Medroxyprogesterone 甲羟孕酮

CAS 520-85-4 MFCD00069474

化学结构图

520-85-4
SMILES: CC(=O)C1(O)CCC2C3CC(C)C4=CC(=O)CCC4(C)C3CCC21C

化学属性

Mol. FormulaC22H32O3
Mol. Weight344.50
Melting Point215.0 to 220.0 deg-C

别名和识别编码

Chemical NameMedroxyprogesterone
Synonym (6 alpha)-17-Hydroxy-6-methylpregn-4-ene-3,20-dione 17 alpha Hydroxy 6 alpha Methylprogesterone 17 alpha-Hydroxy-6 alpha-Methylprogesterone 17-Hydroxy-6-methyl-4-pregnene-3,20-dione 17-hydroxy-6-methyl-20-dion(6-alpha)-pregn-4-ene- 17-hydroxy-6-methyl-20-dion(6alpha)-pren-4-ene- 17-hydroxy-6alpha-methyl-pregn-4-ene-3,20-dione 17ALPHA-HYDROXY-6ALPHA-METHYL-4-PREGNENE-3,20-DIONE 17α-Hydroxy-6α-methyl-4-pregnene-3,20-dione 17α-羟基-6α-甲基-4-孕烯-3,20-二酮 17α-羟基-6α-甲基孕酮 6α-甲基-5-孕甾烯-17α-醇-3,20-二酮 6-二氢甲地孕酮 4-PREGNEN-6-ALPHA-METHYL-17-OL-3,20-DIONE 6-ALPHA-METHYL-17-HYDROPROGESTERONE 6-DIHYDROMEGESTROL 6-alpha-Methyl-17-alpha-hydroxyprogesterone 6ALPHA-METHYL-17ALPHA-H 6ALPHA-METHYL-5-PREGNEN-17ALPHA-OL-3,20-DIONE Adgyn Medro Medroxyprogesteron {PubChem}
MDL NumberMFCD00069474
PubChem Substance ID10631
Beilstein Registry Number2510965
CAS Number520-85-4
EC Number208-298-6
Chemical Name Translation甲羟孕酮
Merck Number5793
Wiswesser Line NotationL E5 B666 OV MUTJ A1 E1 FV1 FQ K1
Reaxys-RN2510965
LabNetwork Molecule IDLN01287488
InChIInChI=1S/C22H32O3/c1-13-11-16-17(20(3)8-5-15(24)12-19(13)20)6-9-21(4)18(16)7-10-22(21,25)14(2)23/h12-13,16-18,25H,5-11H2,1-4H3/t13-,16+,17-,18-,20+,21-,22-/m0/s1
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分类

  • {SNA} APIs & Metabolites, APIs (Active Pharmaceutical Ingredients) & Metabolites, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Application Areas and Market Segments, Bioactive Small Molecules, Cell Biology, Chromatography, Clinical Standards, Hormones, M, MEA - MES, Medroxyprogesteron, Neats and Solutions, Pharma, Pharmaceutical Standards
  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, M, Progesterone, Steroid H

相关文献及参考

  • Merck 14 ,5793

安全信息

RTECSTU5300000
GHS Symbol
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P203
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P308+P313
  • P318
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
Hazard Codes Xn
WGK Germany3
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges dust mask type N95 (US), Eyeshields, Gloves
Signal word
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘;
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
Risk Statements
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
  • R48 Danger of serious damage to health by prolonged exposure 长期接触有严重损害健康的危险
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 6 mg/kg/13W-I
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - sensory change involving peripheral nerve
   Behavioral - hallucinations, distorted perceptions
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   MJAUAJ Medical Journal of Australia.  (Australasian Medical Pub. Co. Ltd.,
   71-79 Arundel St., Glebe, N.S.W., Australia)  V.1-    1914-
   Volume(issue)/page/year: 163,51,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 625 mg/kg
SEX/DURATION            : female 10 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 12,445,1966

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 5 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press,
   1965  Volume(issue)/page/year: -,57,1965

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 20 mg/kg
SEX/DURATION            : female 17-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   ECJPAE Endocrinologia Japonica.  (Japan Pub. Trading Co., Ltd., POB 5030,
   Tokyo International, Tokyo, Japan)  V.1-    1954-  Volume(issue)/page/year:
   24,77,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1120 mg/kg
SEX/DURATION            : male 16 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   acce

其他信息

  • MOL 文件:520-85-4.mol
  • Sigma Aldrich:520-85-4(sigmaaldrich)

系列性分类


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