(S)-3-(3,4-Dihydroxyphenyl)-2-Hydrazinyl-2-Methylpropanoic Acid (S)-3-(3,4-二羟基苯基)-2-肼基-2-甲基丙酸

CAS 28860-95-9 MFCD00069231

化学结构图

28860-95-9
SMILES: CC(CC1=CC(O)=C(O)C=C1)(NN)C(O)=O

化学属性

Mol. FormulaC10H14N2O4
Mol. Weight226

别名和识别编码

Chemical Name(S)-3-(3,4-Dihydroxyphenyl)-2-Hydrazinyl-2-Methylpropanoic Acid
Synonym (S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid (S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid S-(-)-α-Hydrazino-3,4-dihydroxy-2-methylbenzenepropanoic acid (S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid S-(-)-α-Hydrazino-3,4-dihydroxy-2-methylbenzenepropanoic acid Benzenepropanoic acid, alpha-hydrazino-3,4-dihydroxy-alpha-methyl-, (S)- Carbidopa Hydrazino-alpha-methyldopa L-alpha-Methyldopahydrazine MK 486 N-Aminomethyldopa S-(-)-Carbidopa S-(-)-α-Hydrazino-3,4-dihydroxy-2-methylbenzenepropanoic acid alpha-Methyldopahydrazine
MDL NumberMFCD00069231
PubChem Substance ID24892402
CAS Number28860-95-9
EC Number249-271-9
Chemical Name Translation(S)-3-(3,4-二羟基苯基)-2-肼基-2-甲基丙酸
Wiswesser Line NotationZMX1&VQ1R CQ DQ
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分类

  • {SNA} A to C, Aromatic L-amino acid decarboxylase inhibitor, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, 生化试剂, 酶、抑制剂和底物
  • {SA} Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, L-Aromatic Amino Acid Decarboxylase,

相关文献及参考

  • 1. Gilbert, J.A., et al., Hydrogen peroxide degradation and selective carbidopa-induced cytotoxicity against human tumor lines Biochem. Pharmacol. 69 , 1159-1166, (2005) 摘要
  • Deleu, D., et al. Naunyn Schmiedebergs Arch. Pharmacol. 348 , 576, (1993) 摘要
  • Kaakkola, S., et al. J. Neurochem. 60 , 137, (1993) 摘要
  • Merck 14 ,1797

安全信息

WGK Germany3
RTECSMW5298000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 468 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 31,1127,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2804 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 31,1127,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 49,415,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2880 mg/kg
SEX/DURATION            : female 90 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   66,201,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2100 mg/kg
SEX/DURATION            : female 1-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   38,251,1976

系列性分类


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