(S)-2-Acetamido-N-((S)-1-Amino-4-Methyl-1-Oxopentan-2-yl)-4-Methyl-N-((S)-1-Oxohexan-2-yl)Pentanamide N-乙酰基-L-亮氨酰基-L-亮氨酰基-L-正亮氨酸醛

CAS 110044-82-1 MFCD00065505

化学结构图

110044-82-1
SMILES: CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C=O

化学属性

Mol. FormulaC20
Mol. Weight384

别名和识别编码

Chemical Name(S)-2-Acetamido-N-((S)-1-Amino-4-Methyl-1-Oxopentan-2-yl)-4-Methyl-N-((S)-1-Oxohexan-2-yl)Pentanamide
Synonym ALLN ALLN Ac-LLnL-CHO MG-101 N-Acetyl-Leu-Leu-Norleu-al N-Acetyl-L-leucyl-L-leucyl-L-norleucinal Ac-LLnL-CHO Calpain Inhibitor I MG-101 N-Acetyl-L-leucyl-L-leucyl-L-norleucinal N-Acetyl-Leu-Leu-Norleu-al
MDL NumberMFCD00065505
PubChem Substance ID24891066
Beilstein Registry Number7656053
CAS Number110044-82-1
Chemical Name TranslationN-乙酰基-L-亮氨酰基-L-亮氨酰基-L-正亮氨酸醛
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分类

  • {SNA} Aldehydes, Bioactive Small Molecules, Biochemicals and Reagents, Building Blocks, C-CH, C13-C60, Carbonyl Compounds, Cell Biology, Chemical Synthesis, Enzyme Inhibitors, Enzyme Inhibitors by Type,
  • {SNA} Aldehydes, Building Blocks, C13-C60, Carbonyl Compounds, Chemical Synthesis, Enzyme Inhibitors, Enzyme Inhibitors by Type, Organic Building Blocks, Substrate Analogs, 生化试剂, 酶、抑制剂和底物
  • {SNA} A to C, Aldehydes, Apoptosis Enzymes, Application Index, Bioactive

相关文献及参考

  • 1. Lu, Q., Mellgren, R.L., Calpain inhibitors and serine protease inhibitors can produce apoptosis in HL-60 cells. Arch. Biochem. Biophys. 334 , 175, (1996) 摘要
  • 2. Squier, M.K., Calpain activation in apoptosis. J. Cell Physiol. 159 , 229, (1994) 摘要
  • 3. Griscavage, J.M., Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-κ B. Proc. Natl. Acad. Sci. U. S. A. 93 , 3308, (1996) 摘要
  • 4. Sherwood, S.W., In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetyl­leucylleucyl­norleucinal. Proc. Natl. Acad. Sci. U. S. A. 90 , 3353, (1993) 摘要
  • Hoffman, L., Rechsteiner M., Nucleotidase activities of the 26S proteasome and its regulatory complex. J. Biol. Chem. 271 , 32538, (1996) 摘要
  • Liu, D., et al., Activation of calpains mediates early lung neutrophili

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

系列性分类


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