2-Hydroxy-3-(2-Methoxyphenoxy)Propyl Carbamate 2-羟基-3-(2-甲氧基苯氧基)丙基 氨基甲酸酯

CAS 532-03-6 MFCD00057662

化学结构图

532-03-6
SMILES: COc1ccccc1OCC(O)COC(N)=O

化学属性

Mol. FormulaC11H15NO5
Mol. Weight241
Appearance 白色或微灰白色结晶性粉末；无臭或微有异臭。在乙醇、氯仿中易溶，在乙醚中微溶，在水中略溶。2%水溶液的pH值为5.0～7.0。应避光，密闭容器中贮存。其性质稳定。 熔点 77-81℃，沸点 215℃，水溶性 5g/100ml(25℃)
SolubilitySoluble in DMSO, Methanol and Water (sparingly)
Melting Point94-98

别名和识别编码

Chemical Name2-Hydroxy-3-(2-Methoxyphenoxy)Propyl Carbamate
CAS Number532-03-6
Synonym 1,2-Propanediol,3-(2-methoxyphenoxy)-,1-carbamate 1-氨基甲酸3-(2-甲氧苯氧)-1,2-丙二醇酯 2-Hydroxy-3-(o-methoxyphenoxy)propyl carbamate 3-(2-Methoxyphenoxy)-1-glyceryl carbamate 3-(o-methoxyphenoxy)-1,2-propanediol1-carbamate AHR 85 Avetil Carbamic Acid 2-Hydroxy-3-(2-methoxyphenoxy)propyl Ester Carbamic acid, 2-hydroxy-3-(o-methoxyphenoxy)propyl ester Glycerylguaiacolate carbamate Glycerylguajacol-carbamat Guaiacol glyceryl ether carbamate Guaiacol glyceryl ether carbamate; Glycerylguaiacolate carbamate LABOTEST-BB LT00134642 Neuraxin Reflexyn Relestrid Robaxin Robaxine 甲氧卡巴莫 甲氧卡巴莫 美索巴莫
MDL NumberMFCD00057662
PubChem Substance ID135727212
EC Number208-524-3
Reaxys-RN1884446
Merck Number5980
Chemical Name Translation2-羟基-3-(2-甲氧基苯氧基)丙基 氨基甲酸酯
Beilstein Registry Number1884446
Wiswesser Line NotationZVO1YQ1OR BO1
LabNetwork Molecule IDLN01306146
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分类

  • {SNA} Alcohols
  • {SNA} Alcohols and Phenols,
  • {SNA} Analytical Standards,
  • {SNA} Alphabetical Index of Analytical Standards,
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Standards,
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Secondary Standards, Pharmaceutical Standards
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards,
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, G,
  • {SNA} Analytical Standards, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards L - M, 分析/色谱
  • {SNA} Additional Standards, Analytical Standards, Chromatography, Pharmaceutical Secondary Standards, Pharmaceutical Standards,
  • {SNA}

产品应用

  • A skeletal muscle relaxant.

相关文献及参考

  • Topliss, J., et al.: J. Med. Chem., 22, 1238

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P304+P340
  • P304+P340+P312
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P342+P311
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H302 Harmful if swallowed 吞食有害
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
RTECSTY8750000
Signal word Danger
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes Xn
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R42/43
Storage condition 储存温度-20°C 储存温度 2-8°C 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 1410 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - muscle weakness
   Behavioral - ataxia
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 129,75,1960

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 815 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 17,242,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1320 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - muscle wea

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 774 mg/kg
TOXIC EF

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 680 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   IJNEAQ International Journal of Neuropharmacology.

其他信息

  • Sigma Aldrich:532-03-6(sigmaaldrich)
  • 上游原料:氢氧化铵 --> 碳酸二乙酯 --> 愈创甘油醚
  • Methocarbamol 是一种中枢性肌肉松弛剂，用于治疗骨骼肌肉痉挛。
  • 甲氧卡巴莫
  • MOL 文件:532-03-6.mol
  • 用途一:用作解热镇痛药

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. G - Alphabetic
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Forensic and Veterinary Standards - Chromatography
  5. Drugs & Metabolites - Forensic and Veterinary Standards
  6. Neat Compounds - Drugs & Metabolites

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