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分类

• Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience, Muscle Relaxants, Neurobiology, Neuroscience, Pharmacologicals, Schering Plough
• {SNA} Analytical Standards, Analytical/
• {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards C - D,
• {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience, Muscle Relaxants, Neurobiology, Neuroscience, Pharmacologicals, Schering Plough

产品应用

• Muscle relaxant (skeletal).

相关文献及参考

• Musso, D., et al.: J. Med. Chem. 46, 399 (2003)
• Barnett, A. , Goldstein, J., Fiedler, E., Etonitazine-induced rigidity and its antagonism by centrally acting muscle relaxants. Eur. J. Pharmacol. 30 , 23, (1975) 摘要
• Merck 14 ,1842

安全信息

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1800 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting re

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 238,92,1960

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - altered sleep time (including change in righting reflex)
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 127,66,1959

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1320 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - altered sleep time (including change in righting reflex)
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 277 gm/kg
SEX/DURATION            : male 15 week(s) pre-mating  - 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   24,132,1995

其他信息

• MSDS 信息:Carisoprodol(78-44-4).msds
• Sigma Aldrich:78-44-4(sigmaaldrich)
• MOL 文件:78-44-4.mol