DL-2-Aminoadipic Acid 2-氨基己二酸

CAS 542-32-5 MFCD00063119

化学结构图

542-32-5
SMILES: NC(CCCC(=O)O)C(=O)O

化学属性

Mol. FormulaC6H11NO4
Mol. Weight161.16
Melting Point196-198°C
TSCANo
Density1.333
Boiling Point287.44 °C at 760 mmHg

别名和识别编码

Chemical NameDL-2-Aminoadipic Acid
Synonym Aminoadipic acid {LY} Aminoadipic acid {} {LY} Aminoadipic acid {} {} {LY} Aminoadipic acid {} {} {} {LY} Aminoadipic acid {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {} {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {} {} {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aminoadipic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00063119
PubChem Substance ID469
CAS Number542-32-5
EC Number208-809-2
Merck Number14,416
Beilstein Registry Number1773077
Chemical Name Translation2-氨基己二酸
LabNetwork Molecule IDLN00196314
InChIInChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)
Canonical SMILESO=C(O)C(N)CCCC(O)=O
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分类

  • {SNA} Enzyme Inhibitors, Glutamine Synthetase, Neuroscience, Neurotransmission, Neurotransmitter Metabolism, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} A-AM, Bioactive Small Molecules, Cell Signaling and Neuroscience, Enzyme Inhibitors, Glutamine Synthetase, Neuroscience, Neurotransmission, Neurotransmitter Metabolism, 细胞生物学
  • {SNA} A-AM, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Glutamine Synthetase, Neuroscience, Neurotransmission, Neurotransmitter Metabolism

产品应用

  • 谷氨酰胺合成酶抑制剂，胶霉毒素(gliotoxin)。

相关文献及参考

  • [2]. Wang X, et al. α-Aminoadipic acid protects against retinal disruption through attenuating Müller cell gliosis in a rat model of acute ocular hypertension. Drug Des Devel Ther. 2016 Oct 20;10:3449-3457.
  • Alvarez-Maubecin, V., et al., Functional coupling between neurons and glia. J. Neurosci. 20 , 4091-4098, (2000) 摘要
  • Merck 14 ,416
  • Merck:14,416
  • Merck:14,416 Beilstein: 4,495
  • Tsai MJ, et al, Characterization of L -alpha-aminoadipic acid transport in cultured rat astrocytes. Brain Res. 741 , 166, (1996) 摘要
  • [1]. Wang TJ, et al. 2-Aminoadipic acid is a biomarker for diabetes risk. J Clin Invest. 2013 Oct;123(10):4309-17.
  • [1]. Wang TJ, et al. 2-Aminoadipic acid is a biomarker for diabetes risk. J Clin Invest. 2013 Oct;123(10):4309-17.
  • [2]. Wang X, et al. α-Aminoadipic acid protects against retinal disruption through attenuating Müller cell gliosis in a rat model of acute ocular hypertension. Drug Des Devel Ther.

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P333+P313
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
Hazard Codes Xi
Signal word Warning
RTECSMO1852000
Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light 2-8℃ {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {}
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Risk Statements
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   5,108,1960

其他信息

  • 微溶于醇和醚。
  • Sigma Aldrich:542-32-5(sigmaaldrich)
  • 2-氨基己二酸水合物价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 154500010 2-氨基己二酸水合物 DL-2-Aminoadipic acid hydrate 97% 1 GR 660元 2010/06/21 154500250 2-氨基己二酸水合物 DL-2-Aminoadipic acid hydrate 97% 25 GR 9370元 2010/06/21 154500050 2-氨基己二酸水合物 DL-2-Aminoadipic acid hydrate 97% 5 GR 2476元
  • Acros Organics:2-氨基己二酸水合物 DL-2-Aminoadipic acid hydrate, 97%(542-32-5)
  • Alfa Aesar:DL-2-氨基己二酸,98% DL-2-Aminoadipic acid, 98%(542-32-5)
  • MOL 文件:542-32-5.mol
  • 图谱信息:2-氨基己二酸水合物(542-32-5)质谱(MS) 2-氨基己二酸水合物(542-32-5)红外图谱(IR2) 2-氨基己二酸水合物(542-32-5)红外图谱(IR1)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Organic Acids - Synthetic Reagents
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids - Carbonyl Compounds
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurotransmission - Neuroscience
  6. Neurotransmitter Metabolism - Neurotransmission
  7. Enzyme Inhibitors - Neurotransmitter Metabolism
  8. Glutamine Synthetase - Enzyme Inhibitors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Neuroscience
  5. Neurotransmission
  6. Neuropeptides
  7. Angiotensin Metabolism
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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