1-((5-Chloronaphthalen-1-yl)sulfonyl)-1,4-diazepane hydrochloride 1-((5-氯萘-1-基)磺酰基)-1,4-二氮杂环庚烷盐酸盐

CAS 105637-50-1 MFCD00065525

化学结构图

105637-50-1
SMILES: Cl.O=S(=O)(C1C=CC=C2C(Cl)=CC=CC=12)N1CCCNCC1

化学属性

Mol. FormulaC15H17N2O2SCl · HCl
Mol. Weight361.29

别名和识别编码

Chemical Name1-((5-Chloronaphthalen-1-yl)sulfonyl)-1,4-diazepane hydrochloride
CAS Number105637-50-1
Synonym 1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride ML-9
MDL NumberMFCD00065525
PubChem Substance ID24278297
Chemical Name Translation1-((5-氯萘-1-基)磺酰基)-1,4-二氮杂环庚烷盐酸盐
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分类

  • {SNA} Bioactive Small Molecule Alphabetical Index, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Kinase/Phosphatase Biology, L to O, M, Myosin Light Chain Kinase, Myosin Light Chain Kinase (MLCK), P to Q, Protein Kinase Inhibitors, Protein kinase A, Protein kinase C, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
  • Protein Kinase Inhibitors and Activators
  • {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors,

产品应用

  • Inhibits the catalytic activities of several protein kinases competitively with respect to ATP and exhibited different Ki values toward each protein kinase. Also found to be a new type of vascular re

相关文献及参考

  • [2]. Shaikh S, et al. The STIM1 inhibitor ML9 disrupts basal autophagy in cardiomyocytes by decreasing lysosome content.Toxicol In Vitro. 2018 Apr;48:121-127.
  • [3]. Kondratskyi A1, et al.Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death.Cell Death Dis. 2014 Apr 24;5:e1193.
  • Hidaka, H., et al.: J. Biol. Chem., 262, 16, 7796 (1987)
  • [1]. Ito S, et al. ML-9, a myosin light chain kinase inhibitor, reduces intracellular Ca2+ concentration in guinea pig trachealis.Eur J Pharmacol. 2004 Feb 23;486(3):325-33.
  • [1]. Ito S, et al. ML-9, a myosin light chain kinase inhibitor, reduces intracellular Ca2+ concentration in guinea pig trachealis.Eur J Pharmacol. 2004 Feb 23;486(3):325-33.
  • [2]. Shaikh S, et al. The STIM1 inhibitor ML9 disrupts basal autophagy in cardiomyocytes by decreasing lysosome content.Toxicol In Vitro. 2018 Apr;48:121-127.
  • [3]. Kondratskyi A1, et al.Identification of ML-9 as a lysosomotropic a

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

系列性分类


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