• H315 Causes skin irritation 会刺激皮肤
• H317 May cause an allergic skin reaction 可能导致皮肤过敏
• H302 Harmful if swallowed 吞食有害
• H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
• H335 May cause respiratory irritation 可能导致呼吸道刺激
• H319 Causes serious eye irritation 严重刺激眼睛

• P342+P311
• P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
• P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
• P305+P351+P338

• S24 Avoid contact with skin 避免皮肤接触；
• S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
• S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
• S22 Do not breathe dust 不要吸入粉尘；

• R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
• R22 Harmful if swallowed 吞咽有害
• R42/43

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 45 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   APHRER Annals of Pharmacotherpy.  (Harvey Whitney Books Co., POB 42696,
   Cincinnati, OH 45242) V. 26-    1992-  Volume(issue)/page/year: 27,572,1993

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 37 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - rigidity (including catalepsy)
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   IJNEAQ International Journal of Neuropharmacology.  (New York, NY)  V.1-8,
   1962-69.  For publisher information, see NEPHBW.  Volume(issue)/page/year:
   4,111,1965

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 5 mg/kg/5D-I
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - toxic psychosis
REFERENCE :
   AJPSAO American Journal of Psychiatry.  (American Psychiatric Assoc.,
   Circulation Dept., 1400 K St., NW, Washington, DC 20005)  V.78-    1921-
   Volume(issue)/page/year: 142,386,1985

{hazard_c

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 315 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and

{ha

TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 260,99,1991

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Insect - not otherwise specified
DOSE/DURATION           : 10 gm/L
REFERENCE :
   JCLBA3 Journal of Cell Biology.  (Rockefeller Univ. Press, 1230 York Ave.,
   New York, NY 10003) V.12-    1962-  Volume(issue)/page/year: 47,182a,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 90 mg/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   DGDFA5 Development, Growth & Differentiation.  (Japan Pub. Trading Co.
   (USA), 1255 Howard St., San Francisco, CA 94103)  V.11-    1969-
   Volume(issue)/page/year: 22,61,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 130 mg/kg
SEX/DURATION            : female 10-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   NTOTDY Neurobehavioral Toxicology and Teratology.  (Fayetteville, NY) V.3-8,
   1981-86.  For publisher information, see NETEEC. Volume(issue)/page/year:
   7,493,1985