Hydrocortisone 21-hemisuccinate sodium salt -

CAS 125-04-2 MFCD00069472

化学结构图

125-04-2
SMILES: CC12CCC(=O)C=C1CCC1C2C(O)CC2(C)C1CCC2(O)C(=O)COC(=O)CCC(=O)[O-].[Na+]

化学属性

Mol. FormulaC25 H33 O8 . Na
Mol. Weight484.51
Appearance 氢化可的松琥珀酸钠(125-04-2)为白色或近白色结晶性粉末；无臭、无味，有吸湿性。易溶于水和乙醇，不溶于三氯甲烷，水溶液不稳定。 powder
SolubilityH2O: 50 mg/mL
Melting Point>160°C
Boiling Point
Flash Point-

别名和识别编码

Chemical NameHydrocortisone 21-hemisuccinate sodium salt
CAS Number125-04-2
Synonym ######## 11BETA,17ALPHA,21-TRIHYDROXY-4-PREGNENE-3,20-DIONE 21-HEMISUCCINATE SODIUM SAL 11BETA,17ALPHA,21-TRIHYDROXY-4-PREGNENE-3,20-DIONE 21-HEMISUCCINATE SODIUM-POTASSIUM SALT 11b,17a,21-Trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate sodium salt 11b,17a,21-trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate sodium salt 11β,17α,21-Trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate 钠盐 氢化可的松 21-半琥珀酸酯 钠盐 4-PREGNEN-11-BETA, 17,21-TRIOL-3,20-DIONE 21-HEMISUCCINATE SODIUM SALT 4-PREGNEN-11BETA,17ALPHA,21-TRIOL-3,20-DIONE 21-HEMISUCCINATE SODIUM A-Hydrocort Buccalsone CORTISOL 21-HEMISUCCINATE CORTISOL 21-HEMISUCCINATE SODIUM SALT CORTISOL 21-HEMISUCCINATE SODIUM-POTASSIUM SALT Corlan Cort Cortisol 21-sodium succinate Cortisol hemisuccinate sodium salt
MDL Number-
PubChem Substance ID23694214
EC Number204-725-5
Chemical Name Translation-
Wiswesser Line NotationL E5 B666 OV MUTJ A1 CQ E1 FVYQOV2VO FQ &-NA- &43/36
InChIInChI=1S/C25H34O8.Na/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30);/q;+1/p-1/t16-,17-,18-,22+,23-,24-,25-;/m0./s1
Canonical SMILES-
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分类

  • {SNA} Bioactive Small Molecules, Cell Culture, Cell Signaling and Neuroscience, Corticosteroid, Cytokines, Growth Factors and Hormones, H, Hormones, Reagents and Supplements, Steroid Hormones, 细胞生物学
  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Corticosteroid, Cytokines, Growth Factors and Hormones, H, Hormones, Reagents and Supplements, Steroid Hormones
  • Steroids
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {SNA} B
  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Corticosteroid, Cytokines, Growth Factors and Hormones,

产品应用

  • ########

相关文献及参考

  • Akatsuka, K. et al.: Mei. Yak. Daig. Ken. Kiyo, 5, 11 (1975); Tank, N.A. et al.: Res. J. Pharmac. Biol. Chem. Sci., 2, 817 (2011);

安全信息

WGK Germany3
RTECSGM9015000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition +4°C -20°C 4 4°C 4℃ 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 2857 ug/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - bronchiolar constriction
   Gastrointestinal - nausea or vomiting
   Blood - oxidant related (GPD deficient) anemia
REFERENCE :
   MJAUAJ Medical Journal of Australia.  (Australasian Medical Pub. Co. Ltd.,
   71-79 Arundel St., Glebe, N.S.W., Australia)  V.1-    1914-
   Volume(issue)/page/year: 154,210,1991

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1320 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,625,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1050 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,625,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Ocular
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 120 mg/kg
SEX/DURATION            : f

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1200 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - physical
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 4,2957,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1600 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 33,68C,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1800 mg/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 4,2969,1970

其他信息

  • 用途一:用作医药中间体
  • Sigma Aldrich:125-04-2(sigmaaldrich)
  • MOL 文件:125-04-2.mol

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. H - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Corticosteroid - Steroid Hormones

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