2-(2-(4-((4-Chlorophenyl)(Phenyl)Methyl)Piperazin-1-Yl)Ethoxy)Ethanol Dihydrochloride 2-(2-(4-((4-氯苯基)(苯基)甲基)哌嗪-1-基)乙氧基)乙醇二盐酸盐

CAS 2192-20-3 MFCD00058200

化学结构图

2192-20-3
SMILES: Cl.Cl.OCCOCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1

化学属性

Mol. FormulaC21H27ClN2O2·2HCl
Mol. Weight448
Appearance 盐酸羟嗪(2192-20-3)为白色结晶性粉末。熔点193℃。易溶于水，溶于乙醇，不溶于乙醚。无臭，味苦。 powder
SolubilityH2O: soluble
Melting Point190-192°C

别名和识别编码

Chemical Name2-(2-(4-((4-Chlorophenyl)(Phenyl)Methyl)Piperazin-1-Yl)Ethoxy)Ethanol Dihydrochloride
CAS Number2192-20-3
Synonym ateraxdihydrochloride Ataraxoid dihydrochloride 2-[2-[4-(4-氯苯基)苯甲基-1-哌嗪基]乙氧基]-乙醇二盐酸盐 盐酸羟嗪 羟嗪 盐酸盐 Aterax dihydrochloride alamon ataraxoiddihydrochloride tran-qdihydrochloride Quies Alamon HYDROXYZINE HYDROCHLORIDE 2-[2-[4-[(4-Chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]ethanol Dihydrochloride tranquizinedihydrochloride ataraxdihydrochloride Ethanol, 2-2-4-(4-chlorophenyl)phenylmethyl-1-piperazinylethoxy-, dihydrochloride vistarilsteraject dichlorhydratede1-p.chlorbenzhydryl-4-(2-(2-hydroxyethoxy)ethyl)piperazine 2-(2-(4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)ethanoldihydrochl 2-[2-[4-[(4-chlorophenyl)phenymethyl]-1-piperazinyl]ethoxy]ethanol dihydrochloride Aterax Quiess Orgatrax 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-ethanodihydro 2-[2-[4-[(4-Chlorophenyl)phenymethyl]-1-piperazinyl]ethoxy]ethanol dihydrochloride Durrax HYDROXYZINE DIHYDROCHLORIDE orgatrax 2-(2-(4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)-ethanodihydroc 羟嗪盐酸盐 Atarax dihydrochloride 2-(2-(4-(p-Chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)ethanol 羟嗪 二盐酸盐 Atarax Hydroxyzine dihydrochloride neurolax 安泰乐
MDL NumberMFCD00058200
EC Number218-586-3
PubChem Substance ID24895830
Chemical Name Translation2-(2-(4-((4-氯苯基)(苯基)甲基)哌嗪-1-基)乙氧基)乙醇二盐酸盐
LabNetwork Molecule IDLN03267692
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} Application Index, Biochemicals and Reagents, Cell Signaling Enzymes, Drug and Xenobiotic Metabolism, Enzymes, Inhibitors, and Substrates, H, Inhibitors, Multi-Drug Resistance and Drug Metabolism, Substrates, Inducers, Inhibitors, Xenobiotics and Drug Metabolism, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Application Index, Bioactive Small Molecule Alphabetical Index, Cell Signaling Enzymes, Drug and Xenobiotic Metabolism, H, Inhibitors, Multi-Drug Resistance and Drug Metabolism, Substrates, Inducers, Inhibitors, Xenobiotics and Drug Metabolism, 生化试剂, 生物活性小分子,

产品应用

  • H1 receptor antagonist. Anxiolytic. Antihistaminic.

相关文献及参考

  • [2]. Morichi, R. and G. Pepeu, A study of the influence of hydroxyzine and diazepam on morphine antinociceptoion in the rat. Pain, 1979. 7(2): p. 173-80.
  • [3]. Nikita Shekhar Sawantdesai, et al. Evaluation of anxiolytic effects of aripiprazole and hydroxyzine as a combination in mice. J Basic Clin Pharm. 2016 Sep;7(4):97-104.
  • Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971),
  • [1]. Minogiannis, P., et al., Hydroxyzine inhibits neurogenic bladder mast cell activation. Int J Immunopharmacol, 1998. 20(10): p. 553-63.
  • [1]. Minogiannis, P., et al., Hydroxyzine inhibits neurogenic bladder mast cell activation. Int J Immunopharmacol, 1998. 20(10): p. 553-63.
  • [2]. Morichi, R. and G. Pepeu, A study of the influence of hydroxyzine and diazepam on morphine antinociceptoion in the rat. Pain, 1979. 7(2): p. 173-80.
  • [3]. Nikita Shekhar Sawantdesai, et al. Evaluation of anxiolytic effects of aripiprazole and hydroxyzine as a co

安全信息

Hazard Codes Xn
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
RTECSKK2280000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 500 ug/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
   HUPSEC Human Psychopharmacology.  (John Wiley & Sons Ltd., Baffins Lane,
   Chichester, W.Sussex PO19 1UD, United Kingdom)  V.1-    1986-
   Volume(issue)/page/year: 7,25,1992

其他信息

  • Sigma Aldrich:2192-20-3(sigmaaldrich)
  • MOL 文件:2192-20-3.mol
  • 用途一:具有安定及松驰横纹肌的作用，也有抗组织织胺作用和胆碱作用，适用于轻度紧张、焦虑、不安。
  • 方法一:由1-[2-（2-羟乙氧基）乙基]哌嗪（见21815）与对氯二苯氯甲烷缩合、成盐而得。
  • 上游原料:二苯氯甲烷 --> 1-(2-(2-羟乙氧基)乙基)哌嗪

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Application Index - Enzymes, Inhibitors, and Substrates
  5. Cell Signaling Enzymes - Application Index
  6. Xenobiotics and Drug Metabolism - Cell Signaling Enzymes
  7. Inhibitors - Xenobiotics and Drug Metabolism
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Multi-Drug Resistance and Drug Metabolism - Cell Signaling and Neuroscience
  5. Drug and Xenobiotic Metabolism - Multi-Drug Resistance and Drug Metabolism
  6. Substrates, Inducers, Inhibitors - Drug and Xenobiotic Metabolism
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Histamine Receptor  (组胺受体)

相关产品推荐