Oxprenolol Hydrochloride 盐酸氧烯洛尔

CAS 6452-73-9 MFCD00058008

化学结构图

6452-73-9
SMILES: C=CCOc1ccccc1OCC(O)CNC(C)C.Cl

化学属性

Mol. FormulaC₁₅H₂₃NO₃ • HCl
Mol. Weight265.35 + (36.46)
Melting Point91-93°C
Boiling Point-
Flash Point-

别名和识别编码

Chemical NameOxprenolol Hydrochloride
CAS Number6452-73-9
Alfabeta NameOXPRENOLOLHYDROCHLORIDE
MDL Number-
Synonym (+-)-1-[o-(Allyloxy)phenoxy]-3-isopropylamino-2-propanol hydrochloride 1-(2'-Allyloxyphenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride 1-(2-Allyloxyphenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride 1-(o-Allyloxyphenoxy)-3-isopropylamino-2-propanol hydrochloride 1-(o-Allyloxyphenoxy)-3-isopropylamino-2-propranol-hydrochloride 1-(o-Allyloxyphenoxy)-3-isopropylaminopropan-2-ol hydrochloride 1-(o-allyloxyphenoxy)-3-isopropylamino-2-propanohydrochloride 1-(o-allyloxyphenoxy)-3-isopropylaminopropan-2-olhydrochloride 1-Isopropyl-amino-2-hydroxy-3-(O-allyloxyphenoxy)propane hydrochloride 1-Isopropylamino-3-(o-allyloxyphenoxy)-2-propanol hydrochloride 1-[(1-Methylethyl)amino]-3-[2-(2-propen-1-yloxy)phenoxy]- 1-[2-(ALLYLOXY)PHENOXY]-3-[ISOPROPYLAMINO]-2-PROPANOL HYDROCHLORIDE 1-[2-ALLYLOXY
Chemical Name Translation盐酸氧烯洛尔
EC Number229-260-5
Wiswesser Line Notation1Y1&M1YQ1OR BO2U1 &GH
LabNetwork Molecule IDLN00150970
PubChem Substance ID71172
InChIInChI=1S/C15H23NO3.ClH/c1-4-9-18-14-7-5-6-8-15(14)19-11-13(17)10-16-12(2)3;/h4-8,12-13,16-17H,1,9-11H2,2-3H3;1H
Canonical SMILES-
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分类

  • Amines
  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • ?-Adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic.

相关文献及参考

  • [2]. A S Manning, et al. Abrupt Withdrawal of Chronic Beta-Blockade: Adaptive Changes in Cyclic AMP and Contractility. J Mol Cell Cardiol. 1981 Nov;13(11):999-1009.
  • Garteiz, et al.: J. Pharmacol. Exp. Ther., 179, 354 (1971),
  • Taylor, S.H., et al.: N. Engl. J. Med., 307, 1293 (1982),
  • [1]. T Nagatomo, et al. Binding Characteristics of 3 H-dihydroalprenolol to Beta-Adrenoceptors of Rat Heart Treated With Neuraminidase. Jpn J Pharmacol. 1983 Aug;33(4):851-7.
  • [1]. T Nagatomo, et al. Binding Characteristics of 3 H-dihydroalprenolol to Beta-Adrenoceptors of Rat Heart Treated With Neuraminidase. Jpn J Pharmacol. 1983 Aug;33(4):851-7.
  • [2]. A S Manning, et al. Abrupt Withdrawal of Chronic Beta-Blockade: Adaptive Changes in Cyclic AMP and Contractility. J Mol Cell Cardiol. 1981 Nov;13(11):999-1009.

安全信息

Warnings IRRITANT
Hazard Codes Xi
RTECSUA5277000 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 90 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Cardiac - arrhythmias (including changes in conduction)
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   1,552,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 520 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 7,3131,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 940 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 18,164,1968

TYPE OF TEST            : LD90 - Lethal Dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Cardiac - pulse rate
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed.

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 21 mg/kg
SEX/DURATION            : female 7-13 day(s) after conception
TOXIC EFFE

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1400 mg/kg
SEX/DURATION            : female 8-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 7,3169,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 336 mg/kg
SEX/DURATION            : female 8-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 7,3169,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 700 mg/kg
SEX/DURATION            : female 8-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 7,3169,1973

Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H302 Harmful if swallowed 吞食有害
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P301+P310
  • P301+P312
  • P301+P316
  • P301+P317
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Storage condition -20°C -20°C, Inert atmosphere

其他信息

  • 急性毒性:口服-大鼠LD50: 900 毫克/公斤
  • 毒性分级:中毒
  • MOL 文件:6452-73-9.mol
  • 可燃性危险特性:可燃;燃烧产生有毒氮氧化物和氯化氢烟雾
  • Hazard Note:Irritant
  • 储运特性:库房通风低温干燥; 与食品原料分开存放
  • 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
  • 类别:有毒物品

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Adrenergic Receptor  (肾上腺素能受体)

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