Amoxapine 阿莫沙平

CAS 14028-44-5 MFCD00069210

化学结构图

14028-44-5
SMILES: ClC1=CC2C(=NC3C=CC=CC=3OC=2C=C1)N1CCNCC1

化学属性

Mol. FormulaC17H16ClN3O
Mol. Weight313.79
TSCANo
Melting Point178.0 to 182.0 deg-C

别名和识别编码

Chemical NameAmoxapine
CAS Number14028-44-5
Synonym 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine 2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine 2-Chloro-11-(1-piperazinyl)dibenz[b.f][1,4]oxazepine Amoxan Amoxapine Asendin Asendis CL 67772 CL-67772 Defanyl Demolox Moxadil
MDL NumberMFCD00069210
PubChem Substance ID181085854
EC Number237-867-1
Merck Number576
Chemical Name Translation阿莫沙平
Wiswesser Line NotationT C676 BO INJ MG J- DT6M DNTJ
Beilstein Registry Number0832057
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分类

  • Pharmaceuticals
  • {SNA} A-AM, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Biogenic Amine Transport Inhibitors, Diversification Ready Pharma-Developed Compounds, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmission (Obesity), Neurotransmitters, Wyeth, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 肥胖研究, 蛋白质及衍生物
  • {SNA} A-AM, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Biogenic Amine Transport Inhibitors,

产品应用

  • Antidepressant.

相关文献及参考

  • Takahashi, R., et al.: J. Int. Med. Res., 7, 7 (1979),

安全信息

WGK Germany3
GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
RTECSHQ4025500
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes Xn
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 70 mg/kg/3W-I
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JCLPDE Journal of Clinical Psychiatry.  (Physicians Postgraduate Press,
   Inc., POB 240008, Memphis, TN 38124)  V.39-    1978-
   Volume(issue)/page/ye

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Cardiac - pulse rate increase, without fall in BP
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   250,1069,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 4286 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   SMJOAV Southern Medical Journal.  (Southern Medical Assoc., POB 2446,
   Birmi

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 385 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 5,1852,1971

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES

Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P308+P311
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P405 Store locked up. 上锁保管。
  • P301+P312+P330
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。

系列性分类


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