(S)-(+)-Ibuprofen (S)-(+)-布洛芬

CAS 51146-56-6 MFCD00069289

化学结构图

51146-56-6
SMILES: CC(C)CC1=CC=C(C=C1)[C@H](C)C(O)=O

化学属性

Mol. FormulaC13H18O2
Mol. Weight206
Melting Point49-53
Density1.422
Boiling Point113

别名和识别编码

Chemical Name(S)-(+)-Ibuprofen
CAS Number51146-56-6
Alfabeta NameISOBUTYLPHENYLPROPANOICACID S24(())---
MDL NumberMFCD00069289
Synonym (S)-(+)-布洛芬 (S)-(+)-2-(4-异丁基苯基)丙酸 (S)-(+)-4-异丁基-α-甲基苯乙酸 (S)-(+)-2-(4-异丁基苯基)丙酸 (S)-(+)-4-异丁基-α-甲基苯乙酸 (?S)- (S)-(+)-2-(4-异丁基苯基)丙酸 (S)-(+)-4-异丁基-α-甲基苯乙酸 (S)-(+)-2-(4-异丁基苯基)丙酸 (S)-(+)-4-异丁基-α-甲基苯乙酸 S-(+)-IBU S-(+)-IBU
Beilstein Registry Number3590022
PubChem Substance ID87571895
Reaxys-RN3590020
EC Number250-023-7
Chemical Name Translation(S)-(+)-布洛芬
LabNetwork Molecule IDLN00177146
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分类

  • Inhibitors
  • {SNA} Asymmetric Synthesis, Carboxylic Acids, Chemical Synthesis, Chiral Building Blocks, Organic Building Blocks
  • {SNA} Asymmetric Synthesis, Bioactive Small Molecules, Carboxylic Acids, Cell Biology, Chemical Synthesis, Chiral Building Blocks, I, Organic Building Blocks
  • Chiral Reagents
  • Phar

产品应用

  • A nonsteroidal anti-inflammatory drug (NSAID); activity resides primarily in the (S)-isomer.

相关文献及参考

  • Busson, M., et al.: J. Int. Med Res., 14, 53 (1986),
  • Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993),
  • Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998),
  • Mehvar, et al., Liquid chromatography assay of ibuprofen enantiomers in plasma. Clin. Chem. 34 , 493-496, (1988) 摘要
  • Mehvar, et al., Pharmacokinetic analysis of the enantiomeric inversion of chiral nonsteroidal antiinflammatory drugs. Pharmacol. Res. 5 , 76-79, (1988) 摘要
  • Jeffrey, et al., The site of inversion of R(−)-ibuprofen: Studies using rat in situ isolated perfused intestine/liver preparations. J. Pharm. Pharmacol. 43 , 715-720, (1991) 摘要

安全信息

Warnings IRRITANT
WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Signal word Warning
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P312
  • P302+P350
  • P305+P351+P338+P337+P313
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
GHS Symbol
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿

系列性分类

  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Building Blocks 手性分子砌块
  4. Organic Building Blocks - Chiral Building Blocks
  5. Carboxylic Acids - Organic Building Blocks
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Building Blocks 手性分子砌块
  4. Organic Building Blocks - Chiral Building Blocks
  5. Carboxylic Acids - Organic Building Blocks
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Lipids in Cell Signaling - Cell Signaling and Neuroscience
  5. Arachidonic Acid Cascade - Lipids in Cell Signaling
  6. Enzyme Inhibitors - Arachidonic Acid Cascade
  7. Cyclooxygenase - Enzyme Inhibitors
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Application Index - Enzymes, Inhibitors, and Substrates
  5. Cell Signaling Enzymes - Application Index
  6. Cyclooxygenase (COX) Enzymes - Cell Signaling Enzymes
  7. Cyclooxygenase Inhibitors - Cyclooxygenase (COX) Enzymes
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carboxylic Acid Salts 羧酸盐
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Cell Signaling Enzymes
  5. Cyclooxygenase (COX) Enzymes
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Lipids in Cell Signaling
  5. Arachidonic Acid Cascade
  6. Arachidonic Acid
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Cyclin Dependent Kinases
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Lipids
  4. Lipids in Cell Signaling
  5. Arachidonic Acid Cascade
  6. Arachidonic Acid

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