(R)-(-)-Benzyl Glycidyl Ether (R)-苄氧甲基环氧乙烷

CAS 14618-80-5 MFCD00068409

化学结构图

14618-80-5
SMILES: C(OCc1ccccc1)[C@H]1CO1

化学属性

Mol. FormulaC10H12O2
Mol. Weight164
Refractive index1.5150 to 1.5190
Density1.08
Flash Point>110°(230°F)
TSCANo
Boiling Point130

别名和识别编码

Chemical Name(R)-(-)-Benzyl Glycidyl Ether
Synonym (-)-BENZYL (R)-GLYCIDYL ETHER (R)-(-)-1-BENZYLOXY-2,3-EPOXYPROPANE (R)-(-)-2-(BENZYLOXYMETHYL)OXIRANE (R)-(-)-2-(Benzyloxymethyl)oxirane (R)-(-)-BENZYL GLYCIDYL ETHER (R)-(-)-Benzyloxymethyloxirane (S)-吗啡呤-3-甲酸 -(−)-2-(Benzyloxymethyl)oxirane 1-(4-异丙基苯基)哌嗪 1-对甲苯基环丁基甲酸 1-对甲苯基环丁腈 1-对甲苯基环戊基甲酸 1-苄基-氮杂环庚烷-3-酮 2'-脱氧胸苷-5'-磷酸二钠 3-epoxy-1-(benzyloxy)-(r)-propan 5-TMP,2Na 6-羟基-1,2,3,4-四氢异喹啉 N-BOC-2-丙基-氮杂环丁烷 NULL R-苄氧甲基环氧乙烷 RARECHEM AK HZ 0049 {} {} {Chemica
CAS Number14618-80-5
PubChem Substance ID87565092
Beilstein Registry Number5246495
MDL NumberMFCD00068409
Reaxys-RN5246495
EC Number250-023-7
Chemical Name Translation(R)-苄氧甲基环氧乙烷
InChIKeyQNYBOILAKBSWFG-JTQLQIEISA-N
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分类

  • Asymmetric Synthesis, Chemical Synthesis, Chiral Building Blocks, Epoxides, Organic Building Blocks
  • {SNA} Asymmetric Synthesis, Chemical Synthesis, Chiral Building Blocks, Epoxides, Organic Building Blocks

产品应用

  • 用于制备康帕丁和洛伐他汀的内酯片段。1制备顺-1,3-多元醇、2二脱氧核苷3和螺缩醛氰醇的手性子。

相关文献及参考

  • 1. Synthesis , 539, (1989)
  • 2. J. Org. Chem. 53 , 4495, (1988)
  • 3. J. Med. Chem. 32 , 76, (1989) 摘要
  • 4. J. Chem. Soc., Chem. Commun. , 291, (1993)
  • FT-IR 2 (2), 1817:B / RegBook 1 (1), 1251:L / Structure Index 1 , 191:C:6

安全信息

GHS Symbol
WGK Germany3
Hazard Codes Xi
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSTX2860030
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
Signal word Warning
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Storage condition 贮存温度:2-8°C 
TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 298,197,1993

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 298,197,1993

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 660 nmol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 298,197,1993

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 298,197,1993

其他信息

  • 检测方法:HPLC,Optical Rotatory Dispersion
  • 用途一:用于合成多种手性医药中间体
  • Acros Organics:?-苄氧甲基环氧乙烷 (R)-(-)-Benzyl glycidyl ether(14618-80-5)
  • Alfa Aesar:苄基(R)-(-)-缩水甘油基醚,98+% Benzyl (R)-(-)-glycidyl ether, 98+%(14618-80-5)
  • 比旋光度:-5.4 ° (c=5 in toluene)
  • TCI Shanghai:(R)-(-)-苄氧甲基环氧乙烷 Benzyl (R)-(-)-Glycidyl Ether,>;98.0%(GC)(14618-80-5)
  • 上游原料:乙酸乙酯 --> N,N-二甲基甲酰胺 --> 石油醚 --> 氢化钠 --> 溴化苄 --> (S)-缩水甘油
  • (R)-苄氧甲基环氧乙烷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 B2238 苄基(R)-(-)-缩水甘油醚 Benzyl (R)-(-)-Glycidyl Ether 5G 1760元 2011/04/16 B2238 苄基(R)-(-)-缩水甘油醚 Benzyl (R)-(-)-Glycidyl Ether 25G 4680元 2011/04/16 B2238 苄基(R)-(-)-缩水甘油醚 Benzyl (R)-(-)-Glycidyl Ether 1G 629元
  • (R)-苄氧甲基环氧乙烷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 B2238 苄基(R)-(-)-缩水甘油醚 Benzyl (R)-(-)-Glycidyl Ether 5G 2140元 2014/06/02 B2238 苄基(R)-(-)-缩水甘油醚 Benzyl (R)-(-)-Glycidyl Ether 25G 5670元 2014/06/02 B2238 苄基(R)-(-)-缩水甘油醚 Benzyl (R)-(-)-Glycidyl Ether 1G 762元
  • MOL 文件:14618-80-5.mol
  • Sigma Aldrich:14618-80-5(sigmaaldrich)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Catalysis and Inorganic Chemistry 催化剂和无机化学
  3. Iron - 铁催化剂
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Application Specific Reagents - Analytical Reagents
  4. Decomposition Reagents - Application Specific Reagents
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Arenes 芳烃
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Ethers - Oxygen Compounds
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Building Blocks 手性分子砌块
  4. Organic Building Blocks - Chiral Building Blocks
  5. Epoxides - Organic Building Blocks
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Building Blocks 手性分子砌块
  4. Organic Building Blocks - Chiral Building Blocks
  5. Epoxides - Organic Building Blocks
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Building Blocks 手性分子砌块
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Simple 3-Membered Ring Compounds 简单三元环化合物
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carboxylic Acids 羧酸

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