Dihydroergotamine Mesylate 双氢麦角胺甲磺酸盐
CAS 6190-39-2 MFCD00058615
化学结构图
SMILES: CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21.CS(=O)(=O)O
化学属性
| Mol. Formula | C33H37N5O5·CH4O3S |
|---|---|
| Mol. Weight | 679.79 |
别名和识别编码
| Chemical Name | Dihydroergotamine Mesylate |
|---|---|
| MDL Number | MFCD00058615 |
| CAS Number | 6190-39-2 |
| PubChem Substance ID | 71171 |
| EC Number | 228-235-6 |
| Synonym | 9,10-Dihydroergotamine mesylate Agit Angionorm Clavigrenin D Tamin retard L.U.T. D-Tamin retard L.U.T. D.H.E. 45 DET MS DETMS DHE 45 DHE Puren DHE ratiopharm DHE-45 DHE-Puren DHE-ratiopharm DHE45 Dihydergot Dihydroergotamin AL Dihydroergotamine Dihydroergotamine Mesylate Dihydroergotamine Methanesulfonate Dihydroergotamine Sandoz Dihydroergotamine mesilate Dihydroergotamine mesylate Dihydroergotamine methanesulfonate Dihydroergotamine-Sandoz Dihytamin Dihytamine Erganton Ergomimet Ergont Ikaran Mesylate, Dihydroergotamine Methanesulfonate, Dihydroergotamine Migranal Orstanor |
| InChIKey | QHZUABXEBRGBLP-LKWYKXIFSA-N |
| Chemical Name Translation | 双氢麦角胺甲磺酸盐 |
| Reaxys-RN | 6473411 |
| Merck Number | 3174 |
| InChI | InChI=1S/C33H37N5O5.CH4O3S/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32;1-5(2,3)4/h3-6,8-11,17,21,23,25-27,34,42H,7,12-16,18H2,1-2H3,(H,35,39);1H3,(H,2,3,4)/t21-,23-,25-,26+,27+,32-,33+;/m1./s1 |
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分类
- {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DIG-DY, Ergot Alkaloids, Neurobiology, Neuroscience, Pharmacologicals
- {SNA} Ergot Alkaloids, Neurobiology, Neuroscience, Pharmacologicals, 细胞信号转导和神经科学, 细胞生物学
相关文献及参考
- [2]. Saper, J.R., et al., DHE in the pharmacotherapy of migraine: potential for a larger role. Headache, 2006. 46 Suppl 4: p. S212-20.
- [3]. Schaerlinger, B., et al., Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy. Br J Pharmacol, 2003. 140(2): p. 277-84.
- [1]. Colman, I., et al., Parenteral dihydroergotamine for acute migraine headache: a systematic review of the literature. Ann Emerg Med, 2005. 45(4): p. 393-401.
- [1]. Colman, I., et al., Parenteral dihydroergotamine for acute migraine headache: a systematic review of the literature. Ann Emerg Med, 2005. 45(4): p. 393-401.
- [2]. Saper, J.R., et al., DHE in the pharmacotherapy of migraine: potential for a larger role. Headache, 2006. 46 Suppl 4: p. S212-20.
- [3]. Schaerlinger, B., et al., Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy. Br J P
安全信息
GHS Symbol
- H302+H312+H332
- H312 Harmful in contact with skin 皮肤接触有害
- H332 Harmful if inhaled 吸入有害
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P302+P352
- P302+P352+P312+P362+P364
- P304+P312
- P304+P340
- P304+P340+P312
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
- P317
- P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
- P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
- P362+P364
- P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,328,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,468,1990
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,468,1990
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