Prochlorperazine Dimaleate 2-氯-10-(3-(4-甲基哌嗪-1-基)丙基)-10H-吩噻嗪二马来酸盐
CAS 84-02-6 MFCD00069330
化学结构图
SMILES: CN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1.O=C(O)/C=C\C(=O)O.O=C(O)/C=C\C(=O)O
化学属性
| Mol. Formula | C28H32ClN3O8S |
|---|---|
| Mol. Weight | 606 |
别名和识别编码
| Chemical Name | Prochlorperazine Dimaleate |
|---|---|
| CAS Number | 84-02-6 |
| Synonym | 10H-Phenothiazine, 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-, 2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine, dimaleate 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine dimaleate Buccastem Compazine Emetiral Meterazin Maleate Meterazin maleate Nibromin A Pasotomin Prochloroperazine Dimaleate Prochlorperazine Hydrogen Maleate Prochlorperazine Maleate Prochlorperazine dimaleate salt Stemetil Stemetil Dimaleate Vertigon |
| MDL Number | MFCD00069330 |
| PubChem Substance ID | 354335064 |
| EC Number | 201-511-3 |
| Chemical Name Translation | 2-氯-10-(3-(4-甲基哌嗪-1-基)丙基)-10H-吩噻嗪二马来酸盐 |
| Wiswesser Line Notation | T C666 BN ISJ EG B3- AT6N DNTJ D1 &OV1U1VO |
| Reaxys-RN | 3861788 |
| Merck Number | 7761 |
| LabNetwork Molecule ID | LN01343856 |
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分类
- {SNA} Analytical S
- Pharmaceuticals
- {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Signaling and Neuroscience, Dopaminargics - Antagonists,
- {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Dopaminargics - Antagonists, Dopaminergics, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, GlaxoSmithKline, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, PI-PZ, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 蛋白质及衍生物
产品应用
- Antiemetic.
相关文献及参考
- Taylor, W.B., et al.: Br. J. Clin. Pharmacol., 23, 137 (1987),
安全信息
GHS Symbol
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P312+P330
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H302 Harmful if swallowed 吞食有害
- H312 Harmful in contact with skin 皮肤接触有害
- H332 Harmful if inhaled 吸入有害
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 320 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,40,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 191 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PSYPAG Psychopharmacologia (Berlin). (Berlin, Ger.) V.1-46, 1959-76. For publisher information, see PSCHDL. Volume(issue)/page/year: 12,142,1968
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - woman DOSE/DURATION : 600 ug/kg/18H-I TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - muscle contraction or spasticity REFERENCE : SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1- 1908- Volume(issue)/page/year: 84,407,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 750 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 123,78,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE
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