DL-2-Aminoadipic Acid 2-氨基己二酸

CAS 542-32-5 MFCD00063119

化学结构图

542-32-5
SMILES: NC(CCCC(=O)O)C(=O)O

化学属性

Mol. FormulaC6H11NO4
Mol. Weight161.16
Melting Point196-198°C
TSCANo
Density1.333
Boiling Point287.44 °C at 760 mmHg

别名和识别编码

Chemical NameDL-2-Aminoadipic Acid
Synonym Aminoadipic acid {LY} Aminoadipic acid {} {LY} Aminoadipic acid {} {} {LY} Aminoadipic acid {} {} {} {LY} Aminoadipic acid {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {} {} {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {
MDL NumberMFCD00063119
PubChem Substance ID469
CAS Number542-32-5
EC Number208-809-2
Merck Number14,416
Beilstein Registry Number1773077
Chemical Name Translation2-氨基己二酸
LabNetwork Molecule IDLN00196314
InChIInChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)
Canonical SMILESO=C(O)C(N)CCCC(O)=O
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分类

  • {SNA} Enzyme Inhibitors, Glutamine Synthetase, Neuroscience, Neurotransmission, Neurotransmitter Metabolism, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} A-AM, Bioactive Small Molecules, Cell Signaling and Neuroscience, Enzyme Inhibitors, Glutamine Synthetase, Neuroscience, Neurotransmission, Neurotransmitter Metabolism, 细胞生物学
  • {SNA} A-AM, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Glutamine Synthetase, Neuroscience, Neurotransmission, Neurotransmitter Metabolism

产品应用

  • 谷氨酰胺合成酶抑制剂,胶霉毒素(gliotoxin)。

相关文献及参考

  • [2]. Wang X, et al. α-Aminoadipic acid protects against retinal disruption through attenuating Müller cell gliosis in a rat model of acute ocular hypertension. Drug Des Devel Ther. 2016 Oct 20;10:3449-3457.
  • Alvarez-Maubecin, V., et al., Functional coupling between neurons and glia. J. Neurosci. 20 , 4091-4098, (2000) 摘要
  • Merck 14 ,416
  • Merck:14,416
  • Merck:14,416 Beilstein: 4,495
  • Tsai MJ, et al, Characterization of L -alpha-aminoadipic acid transport in cultured rat astrocytes. Brain Res. 741 , 166, (1996) 摘要
  • [1]. Wang TJ, et al. 2-Aminoadipic acid is a biomarker for diabetes risk. J Clin Invest. 2013 Oct;123(10):4309-17.
  • [1]. Wang TJ, et al. 2-Aminoadipic acid is a biomarker for diabetes risk. J Clin Invest. 2013 Oct;123(10):4309-17.
  • [2]. Wang X, et al. α-Aminoadipic acid protects against retinal disruption through attenuating Müller cell gliosis in a rat model of acute ocular hypertension. Drug Des Devel Ther.

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P333+P313
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
Hazard Codes Xi
Signal word Warning
RTECSMO1852000
Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light 2-8℃ {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
Risk Statements
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   5,108,1960

其他信息

  • 微溶于醇和醚。
  • Sigma Aldrich:542-32-5(sigmaaldrich)
  • 2-氨基己二酸水合物价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 154500010 2-氨基己二酸水合物 DL-2-Aminoadipic acid hydrate 97% 1 GR 660元 2010/06/21 154500250 2-氨基己二酸水合物 DL-2-Aminoadipic acid hydrate 97% 25 GR 9370元 2010/06/21 154500050 2-氨基己二酸水合物 DL-2-Aminoadipic acid hydrate 97% 5 GR 2476元
  • Acros Organics:2-氨基己二酸水合物 DL-2-Aminoadipic acid hydrate, 97%(542-32-5)
  • Alfa Aesar:DL-2-氨基己二酸,98% DL-2-Aminoadipic acid, 98%(542-32-5)
  • MOL 文件:542-32-5.mol
  • 图谱信息:2-氨基己二酸水合物(542-32-5)质谱(MS) 2-氨基己二酸水合物(542-32-5)红外图谱(IR2) 2-氨基己二酸水合物(542-32-5)红外图谱(IR1)

系列性分类


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