Flurazepam dihydrochloride 氟西泮 二盐酸盐

CAS 1172-18-5 MFCD00058189

化学结构图

1172-18-5
SMILES:

化学属性

Mol. FormulaC21H23ClFN3O · 2HCl
Mol. Weight460.80
Solubility45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <;6 mg/mL
Appearance solid

别名和识别编码

Chemical NameFlurazepam dihydrochloride
CAS Number1172-18-5
Synonym 盐酸氟安定 2h-1,4-benzodiazepin-2-one,7-chloro-1-(2-(diethylamino)ethyl)-5-(o-fluoropheny 7-CHLORO-1-(DIETHYLAMINO)ETHYL-5-(2-FLUOROPHENYL)-3H-1,4-BENZODIAZEPIN-2(1H)-ONE DIHYDROCHLORIDE 氟西泮盐酸盐 氟西泮 二盐酸盐 ######## Somlan dalmate dalmadorm NSC-78559 dalmadormhydrochloride Dalmane ro5-6901 ID 480 FLURAZEPAM DIHYDROCHLORIDE 7-氯-1-(二乙氨基)乙基-5-(2-氟苯基)-3H-1,4-苯并二氮杂-2(1H)-酮 二盐酸盐 felison id480dihydrochloride Dalmate insumin Flurazepam dihydrochloride Dormodor benozil Dalmadorm hydrochloride nsc-78559 Lunipax Benozil Ro 5-6901 盐酸氟西洋 Insumin dormodor FLURAZEPAM HYDROCHLORIDE FLURAZEPAM HCL lunipax id480 dalmane Dalmadorm ID 480 dihydrochloride 1,3-dihydro-l)dihydrochloride 盐酸氟西泮 Felison FLURAZEPAM DIHCL Flurazepam hydrochloride
MDL NumberMFCD00058189
EC Number214-630-0
PubChem Substance ID24894741
Chemical Name Translation氟西泮 二盐酸盐
Wiswesser Line NotationT67 GNV JN IHJ CG G2N2&2 KR BF &GH 2
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分类

  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Benzodiazepines and Anxiolytics, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, F, FA - FL, Neurobiology, Neuroscience, Pharmacologicals
  • Heterocycles
  • Pharmaceuticals
  • Amines
  • Intermediates & Fine Chemicals
  • Aromatics
  • {SNA} Benzodiazepines and Anxiolytics, Neurobiology, Neuroscience, Pharmacologicals, 细胞信号转导和神经科学, 细胞生物学

产品应用

  • Flurazepam is used as an sedative, hypnotic.

相关文献及参考

  • Sternbach, L.H., et al.: J. Med. Chem., 8, 815 (1965),
  • Schwartz, et al.: J. Med. Chem., 11, 770, (1968),
  • Armagnac, et al.: Therapie, 26, 439 (1971),

安全信息

GHS Symbol
Precautionary statements
  • P301+P310
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
WGK Germany3
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S1/2 None 上锁保管并避免儿童触及；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R33 Danger of cumulative effects 有累积作用的危险
Packing GroupIII
Hazard Class6.1(b)
Storage condition 2-8°C
UN Number 3249
RTECSDF0875000
Restrict {} 精神药品 精麻类化学品 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 568 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 178,216,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 186 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 26,741,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 596 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 152 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 26,741,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 440 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral

其他信息

  • Sigma Aldrich:1172-18-5(sigmaaldrich)
  • MOL 文件:1172-18-5.mol
  • color:light yellow
  • 用途一:适用于各种抑郁性精神障碍。

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Forensic and Veterinary Standards - Chromatography
  5. Drugs &amp; Metabolites - Forensic and Veterinary Standards
  6. Neat Compounds - Drugs &amp; Metabolites
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. F - Alphabetic
  5. FA - FL - F

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