line NotationT5NNJ BR& CMSWR DZ
LabNetwork Molecule IDLN00181417
InChIInChI=1S/C15H14N4O2S/c16-12-6-8-14(9-7-12)22(20,21)18-15-10-11-17-19(15)13-4-2-1-3-5-13/h1-11,18H,16H2
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分类

  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Drug and Xenobiotic Metabolism, Multi-Drug Resistance and Drug Metabolism, S, Substrates, Inducers,
  • {SA} A to C, Application Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience, Cytochrome P450 TB enzymes, Drug and Xenobiotic Metabolism, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Inhibitors, Multi-Drug Resistance and Drug Metabolism, S, Substrates, Inducers, Inhibitors, Xenobiotics and Drug Metabolism

相关文献及参考

  • Viswanathan, S., et al. J. Am. Coll. Nutr. 22 , 502-510, (2003)
  • Schmidt, P., and Druery, J. Helv. Chim. Acta 41 , 306, (1958)
  • Giannarelli C., et al., Effect of sulfaphenazole on tissue plasminogen activator release in normotensive subjects and hypertensive patients Circulation 119 , 1625-1633, (2009)
  • Merck 14 ,8935

安全信息

WGK Germany2
RTECSDA9520000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Signal word Warning
GHS Symbol
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
Warnings IRRITANT
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 950 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,387,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 525 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIR

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3016 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MIMEAO Minerva Medica.  (Edizioni Minerva Medica, Casella Postale 491,
   I-10126 Turin, Italy) V.1-    1909-  Volume(issue)/page/year: 52,1789,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,387,19

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 440 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,387,1982

系列性分类


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