2H,1,4-Benzodiazepin-2-one,7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy- 劳拉西泮

CAS 846-49-1 MFCD00063406

化学结构图

846-49-1
SMILES: O=C1Nc2ccc(Cl)cc2C(c2ccccc2Cl)=NC1O

化学属性

Mol. FormulaC15H10Cl2N2O2
Mol. Weight321.17
Flash Point11 °C
Melting Point166-168°C

别名和识别编码

Chemical NameLorazepam
CAS Number846-49-1
Synonym (±)-Lorazepam EMOTIVAL LORSILAN 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one Tavor Temesta 氯羟安定(率羟去甲安定) Lorazepam o-Chlorooxazepam 劳拉西泮 Demethyllormetazepam norlormetazepam (+/-)-LORAZEPAM 氯羟去甲安定 Ativan (+-)-lorazepammethanolsolution AURORA KA-7219 Wypax 1,4-benzodiazepin-2-one,7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2 delormetazepam LORAZEPAM o-Chloroxazepam Delormetazepam 氯羟安定 Wy-4036 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy- Almazine Norlormetazepam 罗拉 Lorsilan Emotival WY 4036 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one LORAX Lorax demethyllormetazepam 7-CHLORO-5-[2-CHLOROPHENYL]-1,3-DIHYDRO-3-HYDROXY-2H-1,4-BENZODIAZEPIN-2-ONE 7-氯-5-(2-氯苯基)-3-羟基-1,3-二氢-2H-1,4-苯二氮卓-2-酮 ATIVAN
MDL NumberMFCD00063406
PubChem Substance ID3958
EC Number212-687-6
Chemical Name Translation劳拉西泮
Wiswesser Line NotationT67 GMV JN IHJ CG IQ KR BG
Beilstein Registry Number0759084
InChIInChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)
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分类

  • Approved Therapeutics/Drug Candidates, Baxter, Benzodiazepines and Anxiolytics, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, L, Neurobiology, Neuroscience, Pharmacologicals
  • {SNA} Approved Therapeutics/Drug Candidates, Baxter, Benzodiazepines and Anxiolytics, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, L, Neurobiology, Neuroscience, Pharmacologicals

产品应用

  • An anxiolytic, and anticonvulsant.

相关文献及参考

  • Rutgers, G., et al.: Anal. Profiles Drug Subs., 9, 397 (1980),
  • Korkmaz, S., et al.: Eur. Neuropsychopharmacol., 8, 175 (1998),
  • D?Onofrio, G., et al.: N. Engl. J. Med., 340, 915 (1999),
  • Korkmaz, S., et al. Eur. Neuropsychopharmacol. 8 , 175, (1998) 摘要
  • Merck 14 ,5579

安全信息

RTECSDF0350000
WGK Germany3
GHS Symbol
Precautionary statements
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
Signal word Warning
Hazard statements
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
Hazard Codes Xn Xn,T,F
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
Risk Statements
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R11 Highly flammable 非常易燃
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性:吸入,皮肤接触和吞食都会产生十分严重的不可逆危险
Storage condition -20°C
UN Number UN 1230 3/PG 2
Restrict {} 精神药品 精麻类化学品
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >25 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Gastrointestinal - nausea or vomiting
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 21,1065,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1850 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-c

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JZKEDZ Jitchuken Zenrinsho Kenkyuho.  Central Institute for Experimental
   Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
   Takatsu-ku, Kawasaki 211, Japan)  V.1-    1975-  Volume(issue)/page/year:
   1(1

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 1208 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - pleural thickening
REFERENCE :
   PECAE5 Pediatric Emergency Care.  (Williams & Wilkins, 428 E. Preston St.,
   Baltimore, MD  21202) V.1-    1985-  Volume(issue)/page/year: 11,32,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 242

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 16 mg/kg
SEX/DURATION            : female 13-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   NEPHBW Neuropharmacology.  (Pergamon Press Ltd., Headington Hill Hall,
   Oxford OX3 OBW, UK) V.9-    1970-  Volume(issue)/page/year: 30,53,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 14 mg/kg
SEX/DURATION            : female 14-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   PBBHAU Pharmacology, Biochemistry and Behavior.  (ANKHO International Inc.,
   P.O. Box 426, Fayetteville, NY 13066)  V.1-    1973-
   Volume(issue)/page/year: 51,721,1995

TYPE OF TEST            : TDLo - Lowest published toxic dos

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 2420 ug/kg
SEX/DURATION            : female 36-39 week(s) after conception
                          lactating female 2 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - other neonatal measures or effects
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   282,1106,1981

TYPE OF

其他信息

  • Sigma Aldrich:846-49-1(sigmaaldrich)
  • 可燃性危险特性:热分解排出有毒氮氧化物, 氯化物烟雾
  • 类别:有毒物质
  • 毒性分级:中毒
  • 储运特性:库房低温通风干燥
  • 急性毒性:口服-大鼠 LD50: 4500 毫克/公斤; 口服-小鼠 LD50: 1850 毫克/公斤
  • 上游原料:氯乙酰氯 --> 2,5-二氯二苯甲酮
  • MSDS 信息:7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one(846-49-1).msds
  • 方法一:2-氨基2',5-二氯二苯甲酮依次与羟胺、氯乙酰氯、甲胺反应,然后与乙酐反应制得3-醋酸基-7-氯-5-(邻氯苯)-1,3-二氢-2H-1,4-苯并二氮-2-酮,再用氢氧化钠溶液处理,得到白色固体沉淀,过滤,水洗,用乙醇结晶,即得氯羟安定。
  • 灭火剂:水,二氧化碳, 泡沫, 干粉
  • 用途一:该品具有镇静、肌肉松弛和抗惊厥作用。催眠作用较强,可持续8小时。
  • MOL 文件:846-49-1.mol

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