Buthionine sulfoximine DL-丁硫氨酸-(S,R)-亚砜亚胺

CAS 5072-26-4 MFCD00070309

化学结构图

5072-26-4
SMILES: CCCCS(=N)(=O)CCC(N)C(=O)O

化学属性

Mol. FormulaC8 H18 N2 O3 S
Mol. Weight222.31
Melting Point>200C (dec.)
SolubilityH2O: 50 mg/mL, clear, colorless
Boiling Point
Flash Point-

别名和识别编码

Chemical Name2-Amino-4-(Butylsulfonimidoyl)Butanoic Acid
CAS Number5072-26-4
Synonym 2-Amino-4-(S-butylsulfonimidoyl)butanoic acid 2-Amino-4-(S-butylsulfonimidoyl)butyric acid 2-amino-4-(s-butylsulfonimidoyl)-butanoicaci 2-amino-4-(s-butylsulfonimidoyl)butanoicacid Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-. Buthionine Sulfoximine Buthionine sulfoxamine Buthionine sulphoximine Butionine sulfoximine D,L-Buthionine-(S,R)-sulfoximine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL Number-
PubChem Substance ID21157
Beilstein Registry Number2367136
EC Number246-685-1
Chemical Name TranslationDL-丁硫氨酸-(S,R)-亚砜亚胺
Merck Number13,1520
LabNetwork Molecule IDLN01277805
InChIInChI=1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)
Canonical SMILES-
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分类

  • {SNA} B, Bioactive Small Molecules, Biochemicals and Reagents, Cell Signaling and Neuroscience, D to K, Drug and Xenobiotic Metabolism, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Fusarinine -C Ornithinesterase, Multi-Drug Resistance and Drug Metabolism, Substrates, Inducers, Inhibitors, 细胞生物学
  • {S
  • {SNA} Enzyme Inhibitors, Enzyme Inhibitors by Type, Organic Covalent Modifiers, 生化试剂, 酶、抑制剂和底物
  • {SNA} B, Bioactive Small Molecule Alphabetical Index, D to K, Drug and Xenobiotic Metabolism, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,

产品应用

  • A potent and specific inhibitor of alpha-glutamyl cysteine synthetase.

相关文献及参考

  • Griffith, O.W., et al.: J. Biol. Chem., 254, 16, 7558 (1979),
  • Griffith, O.W., et al.: Methods Enzymol., 77, 59 (1981),
  • 1. Hirai, Y., et al., Effect of 2-methoxyestradiol, buthionine sulfoximine and hydrogen peroxide on the viability of renal carcinoma cell lines (ACHN and ACVB) Biol. Pharm. Bull. 29 , 1064-1067, (2006) 摘要
  • 2. O.W. Griffith Meth. Enzymol. 77 , 59, (1981) 摘要
  • 3. M.A. Baker et al. Anal. Biochem. 190 , 360, (1990) 摘要
  • Merck 14 ,1526

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P317
  • P337+P317
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi
RTECSEK7713435
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition -20 -20°C -20℃ 2-8°C 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 gm/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
   Reproductive - Maternal Effects - other effects
REFERENCE :
   REPTED Reproductive Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1987-  Volume(issue)/page/year:
   6,133,1992

其他信息

  • MOL 文件:5072-26-4.mol
  • F:10
  • 下游产品:水星
  • Sigma Aldrich:5072-26-4(sigmaaldrich)
  • 丁基硫价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 309470050 丁基硫 DL-Buthionine (S,R)-sulfoximine 99% 5 GR 6169元 2010/06/21 309475000 丁基硫 DL-Buthionine (S,R)-sulfoximine 99% 500 MG 1041元
  • Acros Organics:DL-丁硫氨酸(S,R)-亚砜亚胺 DL-Buthionine (S,R)-sulfoximine, 99%(5072-26-4)

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. B - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. D to K - Enzyme Inhibitors by Enzyme
  7. Fusarinine -C Ornithinesterase - D to K
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Type - Enzyme Inhibitors
  6. Organic Covalent Modifiers - Enzyme Inhibitors by Type
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Multi-Drug Resistance and Drug Metabolism - Cell Signaling and Neuroscience
  5. Drug and Xenobiotic Metabolism - Multi-Drug Resistance and Drug Metabolism
  6. Substrates, Inducers, Inhibitors - Drug and Xenobiotic Metabolism
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Sulfur Compounds 硫化合物
  5. Sulfonimides/Sulfinimides - Sulfur Compounds
  1. Functional Group 官能团索引
  2. sulfoxide
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Multi-Drug Resistance and Drug Metabolism
  5. Drug and Xenobiotic Metabolism
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Factor Xa

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