Norethindrone 炔诺酮

CAS 68-22-4 MFCD00067596

化学结构图

68-22-4
SMILES: C[C@@]12CC[C@H]3[C@@H]4CCC(=O)C=C4CC[C@@H]3[C@H]1CC[C@]2(O)C#C |&1:1,4,5,14,15,18|

化学属性

Mol. FormulaC20H26O2
Mol. Weight298
Melting Point205-206
SolubilityDMSO 60 mg/mL Water <1 mg/mL Ethanol 5 mg/mL
Appearance powder

别名和识别编码

Chemical NameNorethindrone
CAS Number68-22-4
Synonym (17?)-17-Hydroxy-19-norpregn-4-en-20-yn-3-one (8R,9S,10R,13S, 17-Ethynyl-19-nortestosterone, 17-Hydroxy-19-nor-17-4-pregnen-20-yn-3-one, 17-Ethynyl-17-hydroxy-19-nor-4-androsten-3-one, 19-Nor-17-ethynyl-4-androsten-17-ol-3-one, 19-Norethisterone 17-HYDROXY-19-NOR-17ALPHA-4-PREGNEN-20-YN-3-ONE 17-Hydroxy-19-nor-17α-p 17-alpha-Ethinylestra-4-en-17-beta-ol-3-one 17-alpha-Ethynyl-17-beta-hydroxyestr-4-en-3-one 17-alpha-Ethynyl-4-estren-17-ol-3-one 17-hydroxy-19-nor-17a-pregn-4-en-20-yn-3-one 17ALPHA-ETHYNYL-19-NORTESTOSTERONE 17α-Eth 17α-Ethinyl-17β-hydroxy-Δ4-estren-3-one 17α-Ethinyl-19-nortestosterone 17α-Ethynyl-17-hydroxy-4-estrene-3-one 17α-Ethynyl-17-hydroxyest-4-en-3-one 17α-Ethynyl-17-hydroxyestr-4-en-3-one 17α-Ethynyl-17β-hydroxy-19-norandrost-4-en-3-one
MDL NumberMFCD00067596
PubChem Substance ID24897669
Beilstein Registry Number1915671
EC Number 200-681-6
Chemical Name Translation炔诺酮
Merck Number6697
Wiswesser Line NotationL E5 B666 OV MUTJ E FQ F1UU1 -A&F
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分类

  • {SNA} Analytical Standards,
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards N - O, Pharmaceutical Standards, Pharmacopeia Standards
  • {SNA} Bioactive Small Molecules, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, N, Other Steroid Products, Steroid Hormones, 细胞生物学
  • {SA} Alphabetic, Analytical Standards, Analytical/
  • {SNA} Analytical Standards, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards N - O, 分析/色谱
  • {SNA} Analytical Standards, Pha

产品应用

  • Progesteron. Norethindrone and acetate in combination with estrogen as contraceptive (oral). It is reasonably anticipated to be a human carcinogen.

相关文献及参考

  • Schroff, A. P., et al.: Anal. Profiles Drug Subs., 4, 268 (1975),
  • Singh, H., et al.: Am. J. Obstet. Gynecol., 135, 409 (1979),
  • Toews, M., et al.: Curr. Ther. Res, 41, 509 (1987),
  • Merck 14 ,6697
  • Beil. 8 ,IV,1221
  • Corp MSDS 1 (2), 2625:C / FT-IR 2 (3), 4238:C / FT-NMR 1 (3), 591:B / RegBook 1 (2), 2867:D / Sax 6 , 1587 / Sigma FT-IR 1 (1), 1288:B / Structure Index 1 , 459:D:3
  • Short: IV/8A Title: Enthalpies of Fusion and Transition of Organic Compounds Author: Zhang, Z.-Y.; Frenkel, M.; March, K.N.; Wilhoit, R.C. Editor: Marsh, K.N. Source: Landolt-Börnstein, New Series Volume: IV/8A Year: 1995 Keyword: organic compounds; enthaly of fusion; melting point; phase transition ISBN: 3-540-58854-X ISBN: 978-3-540-58854-2 Internet Resource: DOI:10.1007/b55145 RefComment: VIII, 588 pages.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

RTECSRC8975000
GHS Symbol
Precautionary statements
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
Hazard statements
  • H351 Suspected of causing cancer 怀疑致癌
Hazard Codes Xn
WGK Germany3
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges dust mask type N95 (US), Eyeshields, Gloves
Signal word Warning
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
Storage condition 储存温度-20°C 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 166 mg/kg/77W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - increased incidence of tumors in susceptible strains
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 212,686,1966

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 163 mg/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Reproductive - Tumorigenic effects - ovarian tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   21,153,1967

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 168 mg/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Reproductive - Tumorigenic effects - ovarian tumors
REFERENCE :
   PMDFA9 Pakistan Medical Forum.  (Karachi, Pakistan) V.1-8, 1966-73(?)  Disc
   ontinued.  Volume(issue)/page/year: 7,21,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 42 mg/kg
TOXIC EFFECTS :
   Endocrine - androgenic
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 84,962,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,809,1990

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 50 umol/L
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 146,401,1974

其他信息

  • 下游产品:
  • MOL 文件:68-22-4.mol
  • 上游原料:四氢呋喃
  • 用途一:孕激素类药，用于月经不调、子宫功能性出血、子宫内膜异位症等
  • color:white to off-white
  • Sigma Aldrich:68-22-4(sigmaaldrich)
  • 炔诺酮

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Market Segments - Analytical Standards
  4. Standards for Pharma Clinical Forensic &amp; Veterinary Analysis - Market Segments
  5. Neats and Solutions - Standards for Pharma Clinical Forensic &amp; Veterinary Analysis
  6. Hormones - Neats and Solutions
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Other Steroid Products - Steroid Hormones
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Acetylenes 炔烃
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Steroids

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